[The use of the antihypoxants olifen and amtizol for treating patients with chronic stage-IIB circulatory failure]. / Primenenie antigipoksantov olifena i amtizola dlia lecheniia bol'nykh a khronicheskoi nedostatochnost'iu krovoobrashcheniia IIB stadii.

To compare efficacy of conventional therapy, antihypoxants olifen and amthizol (groups 1, 2 and 3, respectively) 49 patients with congestive heart failure stage IIb according to the Vasilenko-Strazhesko classification were treated. In hospital the pre-hospital scheme of treatment was not changed except the following positions: group 1 patients received strophanthin instead of oral digoxin, group 2 and 3 patients received adjuvant olifen and amthizol, respectively. Stabilization of the condition occurred in 10 days, on the average, in each group. In the 1st group good results were obtained due to stroke volume increase, in the 2nd and 3d due to the ability of olifen and amthizol to prevent tissue hypoxia.

[Effectiveness of a series of pharmacological substances in liver ischemia]. / Issledovanie éffektivnosti riada farmakologicheskikh preparatov pri ishemii pecheni.

Antiischemic activity of alpha-tocopherol, prednisolone, T-407 and T-408 on functions of liver tissue was studied after 90 min contraction of hepatoduodenal ligament in 61 animals. All the preparations studied exhibited the antiischemic protection of liver tissue; the most effective drugs proved to be T-408 and prednisolone.

[The action of amtizol and gutimin on the respiratory metabolism of the neuron]. / Deistvie amtizola i gutimina na dykhatel'nyi metabolizm neirona.

The effects of antihypoxants gutimine and amtisole on oxygen consumption by the intact nerve cell of the invertebrate and the activity of NADN-DH and SDH-dependent ways of oxidation in the cell were studied. Under normoxia gutimine inhibited the nerve cell respiration and decreased the activity of NADN-DN and SDH-dependent ways of oxidation by 15% and 5% respectively. Amtisole activated the neuron respiration increasing the activity of NADN-DH-dependent way of oxidation. Both antihypoxants, despite the fact that they refer to the same class of compounds, have different mechanisms of action on the neuron metabolism. Gutimine appears to be a pharmacological agent, protector, amtisole as an initiator of the active adaptative reorganization of the intracellular metabolism.

[The structure and antihypoxic action of alpha-dicarbonyl compounds and their derivatives]. / Stroenie i antigipoksicheskaia aktivnostv al'fa-dikarbonil'nykh soedinenii i ikh proizvodnykh.

The protective action in hypoxic hypoxia of 29 synthetized alpha-dicarbonyl compounds were studied. In this series of substances the natihypoxic activity was found to be most marked in drugs whose redox potential amounted to 0.15--0.3 V and which displayed a high dehydrating activity. Such compounds include isatin, its 3-anyl, 3-thiosemicarbation of ethyl either, isatin-1 of acetic acid and acenaphthequinone. Substitution is position 1 and 3 of isatin can lead to the formation of active substances, whereas substitution in position 2 usually reduces the antihypoxic activity.