Plunging ranula as a complication of intraoral removal of a submandibular sialolith.

Mucous cysts in the submandibular region--so-called 'plunging' ranula--are relatively uncommon. We report a case of a plunging ranula that complicated excision of an intraductal sialolith of the submandibular gland.

Factors related to outcome in blunt intestinal injuries requiring operation.

Associated factors related to outcome following blunt intestinal trauma requiring operative therapy were retrospectively reviewed in all trauma patients admitted to one Level I trauma center. Over 4.5 years, 7598 trauma patients were evaluated, with 62 patients having sustained 92 blunt intestinal injuries requiring operative intervention. Mean age was 34.5 years; mean Injury Severity Score was 22. Mechanism of injury was motor vehicle accident in 50 (81%), with 80 per cent being drivers. Associated intra-abdominal injuries occurred in 46 (74%) patients. Extra-abdominal injuries occurred in 56 patients (90%). Thirty-one patients suffered 82 complications or 2.6 complications per patient (comp/pt). Mortality from operative blunt trauma was associated with admission blood pressure < or = 90 mm Hg (57 vs 13%; P < 0.05), age > or = 24 years (26 vs 0%; P < 0.05), and Injury Severity Score > or = 35 (70 vs 8%; P < 0.05). Morbidity was associated with age > or = 24 years (1.5 vs 0.7 comp/pt; P < 0.05) and delay in operative therapy > or = 24 hours (3.3 vs 1.1 comp/pt; P < 0.05). Overall mortality was 18 per cent.

[Comparison of echograms by a microscanner and histological findings of the common bile duct, in vitro study].

To confirm the relationship between the layer structure of the common bile duct by a microscanner (MS) and its histological features, we performed a study using the pinning method with needles and catgut. The locations of 67 needles inserted at random depths in 29 slices of the resected common bile duct from 18 patients were confirmed both by a MS and a microscope. The wall of the common bile duct was delineated as a two- (42 points) or three-layer structure (25 points); "low and high" or "high, low, and high echoic layers" from the mucosal side. A fibrotic layer (ss 1) was often (56/67 points, 16/18 patients) seen in the subserosa (ss) containing nerves and vessels larger than 100 mu in diameter. Among the 51 needle echoes demonstrated in the inner hypoechoic layer, 2 were located in the mucosa (m), 12 in the fm, 19 in the af, 17 in the ss 1, and 1 in the fatty layer of the ss (ss 2). Five of the 6 needles in the outer hyperechoic layer were in the ss 2, and 1 was in the pancreatic parenchyma (pa). Four of the 8 needles at the border between the inner hypoechoic layer and the outer hyperechoic layer histologically corresponded to fm, af, ss 1, and pa, respectively, and the other four corresponded to ss 2. From these results, we conclude that the inner hypoechoic layer contains not only m, fm, and af, but also ss 1. Therefore, this should be kept in mind for the preoperative assessment of the depth of bile duct carcinoma by MS.

[Ultrasonographic study of rectal carcinoid tumors].

To compare intraluminal ultrasonographic (ILUS) findings with histological findings of rectal carcinoid tumors, 35 patients with rectal carcinoid tumors were reviewed. The results were as follows: 1) The rectal wall was visualized as a seven- or nine-layer structure by means of ILUS in 81% of the patients. 2) The possibility that the thin hyperechoic third layer above the tumor on ILUS corresponds to the muscularis mucosae and fibrointerstitium above the tumor histologically. 3) In cases with relatively high internal echoes, the amount of fibrointerstitium exceeded that of tumor cells histologically. 4) In cases with nonuniform internal echo patterns, tumor cells were separated by thick fibrointerstitium forming nodular nests.

[Diagnosis of superficial-type early carcinoma of the gallbladder by endoscopic ultrasonography--comparison with ultrasonography].

The detectability of superficial-type carcinoma of the gallbladder by ultrasonography (US) and endoscopic ultrasonography (EUS) were investigated. Eight patients with such carcinoma of the gallbladder were reviewed. They had undergone both US and EUS previous to surgery. The tumor was detected in 3 patients by US, 2 patients with IIa + IIb-type carcinoma and 1 patient with IIa-type carcinoma. Those lesions were visualized as localized thickening of the gallbladder wall or as broad-based tumor. In 2 patients, lesions were not initially detected by US, but were shown by US after the examination by EUS. The tumor was detected by EUS also in 1 case of IIb + IIa-type carcinoma besides those 3 patients mentioned above. All four of these lesions were visualized as broad-based tumor by EUS. It was difficult to detect pure IIb-type or small IIa-type carcinoma even by EUS. In patients with concomitant acute cholecystitis or gallbladder stone, it was difficult to evaluate the abnormal findings of the gallbladder wall.

Expression of S-100 protein and glial fibrillary acidic protein in cultured submandibular gland epithelial cells and salivary gland tissues. Histogenetic implication for salivary gland tumors.

S-100 protein and glial fibrillary acidic protein (GFAP) were studied in human salivary gland tissues and human cultured submandibular gland epithelial cells. Immunohistochemically, ductal cells in normal salivary gland tissues were positive for S-100 protein and GFAP, but myoepithelial cells were uniformly negative. Immunocytochemically, cultured submandibular gland ductal cells were positive for S-100 protein and GFAP. By immunoblotting analysis of the cultured cell lysates, a 6.5-kd S-100 protein was detected. This band corresponded to S-100 protein purified from bovine brain. The cultured submandibular gland cells expressed 49- and 54-kd GFAP polypeptides. These results have important implications for the histogenesis of salivary gland tumors.

Bilateral popliteal artery injury from bumper crush injury.

Blunt trauma to the knee of sufficient force to result in knee dislocation or fracture is commonly associated with popliteal artery injury. The challenging problem of bilateral popliteal artery injury has been rarely reported. We describe a case of bilateral popliteal artery injury after bumper crush injury between two automobiles that illustrates a successful method of management. Expeditious revascularization with minimum ischemia time was obtained by using the posterior approach, rather than the conventional medial approach, allowing two surgical teams to work simultaneously.

Should critical care medicine be a formal part of the undergraduate curriculum?

Medical students were surveyed shortly after completing the third year of medical school. TIle survey was designed to identify those areas of critical care medicine students had been exposed to and expressed interest in learning more about. In addition, the surveys sought to discern the level of confidence students felt with respect to different critical illnesses and intensive care unit (lCU) therapeutic modalities.Finally, the students were asked their opinion regarding the possibility or need for critical care medicine as pan of their medical school curriculum.The three most common topics of interest among medical students who had recently ftnished their third year in medical school were shock, hemodynamic monitoring, and mechanical ventilation. Less than 30% of the students surveyed felt "better-than-average" confidence on anyone of a number of critical care topics and treatment modalities. Of the 80% of students (n = 70) who completed the survey, 91% (n = 64) felt that critical care medicine should be made a pan of the medical school curriculum,6% (n = 4) felt it should not, and 3% (n = 2) were undecided.TIle survey results and the finding that most of the relevant literature acknowledges the need for critical care medicine in medical school has led us to conclude that a national core clerkship or a didactic lecture series in critical care medicine should be carefully designed and implemented into the undergraduate curriculum.

Decreasing unplanned extubations in the surgical intensive care unit.

BACKGROUND: Unplanned extubations are common, but can be life-threatening. METHODS: We conducted a prospective evaluation of all intubated patients in our surgical intensive care unit to examine the effects of three parameters on the likelihood of accidental extubation. The parameters were the method of endotracheal tube fixation, the use of sedation/paralysis, and the use of hand restraints. During the baseline period, tubes were secured with cloth or velcro ties, sedation was used conservatively, and hand restraints were used routinely. A change in one study parameter was made prior to each period. Thus, in period II, tubes were secured using waterproof tape; in period III, tubes were secured with waterproof tape and sedation/paralysis was used liberally; and in period IV, tubes were secured with waterproof tape and limited use was made of hand restraints. RESULTS: Accidental extubations were significantly less frequent when tubes were secured with waterproof tape (P < 0.0001). No difference was seen when sedation was instituted liberally. Restricted use of hand restraints was associated with significantly increased accidental extubations (P < 0.001). CONCLUSIONS: Our data support the use of water resistant tape to secure endotracheal tubes and the routine use of hand restraints.

Ethanol added to resuscitation improves survival in an experimental model of hemorrhagic shock.

Ethyl alcohol induces systemic vasodilation, decreases platelet aggregation, and inhibits neutrophil activation in vivo. Alcohol may thus be of potential benefit in resuscitation from shock by improving microcirculation. The purpose of this study was to test the effects of ethanol (ETOH) in resuscitation from hemorrhagic shock. Blood pressure, tissue pO2, white blood cell (WBC) and platelet adhesiveness, and survival were measured for 60 male Sprague-Dawley rats in a blinded and randomized study. Anesthetized animals were phlebotomized to 60 per cent of their blood volume, and maintained in shock for 45 minutes. Resuscitation was by continuous infusion of Lactated Ringers (LR) at 2 x shed blood volume over 1 hour. The experimental group received LR and ETOH (1.25 mL/kg). Control rats received LR and placebo. Mean arterial pressure was not significantly different, nor was WBC adhesiveness index different. However, postresuscitation platelet adhesiveness index was significantly higher in control rats than in ETOH rats. Postresuscitation total platelet arterial-venous difference was also greater in controls than in ETOH rats. Average tissue pO2 for ETOH rats (47 +/- 8.2 mm Hg) was significantly higher than controls (39.0 +/- 9.8 mm Hg) during resuscitation (P = 0.0001). Survival for ETOH rats (70%) was significantly higher than controls (20%) (P = 0.003). Our data suggests that ETOH added to resuscitation from shock improves survival by inhibiting platelet activation and increasing tissue perfusion.

The effect of Polyethylene Glycol-Superoxide Dismutase on gastric mucosa and survival in shock with tissue injury.

Oxygen-derived free radicals may play an important role in the pathogenesis of organ injury and death following hemorrhagic shock. This study was designed to test the effects of Polyethylene Glycol-Superoxide Dismutase (PEG-SOD) on gastric mucosal injury and survival in an animal model of hemorrhagic shock and tissue trauma. Reproducible tissue trauma was produced by IM injection of turpentine (1.4 microliters/g). A standardized hemorrhagic shock model with an LD 90 was employed. This model consisted of the following sequence of events: phlebotomy to 60 per cent blood volume, 45-minute shock period, resuscitation using Lactated Ringers (LR) at two times shed volume over 60 minutes. Twenty rats were randomly assigned to receive LR (control) or PEG-SOD (5.36 mg/kg). Immediately following the death or at 72 hours, the stomach was removed. Computer image analysis was used to determine the lesion area as a per cent of total gastric mucosal surface area. Our results show no statistical difference in gastric mucosal lesion area between groups (1.83% vs 1.75%, respectively). Survival at 72 hours was significantly higher for PEG-SOD animals vs controls (70% vs 10%, P = 0.0001). This data suggests that IV administration of PEG-SOD during resuscitation is a potentially effective means of improving survival following severe hemorrhagic shock and tissue injury.

Soluble cytokine receptors and receptor antagonists are sequentially released after trauma.

Cytokine receptors and receptor antagonists (RAs) have been identified in trauma patients. We hypothesized that after traumatic injury, a sequential release of soluble cytokine receptors and RAs may exist that mirrors the release of the primary cytokines themselves. Twenty-two patients were included in the study: 14 males and 8 females. The mean age was 30.1 +/- 12.5 (range, 19 to 71), and the mean Injury Severity Score was 28.7 +/- 12.6 (range, 4 to 57). There were 15 survivors and 7 nonsurvivors. Samples were collected on arrival to the emergency department and at serial intervals for up to 7 days. Monoclonal antibody enzyme-linked immunosorbent assay kits to tumor necrosis factor (TNF), soluble TNF-receptor (sTNF-R) 55 kd and 75 kd, interleukin (IL)-1 and IL-1 RA, and IL-2 and IL-2r were used. Sera from 22 healthy individuals were used as normal controls. No TNF, IL-1, or IL-2 could be detected in any patient sera after injury. Control levels for the soluble cytokine receptors and RAs were as follows: sTNF-R 55 kd, 607 +/- 89 pg/mL; sTNF-R 75 kd, 2,141 +/- 169 pg/mL; IL-1 RA, 291 +/- 35 pg/mL; and IL-2r, 426 +/- 53 U/mL. In trauma patients, both 55 kd and 75 kd sTNF-R were significantly elevated on arrival to the emergency department, with values of 2,441 +/- 506 pg/mL (p < 0.001) and 4,736 +/- 537 pg/mL (p < 0.001), respectively.(ABSTRACT TRUNCATED AT 250 WORDS)

Respiratory distress in traumatized and burned children.

Incidence and significance of respiratory failure after trauma in children was the subject of this study. One thousand nine hundred eighty-nine pediatric trauma patients (aged 18 years or less) were treated at the authors' level I trauma center between 1985 and 1993. Of these, 364 (18%) were intubated. Their mechanisms of injury were: motor vehicle accidents in 93 (25%), pedestrians struck by vehicles in 93 (25%), motorcycle or bicycle accidents in 55 (15%), gunshot and stab wounds in 43 (12%), major burns (> 20% BSA) in 31 (9%), 14 of whom also had smoke inhalation, falls in 25 (7%), sport-related injuries in 9 (2%), and child abuse in 8 (2%). Average injury severity score of intubated patients was 27.0 +/- 21.4. Average trauma score was 11.7 +/- 4.1. Of the intubated patients, 248 (68%) had head injuries, 153 (42%) chest injuries, and 114 (31%) abdominal and pelvic injuries. Ninety-three (25%) of intubated patients died within 5 days of injury: 70 of head injury, 23 of multiple major organ injury. Intubation was required for more than 5 days in 77 patients (21%); 50 (14%) of these patients met criteria for respiratory distress syndrome (RDS): 12 (24% of RDS patients) died. Two of the deaths were multiply traumatized patients, and 10 were patients with burns and smoke inhalation. The authors conclude that RDS is uncommonly the cause of death in pediatric trauma patients. Burned patients with RDS are an exceptional group, with significant mortality.

A method to determine the adequacy of resuscitation using tissue oxygen monitoring.

The change in tissue PO2 in response to an increased inspired O2 challenge may be related to the state of cellular oxygenation, and hence the adequacy of resuscitation. To test this hypothesis, we measured tissue PO2 during inspired O2 challenges in 29 injured patients during acute resuscitation or intensive care unit monitoring. The O2 challenge test had 100% sensitivity and specificity in detecting flow-dependent O2 consumption in invasively monitored patients in the intensive care unit. During acute resuscitation, 60% of patients had negative initial O2 challenge test results, indicating that flow-dependent O2 consumption might have been present. Of nine such patients, five had subsequent positive O2 challenge test results after fluid resuscitation, indicating successful resuscitation. Four patients (27% of acute resuscitations), however, had repeatedly negative findings, possibly indicating persistent inadequate cellular oxygenation despite fluid resuscitation. Other commonly measured variables did not differentiate these patients. Monitoring of tissue PO2 during an inspired O2 challenge may be a useful test for determining the adequacy of resuscitation from hypovolemic shock.

Radiation exposure from cervical spine radiographs.

Radiation exposure to hospital personnel during 41 cervical spine radiographs of 30 multiply injured patients was prospectively evaluated. A digital dosimeter was attached to the exposed torso of personnel applying upper extremity traction or managing the airway. Radiation exposure was measured during each radiograph. Any exposure of one or more milliroentgen was detectable. No radiograph resulted in a measurable radiation exposure. Multiple radiographs (up to five exposures) also did not register even the minimum recordable exposure, demonstrating that exposure is less than 1.0 mR per radiograph (P < .05). We conclude that hospital personnel, even those applying traction or managing the airway, are not at risk of significant radiation exposure at the time of cervical spine radiographs.

Continuous arteriovenous hemodiafiltration in postoperative and traumatic renal failure.

Management of acute renal failure (ARF) in surgical patients has relied on supportive measures including hemodialysis and peritoneal dialysis. An alternative technique currently available is continuous arteriovenous hemodiafiltration (CAVH-D). Records of 44 surgical patients with ARF who were treated with CAVH-D in our surgical intensive care unit from 1989 to 1992 were reviewed. Thirty-five patients underwent emergency operations, and 4 patients underwent elective operations. Thirty-three patients were hemodynamically unstable immediately prior to the institution of CAVH-D, making hemodialysis a contraindication. A total of 565 CAVH-D days with an average of 13 days per patient were evaluated. Seventeen patients survived, with recovery of renal function in 13 patients. Vascular access was obtained via 227 percutaneous femoral catheters and 4 Scribner shunts. Seven vascular complications occurred, including arteriovenous fistula, pseudoaneurysm, limb ischemia, femoral artery hemorrhage, and femoral vein thrombosis. Based on these data, we conclude that CAVH-D is a safe and effective alternative in surgical patients with ARF.

Pentoxifylline alone versus pentoxifylline combined with superoxide dismutase prolongs survival in a rat hemorrhagic shock model.

Pentoxifylline (PTX) and superoxide dismutase (SOD) have each proven effective in improving survival when administered during resuscitation in animal models of hemorrhagic shock. This study was conducted to determine if PTX and SOD combined would have synergistic effectiveness in the treatment of hemorrhagic shock. Sprague-Dawley rats (n = 40) were phlebotomized at 25 ml/kg for 2 min, then subjected to a 45-min ischemic period, and resuscitated with lactated Ringer's solution (LR) (50 ml/kg) over 1 h. This model resulted in 70% mortality over 72 h when resuscitation was with LR alone. Animals were randomized into groups to receive one of the following agents during resuscitation: PTX in LR, SOD in LR, a combination of PTX and SOD in LR, or LR alone. PTX or SOD alone were effective in prolonging survival. However, the combination of PTX and SOD did not prolong survival above LR control.

Emergency thoracotomy with lung resection following trauma.

Over a 7-year period, 9443 trauma patients were evaluated with 2934 (31%) sustaining chest trauma. Of these, 347 (12%) patients required thoracotomy, with 12 patients undergoing emergency lung resection. Mean age was 23.1 years with mean Injury Severity Score of 32. Mechanism of injury was blunt in three (25%), gunshot wound in seven (58%), and stab wound in two (17%). Associated injuries included head injury in two (17%), intra-abdominal injury requiring laparotomy in four (33%), cardiac injury in three (25%), and great vessel injury in one (8%). Indications for operation included persistent hemorrhage in 11 and suspected tracheobronchial disruption in one. Non-anatomic lung resection was performed in five patients, lobectomy in three patients, and pneumonectomy in four patients. Overall mortality was 33 per cent: 20 per cent for non-anatomical lung resection, 33 per cent for lobectomy, and 50 per cent for pneumonectomy. All survivors fully recovered except for one patient with an associated head injury. Our experience supports the selective use of lung resection, including pneumonectomy, to immediately control hemorrhage and to impact survival in severe chest trauma.

Orotracheal intubation in trauma patients with cervical fractures.

OBJECTIVE: To evaluate orotracheal intubation with in-line stabilization of the cervical spine for emergency airway treatment of trauma patients with cervical spine injuries. DESIGN: Of 7518 trauma patients examined, 81 patients with cervical spine injuries received emergency orotracheal intubation. All intubations were performed by experienced anesthesiologists, with a separate individual maintaining in-line stabilization. Neurologic examination was documented before and after intubation. RESULTS: Peripheral neurologic deficit was present from the outset in 20 patients. There were unstable cervical fractures in 38 patients with no neurologic deficit. Twenty-three patients were neurologically intact with fractures that were later judged stable. In no instance was there a deterioration of neurologic status following intubation. Peripheral neurologic deficits improved after intubation in four patients. CONCLUSION: Orotracheal intubation, performed with manual in-line stabilization by trained and experienced personnel, is a safe emergency procedure in patients with cervical fractures.