RESUMO
Pyothorax-associated lymphoma (PAL) develops decades after receiving artificial pneumothorax for pulmonary tuberculosis. The lymphomas, develop in tissue affected by long-standing severe inflammatory process. Most cases demonstrate diffuse large B-cell lymphoma. We present a patient with T-cell phenotype-positive and B-cell phenotype-negative (CD7+, CD43+, CD19-, and CD20-) PAL. Southern blot hybridization using immunglobulin heavy chain J region (IgH) gene probe revealed a monoclonal rearrangement, and hybridization using T-cell receptor beta chain (TCR) gene probe revealed a germline configuration. This indicates that the tumor origin was of B-lymphocytes. Chromosomal abnormality of the lymphoma was complicated. It suggested that many transformations occurred. In the transformation process, probably B-cell antigens were lost, and T-cell antigens were aberrantly expressed.
Assuntos
Antígenos CD19/biossíntese , Antígenos CD7/biossíntese , Antígenos CD , Linfócitos B/metabolismo , Empiema Pleural/metabolismo , Herpesvirus Humano 4/metabolismo , Linfoma/virologia , Idoso , Anticorpos Monoclonais/metabolismo , Antígenos CD20/biossíntese , Biomarcadores Tumorais , Southern Blotting , Aberrações Cromossômicas , Humanos , Imunoglobulinas/metabolismo , Leucossialina , Ativação Linfocitária , Masculino , Hibridização de Ácido Nucleico , Fenótipo , Sialoglicoproteínas/biossíntese , Linfócitos T/metabolismoRESUMO
We experienced two cases of infectious mononucleosis-like syndrome associated with human herpesvirus 6 (HHV-6). One of the patients had been under medication for depression and the other one for schizophrenia. Both of them were taking carbamazepine for more than a week along with the other drugs. The manifestation of the symptoms of those two were almost same, such as high fever, generalized eruption, liver dysfunction, lymph-adenopathy, and existence of atypical lymphocytes. Serological tests for EB virus, cytomegalovirus and herpes simplex virus showed no significant change while the tests for HHV-6 showed increased titers of IgG antibody during the courses. We also examined HHV-6 DNA by real time quantitative PCR tests for HHV-6, and they appeared significantly high in the peripheral blood samples.