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INTRODUCTION AND IMPORTANCE: Undifferentiated pleomorphic sarcoma (UPS), previously known as malignant fibrous histiocytoma (MFH), is a highly aggressive soft tissue sarcoma characterized by its pleomorphic histology and lack of differentiation. CASE PRESENTATION: A 35-year-old man visited our oncology department with a complaint of a growing mass in his left buttock area. The mass had been increasing in size for the past six months, affected by local and systemic infection. While it was initially painless, the patient started feeling discomfort during sitting and physical activities a few weeks, but later the complication of tumor became more aggressive. CLINICAL DISCUSSION: UPS can arise in various anatomical sites, including the extremities, trunk, retroperitoneum, and head and neck region. Clinically, UPS may present as a rapidly growing mass, often with pain and limited range of motion. However, the presentation may vary depending on the site of origin. Treatment for UPS typically involves surgical resection, aiming to remove the tumor completely. Depending on the size, location, and aggressiveness of the tumor, additional treatments such as radiation therapy or chemotherapy may be recommended. CONCLUSION: Undifferentiated pleomorphic sarcoma (UPS) represents a rare and aggressive soft tissue sarcoma requiring prompt and accurate diagnosis for appropriate management. With its non-specific clinical presentation and histological features, UPS can be challenging to differentiate from other soft tissue tumors.
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Background: Drug interactions can cause adverse reactions, from treatment inefficiency to serious treatment complications in the patient. Due to the complexity of drug therapy and the simultaneous use of several drugs and different drug groups, patients hospitalized in intensive care units are exposed to more drug interactions. Therefore, this study was conducted to investigate the frequency of drug interactions in patients hospitalized in the ICU. Methods: In this cross-sectional study, the files of 300 patients hospitalized in the ICU were examined. Drug interactions were determined using Lexicomp software and the book drug iteration facts. Data analysis was done using SPSS 21 software. Findings: The findings showed that there were a total of 1121 cases of interference. Two hundred thirty-one (77%) patients had moderate interference, 94 (31.3%) patients had mild interference, and 67 patients (22.3%) had severe interference. One hundred eight patients had B-type interference, 223 C-type interference, 116 D-type interference, and 6 X-type interference, so most of the interactions are C-type interference. One hundred eighty-six patients had pharmacokinetic interference and 201 patients had pharmacodynamics interference. The highest interaction was between two drugs, heparin and aspirin with 58 cases. Conclusion: This study highlights the alarming frequency and types of drug interactions observed in ICU. The high prevalence of drug interactions emphasizes the need for improved medication management and vigilance in these critical care settings. Polypharmacy and certain drug combinations were identified as major contributing factors to the occurrence of drug interactions, which calls for regular medication reviews and cautious prescribing practices.
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INTRODUCTION AND IMPORTANCE: Breast sarcomas are scarce, histologically heterogeneous with nonepithelial malignancies that originate from the connective tissue within the parenchyma of breast. They can develop primarily, after radio-therapy (RT), or secondary due to chronic condition, including metastatic cancers. CASE PRESENTATION: The present case report concerns 58-year-old women which was unbeknown to her malignancy in the early stages, until the mass became substantial in size. Chemotherapy and also radiotherapy were not effective, and the growth of tumor could not be prevented which the patient eventually died, due to respiratory complications. CLINICAL DISCUSSION: Breast sarcomas are categorized in very rare malignancies, and the mortality of these types of cancers are significantly high as they often are not diagnosed in early stages. Based on the location and condition of the malignant tumor, therapeutic methods considered as chemotherapy, radiotherapy, and surgery. CONCLUSION: In advance stages of breast sarcoma, chemotherapy, radiotherapy, and even surgery cannot be effectual. Therefore, periodical evaluation of breast wellness by diagnostic methods are recommended to all adult women.
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INTRODUCTION AND IMPORTANCE: Refractory diabetic foot ulcers (DFUs) are still a major health problem and can lead to death. CASE PRESENTATION: The present case reports a 45-year-old man with an 8-year history of type 2 diabetes who has had left refractory DFU for a year on the left heel with a size of 6 × 3 × 1 cm. The patient's ulcers were infected with Staphylococcus aureus. Despite the routine DFU care (normal saline dressing twice a day and intravenous antibiotic therapy), the patient did not recover from DFU using standard methods. The patient was referred to our wound management team. In the first step, the necrotic tissues of his foot ulcer were irrigated and debrided using mechanical debridement and saline. Next, the patient underwent a 70 µg/dL dose of ozone therapy over a 30-day period in 10 sessions (one 20-minute session every 3 days). Between each session, the patient's wound was wrapped in silver-containing gauze bandages. After two months, the patient's DFUs healed, and he was discharged from our service in good condition. CLINICAL DISCUSSION: DFU can lead to infection, amputation, and even patient death. Therefore, effective treatment methods are very important for managing DFUs. CONCLUSION: This case report study was shown that the ozone therapy is an effective approach to improve the healing of refractory DFUs and prevent foot amputation. Therefore, wound-care teams can utilize it as an adjunct to the standard methods of DFU treatment.
