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1.
Eur J Pharmacol ; 974: 176604, 2024 Jul 05.
Artigo em Inglês | MEDLINE | ID: mdl-38649090

RESUMO

Osteoporosis (OP) is a metabolic bone disease with a high incidence rate worldwide. Its main features are decreased bone mass, increased bone fragility and deterioration of bone microstructure. It is caused by an imbalance between bone formation and bone resorption. Ginsenoside is a safe and effective traditional Chinese medicine (TCM) usually extracted from ginseng plants, having various therapeutic effects, of which the effect against osteoporosis has been extensively studied. We searched a total of 44 relevant articles with using keywords including osteoporosis, ginsenosides, bone mesenchymal cells, osteoblasts, osteoclasts and bone remodeling, all of which investigated the cellular mechanisms of different types of ginsenosides affecting the activity of bone remodeling by mesenchymal stem cells, osteoblasts and osteoclasts to counteract osteoporosis. This review describes the different types of ginsenosides used to treat osteoporosis from different perspectives, providing a solid theoretical basis for future clinical applications.


Assuntos
Ginsenosídeos , Osteoporose , Ginsenosídeos/farmacologia , Ginsenosídeos/uso terapêutico , Osteoporose/tratamento farmacológico , Humanos , Animais , Remodelação Óssea/efeitos dos fármacos , Osteoblastos/efeitos dos fármacos , Osteoclastos/efeitos dos fármacos
2.
J Colloid Interface Sci ; 314(2): 510-3, 2007 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-17618644

RESUMO

Sphere- and rod-shaped Zn(2)SiO(4):Mn(2+) phosphor nanocrystals were synthesized at 230 degrees C. The process consists of tuning the surfactant concentration in the oil/surfactant/ethanol system. Powder X-ray (XRD) and transmission electron microscopy (TEM) were used to characterize the phase purity, size and morphology. Photoluminescent (PL) spectra were collected and analyzed. Fourier transform infrared (FT-IR) spectra of the samples indicate the removal of surfactant in the phosphor nanoparticles. As a result, the sphere-shaped phosphor nanoparticles of 100 nm in size can be redispersed in ethanol ultrasonically. The suspension maintain stable for over 48 h.


Assuntos
Manganês/química , Fósforo/química , Silicatos/química , Zinco/química , Etanol/química , Luz , Luminescência , Nanopartículas Metálicas/química , Microscopia Eletrônica de Transmissão , Nanopartículas , Espectrofotometria , Espectroscopia de Infravermelho com Transformada de Fourier , Temperatura , Fatores de Tempo , Difração de Raios X
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