RESUMO
Subacute sclerosing panencephalitis (SSPE) is a progressive, slow virus infection of the brain, caused by the measles virus, attacking children and young adults. We investigated 15 patients with SSPE by MRI, with 5 normal and 10 pathological results. In the early period, lesions were in the grey matter and subcortical white matter. They were asymmetrical and had a predilection for the posterior parts of the hemispheres. Later, high-signal changes in deep white matter and severe cerebral atrophy were observed. Parenchymal lesions significantly correlated with the duration of disease. A significant relationship between MRI findings and clinical stage was observed in the 1st year of the disease.
Assuntos
Imageamento por Ressonância Magnética , Panencefalite Esclerosante Subaguda/diagnóstico , Adolescente , Adulto , Encéfalo/patologia , Córtex Cerebral/patologia , Ventrículos Cerebrais/patologia , Criança , Diagnóstico Diferencial , Dominância Cerebral/fisiologia , Feminino , Seguimentos , Humanos , MasculinoRESUMO
Our aim was to test the reliability of interpreting MRI studies in neuro-Behçet's disease (NBD) and to determine the sensitivity and specificity of different MRI findings. We prospectively studied 50 patients: 24 had chronic NBD, 12 multiple sclerosis, 5 vasculitis other than Behçet's disease (BD) and 9 patients had BD without neurological involvement. MRI studies were performed according to a standard protocol with a 0.2 T imager. Two neuroradiologists, blinded to the diagnosis, age and sex of the subjects, reviewed the films independently, twice. Separate assessments were made for a set of items: dural sinus pathology, widening of ventricles and sulci, brain stem atrophy, lesions of the cerebral cortex, discrete lesions of deep white matter, basal ganglia, brain stem and cerebellum and the presence of smooth periventricular high-signal foci. Intraobserver agreement was substantial or better, and interobserver agreement moderate to substantial for most items. In these patients with chronic NBD we found low sensitivity on all assessed items. Dural sinus pathology or brain stem atrophy were highly specific, but parenchymal lesions in different sites had uniformly low specificity.
Assuntos
Síndrome de Behçet/diagnóstico , Encefalopatias/diagnóstico , Imageamento por Ressonância Magnética/estatística & dados numéricos , Encéfalo/patologia , Doenças Arteriais Cerebrais/diagnóstico , Diagnóstico Diferencial , Humanos , Esclerose Múltipla/diagnóstico , Exame Neurológico , Testes Neuropsicológicos , Variações Dependentes do Observador , Estudos Prospectivos , Pseudotumor Cerebral/diagnóstico , Reprodutibilidade dos Testes , Sensibilidade e Especificidade , Trombose dos Seios Intracranianos/diagnósticoRESUMO
The occurrence of an aneurysm, 2 x 2.5 cm in size, in the intrapetrosal portion of the internal carotid artery in a 24-year-old female patient, during the course of herpes zoster ophthalmicus, is described.