RESUMO
The role of age, gender and smoking on both the genotoxic effects of Helicobacter pylori and the efficacy of eradication therapy in a group of patients with gastritis was investigated. Gastritis was confirmed by endoscopy and biopsy, and the presence of H. pylori by urease testing. Pre- and post-treatment peripheral blood lymphocyte cultures were prepared from 17 patients and 25 metaphases per patients were analysed for sister chromatid exchange (SCE), a well-established technique for the evaluation of human exposure to toxic agents. Treatment with omeprazole, clarithromycin and amoxycillin triple therapy eradicated H. pylori in 94% of patients and significantly reduced the SCE frequency. Pre-treatment SCE frequency was found to be positively correlated with age. Female smokers tended to have higher post-treatment SCE frequencies than male smokers, and pre- and post-treatment SCE frequencies were higher in older males than in older females. Eradication therapy decreased the genotoxicity of H. pylori, but age in males and smoking in females may decrease treatment efficacy.
Assuntos
Infecções por Helicobacter/complicações , Fumar/efeitos adversos , Neoplasias Gástricas/etiologia , Adolescente , Adulto , Fatores Etários , Amoxicilina/administração & dosagem , Amoxicilina/uso terapêutico , Claritromicina/administração & dosagem , Claritromicina/uso terapêutico , Quimioterapia Combinada , Feminino , Infecções por Helicobacter/tratamento farmacológico , Humanos , Masculino , Pessoa de Meia-Idade , Omeprazol/administração & dosagem , Omeprazol/uso terapêutico , Fatores de Risco , Fatores Sexuais , Troca de Cromátide Irmã/efeitos dos fármacos , Neoplasias Gástricas/microbiologiaRESUMO
Management of poisoned patient requires accurate knowledge of intoxication. Uludao Poison Information Center (UPIC), founded in January 1996, provides acquired information 24 hours a day 7 days a week for physicians and consultants. We received 2270 phone calls since January 1996 till October 1998 and evaluated the cases statistically regarding "distribution of age and gender", "calling time after poison exposure", "source of poisoning", "reason for intoxication" and "source of calls" to reveal the distinguishing features of intoxication. Intoxication was mostly seen between 14-25 years of age (964 cases, 42.46%) and in females (1367 cases, 60.22%). Drugs (1400 cases, 61.67%) were the main source and suicide attempts (930 cases, 40.9%) were the main reason of poisoning. Most of the calls were from healthcare professionals (1347, 59.33%).