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1.
Sci Rep ; 14(1): 15910, 2024 Jul 10.
Artigo em Inglês | MEDLINE | ID: mdl-38987306

RESUMO

Mass vaccinations are crucial public health interventions for curbing infectious diseases. Canine rabies control relies on mass dog vaccination campaigns (MDVCs) that are held annually across the globe. Dog owners must bring their pets to fixed vaccination sites, but sometimes target coverage is not achieved due to low participation. Travel distance to vaccination sites is an important barrier to participation. We aimed to increase MDVC participation in silico by optimally placing fixed-point vaccination locations. We quantified participation probability based on walking distance to the nearest vaccination site using regression models fit to participation data collected over 4 years. We used computational recursive interchange techniques to optimally place fixed-point vaccination sites and compared predicted participation with these optimally placed vaccination sites to actual locations used in previous campaigns. Algorithms that minimized average walking distance or maximized expected participation provided the best solutions. Optimal vaccination placement is expected to increase participation by 7% and improve spatial evenness of coverage, resulting in fewer under-vaccinated pockets. However, unevenness in workload across sites remained. Our data-driven algorithm optimally places limited resources to increase overall vaccination participation and equity. Field evaluations are essential to assess effectiveness and evaluate potentially longer waiting queues resulting from increased participation.


Assuntos
Doenças do Cão , Raiva , Zoonoses , Animais , Raiva/prevenção & controle , Raiva/veterinária , Raiva/epidemiologia , Zoonoses/prevenção & controle , Zoonoses/epidemiologia , Humanos , Cães , Doenças do Cão/prevenção & controle , Doenças do Cão/epidemiologia , Vacina Antirrábica/administração & dosagem , Vacina Antirrábica/imunologia , Vacinação , Vacinação em Massa/métodos , Vacinação em Massa/estatística & dados numéricos , Algoritmos , Epidemias/prevenção & controle
2.
Am J Trop Med Hyg ; 103(3): 1247-1257, 2020 09.
Artigo em Inglês | MEDLINE | ID: mdl-32662391

RESUMO

Since its reintroduction in 2015, rabies has been established as an enzootic disease among the dog population of Arequipa, Peru. Given the unknown rate of dog bites, the risk of human rabies transmission is concerning. Our objective was to estimate the rate of dog bites in the city and to identify factors associated with seeking health care in a medical facility for wound care and rabies prevention follow-up. To this end, we conducted a door-to-door survey with 4,370 adults in 21 urban and 21 peri-urban communities. We then analyzed associations between seeking health care following dog bites and various socioeconomic factors, stratifying by urban and peri-urban localities. We found a high annual rate of dog bites in peri-urban communities (12.4%), which was 2.6 times higher than that in urban areas (4.8%). Among those who were bitten, the percentage of people who sought medical treatment was almost twice as high in urban areas (39.1%) as in peri-urban areas (21.4%).


Assuntos
Mordeduras e Picadas/epidemiologia , Doenças do Cão/epidemiologia , Aceitação pelo Paciente de Cuidados de Saúde/estatística & dados numéricos , Vacina Antirrábica/uso terapêutico , Raiva/epidemiologia , Fatores Socioeconômicos , Adulto , Animais , Mordeduras e Picadas/virologia , Demografia , Doenças do Cão/virologia , Cães , Monitoramento Epidemiológico , Feminino , Instalações de Saúde , Humanos , Masculino , Pessoa de Meia-Idade , Peru/epidemiologia , Profilaxia Pós-Exposição/estatística & dados numéricos , Raiva/virologia , Risco , Inquéritos e Questionários , População Urbana , Zoonoses
3.
PLoS Negl Trop Dis ; 13(8): e0007600, 2019 08.
Artigo em Inglês | MEDLINE | ID: mdl-31369560

RESUMO

To control and prevent rabies in Latin America, mass dog vaccination campaigns (MDVC) are implemented mainly through fixed-location vaccination points: owners have to bring their dogs to the vaccination points where they receive the vaccination free of charge. Dog rabies is still endemic in some Latin-American countries and high overall dog vaccination coverage and even distribution of vaccinated dogs are desired attributes of MDVC to halt rabies virus transmission. In Arequipa, Peru, we conducted a door-to-door post-campaign survey on >6,000 houses to assess the placement of vaccination points on these two attributes. We found that the odds of participating in the campaign decreased by 16% for every 100 m from the owner's house to the nearest vaccination point (p = 0.041) after controlling for potential covariates. We found social determinants associated with participating in the MDVC: for each child under 5 in the household, the odds of participating in the MDVC decreased by 13% (p = 0.032), and for each decade less lived in the area, the odds of participating in the MDVC decreased by 8% (p<0.001), after controlling for distance and other covariates. We also found significant spatial clustering of unvaccinated dogs over 500 m from the vaccination points, which created pockets of unvaccinated dogs that may sustain rabies virus transmission. Understanding the barriers to dog owners' participation in community-based dog-vaccination programs will be crucial to implementing effective zoonotic disease preventive activities. Spatial and social elements of urbanization play an important role in coverage of MDVC and should be considered during their planning and evaluation.


Assuntos
Doenças do Cão/prevenção & controle , Programas de Imunização , Vacinação em Massa/veterinária , Vacina Antirrábica , Raiva/prevenção & controle , Cobertura Vacinal , Animais , Pré-Escolar , Doenças do Cão/transmissão , Cães , Características da Família , Humanos , Análise Multivariada , Razão de Chances , Peru , Raiva/transmissão , Vírus da Raiva/imunologia , Análise de Regressão , Inquéritos e Questionários
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