Assuntos
Água Doce/química , Testes de Mutagenicidade/métodos , Mutagênicos/toxicidade , Salmonella typhimurium/efeitos dos fármacos , Água do Mar/química , Poluentes Químicos da Água/toxicidade , Relação Dose-Resposta a Droga , Monitoramento Ambiental/métodos , Indóis , Resíduos Industriais/análise , Japão , Mutagênicos/análise , Compostos Organometálicos , Salmonella typhimurium/genética , Poluentes Químicos da Água/análiseRESUMO
An extracorporeal bypass was performed in mongrel dogs for 2 hours with or without hypertonic mannitol infusions. In animals given mannitol, the plasma osmolality was elevated maximally to 344 +/- 7.1 mOsm/L and the urine volume was maintained well during bypass. A hypertonic mannitol solution was effective in maintaining the CPAH during and after bypass, but was not effective in minimizing the reduction in Ccr. When the mean arterial pressure during bypass was kept at 60 mmHg, the carbon filling rates in glomeruli showed the favorable effects of mannitol upon renal function, but no effects were observed at a mean arterial pressure of 80 mmHg. In 11 patients who had undergone a bypass lasting more than 2 hrs with mannitol infusions, the plasma osmolality reflected the serum mannitol level and reached 320 +/- 11.0 mOsm/L at 150 min of bypass. The mean urine volume was 5.0 +/- 3.3 ml/min/M2 during the bypass, which was about 7 times as great as before the bypass. The Ccr increased during the first 30 min of the bypass, but it fell to about one half of the initial value after 90 min of the bypass. It was concluded that a hypertonic mannitol solution is effective in maintaining the RPF and urine volume during and after the bypass and that it also preserved the glomerular perfusion even at a low arterial pressure.
Assuntos
Procedimentos Cirúrgicos Cardíacos , Rim/fisiopatologia , Manitol/farmacologia , Injúria Renal Aguda/prevenção & controle , Adolescente , Adulto , Animais , Criança , Pré-Escolar , Cães , Circulação Extracorpórea , Feminino , Cardiopatias/fisiopatologia , Cardiopatias/cirurgia , Hemólise/efeitos dos fármacos , Humanos , Soluções Hipertônicas , Masculino , Pessoa de Meia-Idade , Concentração OsmolarAssuntos
Ruptura Aórtica/cirurgia , Idoso , Aorta Torácica/cirurgia , Prótese Vascular , Humanos , Pulmão , MasculinoAssuntos
Insuficiência da Valva Aórtica/cirurgia , Endocardite Bacteriana Subaguda/complicações , Próteses Valvulares Cardíacas , Insuficiência da Valva Mitral/cirurgia , Adulto , Valva Aórtica/cirurgia , Insuficiência da Valva Aórtica/etiologia , Endocardite Bacteriana Subaguda/cirurgia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Valva Mitral/cirurgia , Insuficiência da Valva Mitral/etiologiaRESUMO
Effects of pulsatile venous flow upon the microcirculation were investigated in conditions with different venous pressures by using regional perfusion in dog's hind legs. In animals with venous pressure of -18 cmH2O (Collapsed stage), venous pulsation brought about a significant increase in mean oxygen consumption ratio and suppressed a rise of mean resistance ratio significantly. In animals with venous pressure of +2 cmH2O (normal venous pressure stage), the venous pulsation was effective in a rise of mean oxygen consumption ratio but was not effective in suppression of mean resistance ratio. In animals with venous pressure of +10 cmH2O (congestive stage), no effect of venous pulsation was recognized. We suppose that the intermittent elevation of venous pressure by venous pulsation is effective for opening some capillaries in animals with venous pressure below +2 cmH2O.
Assuntos
Circulação Extracorpórea , Veias/fisiologia , Animais , Cães , Circulação Extracorpórea/métodos , Técnicas In Vitro , Microcirculação , Consumo de Oxigênio , Pulso Arterial , Resistência Vascular , Pressão VenosaAssuntos
Volume Cardíaco , Contração Miocárdica , Animais , Doença Crônica , Diástole , Cães , Cardiopatias/fisiopatologiaAssuntos
Ponte Cardiopulmonar , Rim/fisiologia , Manitol/farmacologia , Animais , Cães , Hematócrito , Soluções Hipertônicas , Rim/efeitos dos fármacos , PerfusãoAssuntos
Circulação Pulmonar , Animais , Dióxido de Carbono/sangue , Débito Cardíaco , Cães , Máquina Coração-Pulmão , Oxigênio/sangueRESUMO
A follow-up study on pacemaker function in 15 patients with implanted cardiac pacemaker has been performed by telephone transmission. The transmitting set consisting of electrocardiograph, pacemaker pulse modulator and acoustic coupler was manipulated by the patients themselves. ECG, pacemaker pulse, and pulse rate were simultaneously transmitted through 1 channel to the receiver in our clinic. Of 56 patients with pacemaker, 15 patients were surveyed by telephone transmission. In these patients battery exhaustion was detected in 3, competition in 2, and lead fracture in 1. The fact that surveillance and follow-up of the patients with implanted cardiac pacemaker could be carried out by telephone transmission as well as by clinic visitation tells us that the telephone transmission is a useful method and plays an important role in a pacemaker clinic. Moreover our study established its further usefulness in the patient's preference due to difficulties in travelling to the pacemaker clinic and in reducing patient's anxiety.
Assuntos
Monitorização Fisiológica/métodos , Marca-Passo Artificial , Telefone , Adolescente , Adulto , Arritmias Cardíacas/terapia , Criança , Pré-Escolar , Fontes de Energia Elétrica , Eletrocardiografia , Seguimentos , Bloqueio Cardíaco/terapia , Humanos , Pessoa de Meia-Idade , Pulso ArterialRESUMO
61 patient underwent operative repair of acquired tricuspid insufficiency (T.I.) during correction of multiple valvular disease. 45% presented a relative T.I. through annular dilatation, while organic lesions of the tricuspid valve were found in 56% of the patients. A tricuspid valvular replacement was carried out in 17, and a tricuspid annuloplasty in 44 patients. We believe that during surgical management of multiple valvular lesions, all tricuspid insufficiencies of even when only of a slight to moderate degree - should be corrected aggressively. Tricuspid valvular replacement should be avoided if possible and a tricuspid annuloplasty should be performed.