Association between dietary patterns and prediabetes risk in a middle-aged Chinese population.

BACKGROUND: Information regarding dietary patterns associated with prediabetes in the Chinese population is lacking. The objective of the present study was to explore the association between major dietary patterns and the risk of prediabetes in a middle-aged Chinese population. METHODS: A total of 1761 participants (aged 45 to 59 years) were recruited in Hangzhou city, the capital of Zhejiang Province, China from June 2015 to December 2016. Dietary information was obtained by interview using a 138-item, validated semi-quantitative food frequency questionnaire (SQFFQ). Multivariate logistic regression models were used to analyze the associations between dietary patterns and the risk of prediabetes with adjustment of potential confounding variables. RESULTS: Three dietary patterns were ascertained by factor analysis and labeled as traditional southern Chinese, Western, and grains-vegetables patterns. After controlling of the potential confounders, participants in the top quartile of the Western pattern scores had greater odds ratio (OR) for prediabetes (OR = 1.54; 95% confidence interval (CI):1.068-2.059; P = 0.025) than did those in the bottom quartile. Compared with those in the bottom quartile, participants in the top quartile of the grains-vegetables pattern scores had a lower OR for prediabetes (OR = 0.83; 95% CI:0.747-0.965; P = 0.03). Besides, no statistically significant association was observed in the association between the traditional southern Chinese pattern and prediabetes risk (P > 0.05). CONCLUSIONS: The findings of this study showed that the Western pattern was associated with higher risk, and the grains-vegetables pattern was associated with lower risk of prediabetes. Future prospective studies are required to validate our findings.

Association between Dietary Patterns and the Risk of Hypertension among Chinese: A Cross-Sectional Study.

UNLABELLED: Epidemiological studies of different dietary patterns and the risk of hypertension among a middle-aged Chinese population remain extremely scare. Thus, the aim of this study was to identify dietary patterns and investigate the relationship between dietary patterns and the risk of hypertension among Chinese adults aged 45-60 years. The present cross-sectional study includes 2560 participants who reported their dietary intake using a validated food frequency questionnaire (FFQ). Dietary patterns were identified using factor analysis. Anthropometric measurements were obtained using standardized procedures. We used log-binomial regression analysis to examine the associations between dietary patterns and hypertension risk. Four major dietary patterns were identified and labeled as traditional Chinese, animal food, western fast-food, and high-salt patterns. After adjusting for potential confounders, participants in the highest quartile of animal food pattern scores had a greater prevalence ratio (PR) for hypertension (PR = 1.26; 95% confidence interval (CI): 1.064-1.727; p < 0.05) in comparison to those from the lowest quartile. Compared with the lowest quartile of high-salt pattern, the highest quartile had a higher prevalence ratio for hypertension (PR = 1.12; 95% CI: 1.013-1.635; p < 0.05). CONCLUSIONS: Our findings indicated that animal food and high-salt patterns were associated with increased risk of hypertension, while traditional Chinese and western fast-food patterns were not associated with the risk of hypertension. Further prospective studies are warranted to confirm these findings.

[Fluorescence and visible spectroscopic studies on interaction of beta-cyclodextrin-thionine inclusion complex with DNA].

The inclusion of beta-cyclodextrin (CD) for thionine (TH) and the interaction of DNA with CD-TH inclusion complex were investigated by fluorescence and visible absorption spectrometry. TH with beta-CD formed a 1 : 1 inclusion complex with the stability constant of 527 L x mol(-1) (visible spectrometry)/444 L x mol(-1) (fluorescence) in the pH 7.2 PBS buffer solutions. The addition of DNA makes the absorbance of the inclusion complex decrease and the absorption spectrum shift toward long wavelengths. The fluorescence experiments indicated that the presence of DNA makes the emission peak of CD-TH shift toward short wavelengths and the fluorescence of inclusion complex quench, and the quenching constant was calculated to be 6.12 x 10(4) L x mol(-1) by Stern-Volmer method. All the data confirmed that CD-TH reacted with DNA in intercalative mode, and the binding numbers and the binding constant were estimated to be 1 and 3.47 X 10(4) L x mol(-1) by spectrophotometry.