Assuntos
Vasculite por IgA/terapia , Infecções Pneumocócicas/complicações , Choque Séptico/complicações , Esplenectomia , Injúria Renal Aguda/etiologia , Injúria Renal Aguda/terapia , Idoso , Coagulação Intravascular Disseminada/complicações , Coagulação Intravascular Disseminada/terapia , Humanos , Vasculite por IgA/etiologia , Masculino , Infecções Pneumocócicas/terapia , Choque Séptico/terapia , SíndromeRESUMO
Thiazolidinediones (TZDs), potent peroxisome proliferator-activated receptor gamma ligands, have been shown to improve endothelial function in vascular diseases. We investigated the effects of pioglitazone, a TZD, on monocyte-endothelial interaction under flow and found that pretreatment (20 mumol/l, 48 h) significantly reduced U937 adhesion to human umbilical vein endothelial cells. Integrin expression was not altered, however, the activation of RhoA GTPase was significantly reduced after treatment. Further, pioglitazone treatment significantly reduced phosphorylation of focal adhesion kinase (FAK) at 925Y, but not at 397Y, suggesting a specific role in FAK-dependent signaling. These results indicate a novel anti-inflammatory role for this compound.