Suicide in Brisbane--a retrospective psychosocial study.

A consecutive series of 135 suicides is described, this being the total which occurred during one year in Brisbane from 1 March 1973 to 28 February 1974, resulting in a rate of 16 per 100,000. The clinical and social characteristics of the suicides are described. Important contributing factors were depressive illness (55%), physical illness (52%), and drug dependency (34%). About half of the suicides were taking prescribed medication and about a third had been in contact with a doctor shortly before death. Social isolation or loss appeared to contribute to the suicide risk. The study confirms the importance of the recognition and treatment of depressive illness in attempting to prevent suicide and draws attention to the significant contribution of physical illness, especially when affecting the nervous system or gastrointestinal tract, and the importance of the role of alcohol and/or barbiturate dependency.

Cerebellar calcification--ultrastructure and histochemistry.

The histochemistry and ultrastructure of calcified cerebellar deposits described by Tonge et al. (1977) are reported. The deposits were located by electron microscopy in the walls of blood vessels outside the basement membrane and, in most lesions, consisted of short fibrillar material arranged in multiple lamellae. A number of nonlaminated small bodies were present also. The material coated the vessel walls discontinuously with major and minor protrusions into adjacent nervous tissue. Histochemical analysis detected the presence of sialopolysaccharides in the lesions in adults and in a case of plumbism in a child, with minor differences in the type of sialic acid. X-ray fluorescence analysis supported by histochemical data indicated that, initially, the calcium was bound to the sialic acid and that calcium phosphate appeared in the lesions at a later date. The authors conclude that the lesion is formed by elaboration of sialopolysaccharides at the site but the possibility was not excluded that the polysaccharide may have been derived from a transudate across the vessel wall.

Cerebellar calcification: a possible marker of lead poisoning.

An unusual form of calcification in the cerebellum has been observed in routine autopsies in Queensland over the past 30 years. In 4 surveys carried out at intervals between 1951 and 1976 the lesion has been found microscopically in 10 to 15% of autopsies. There is a significant correlation between cerebellar calcification and raised lead levels in bone.