[The effect of immunosuppressive substances on the zinc content in cells]. / Vliianie immunosupressivnykh veshchestv na soderzhanie tsinka v kletkakh.

Decreases in zinc levels in the cells of various organs were observed in mice received cyclosporin A and sodium diethyldithiocarbamate. Glucocorticoid therapy induced a decrease of zinc levels in the granulocytes of human peripheral blood. The role of alterations in cell zinc metabolism in the mechanism of action of immunosuppressive agents is discussed in the paper.

[The effect of cyclosporin A on the islet cells of mice]. / Vliianie tsiklosporina A na insuliarnyi apparat myshei.

The action of immunosuppressive agent ciclosporin A on the insular apparatus was studied with an original method of cytochemical zinc detection in experiments on mice. The drug was found to lower zinc levels in pancreatic beta-cells. In ciclosporin A pretreatment the sensitivity of mice to zinc-binding diabetogenic agent enhanced.