RESUMO
BACKGROUND: Venous ulcers are common complications of chronic venous insufficiency that result in severe physical and mental suffering to patients. The oral administration of diosmin/hesperidin has been used as adjuvant therapy in the treatment of chronic venous insufficiency. The purpose of this study was to evaluate and compare the effect of pycnogenol and diosmin/hesperidin on the healing of venous ulcers. METHODS: This longitudinal, prospective, randomized clinical trial was conducted with 30 adult patients with venous ulcers from a vascular surgery outpatient clinic of a university hospital. The patients were randomly allocated to 2 groups: Group 1 (n = 15) was treated with pycnogenol (50 mg orally, 3 times daily) and Group 2 (n = 15) was treated with diosmin/hesperidin (450/50 mg orally, twice daily). They were assessed every 15 days for 90 days. During follow-up visits, photo-documentation was obtained and the ulcer area and circumference of the affected limb were measured. Friedman's test and Mann-Whitney test were used to compare ulcer areas and circumference of affected limbs between and within groups at different time points. The level of significance was set at 5% (P < 0.05) for all tests. RESULTS: Both the pycnogenol and diosmin/hesperidin treatments had a similar effect on the healing of venous ulcers and led to a significant decrease in the circumference of affected limbs (P < 0.0001). CONCLUSION: The results suggest that pycnogenol has an adjuvant effect on the healing of venous ulcers, similar to diosmin/hesperidin.
Assuntos
Diosmina/uso terapêutico , Flavonoides/uso terapêutico , Hesperidina/uso terapêutico , Úlcera Varicosa/tratamento farmacológico , Cicatrização/efeitos dos fármacos , Administração Oral , Idoso , Brasil , Diosmina/administração & dosagem , Diosmina/efeitos adversos , Esquema de Medicação , Combinação de Medicamentos , Feminino , Flavonoides/administração & dosagem , Flavonoides/efeitos adversos , Hesperidina/administração & dosagem , Hesperidina/efeitos adversos , Humanos , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Extratos Vegetais , Estudos Prospectivos , Fatores de Tempo , Resultado do Tratamento , Úlcera Varicosa/diagnósticoRESUMO
A presenta-se o caso de um paciente que desenvolveu câncer do testículo com metástase à distância em torno de cinco meses depois de ter sido internado, tratado e curado de síndrome de Fournier. Esse paciente evoluiu para o óbito sem qualquer oportunidade terapêutica, pela alta malignidade da evolução tumoral.