Thermo-Optoplasmonic Single-Molecule Sensing on Optical Microcavities.

Whispering-gallery-mode (WGM) resonators are powerful instruments for single-molecule sensing in biological and biochemical investigations. WGM sensors leveraged by plasmonic nanostructures, known as optoplasmonic sensors, provide sensitivity down to single atomic ions. In this article, we describe that the response of optoplasmonic sensors upon the attachment of single protein molecules strongly depends on the intensity of WGM. At low intensity, protein binding causes red shifts of WGM resonance wavelengths, known as the reactive sensing mechanism. By contrast, blue shifts are obtained at high intensities, which we explain as thermo-optoplasmonic (TOP) sensing, where molecules transform absorbed WGM radiation into heat. To support our conclusions, we experimentally investigated seven molecules and complexes; we observed blue shifts for dye molecules, amino acids, and anomalous absorption of enzymes in the near-infrared spectral region. As an example of an application, we propose a physical model of TOP sensing that can be used for the development of single-molecule absorption spectrometers.

SARS-CoV-2 Tests: Bridging the Gap between Laboratory Sensors and Clinical Applications.

This review covers emerging biosensors for SARS-CoV-2 detection together with a review of the biochemical and clinical assays that are in use in hospitals and clinical laboratories. We discuss the gap in bridging the current practice of testing laboratories with nucleic acid amplification methods, and the robustness of assays the laboratories seek, and what emerging SARS-CoV-2 sensors have currently addressed in the literature. Together with the established nucleic acid and biochemical tests, we review emerging technology and antibody tests to determine the effectiveness of vaccines on individuals.

Whispering-gallery microlasers for cell tagging and barcoding: the prospects for in vivo biosensing.

Researchers in the field of whispering-gallery-mode (WGM) microresonators have proposed biointegrated low-threshold WGM lasers, to enable large-scale parallel single-cell tracking and barcoding. Although the reported devices have so far been primarily investigated in model applications, most recent results represent important steps towards the development of in vivo tags and sensors that utilize the unique and narrow spectral features of miniature WGM lasers.

Review of biosensing with whispering-gallery mode lasers.

Lasers are the pillars of modern optics and sensing. Microlasers based on whispering-gallery modes (WGMs) are miniature in size and have excellent lasing characteristics suitable for biosensing. WGM lasers have been used for label-free detection of single virus particles, detection of molecular electrostatic changes at biointerfaces, and barcode-type live-cell tagging and tracking. The most recent advances in biosensing with WGM microlasers are described in this review. We cover the basic concepts of WGM resonators, the integration of gain media into various active WGM sensors and devices, and the cutting-edge advances in photonic devices for micro- and nanoprobing of biological samples that can be integrated with WGM lasers.

Rectangular SNAP microresonator fabricated with a femtosecond laser.

Surface nanoscale axial photonics (SNAP) microresonators, which are fabricated by nanoscale effective radius variation (ERV) of the optical fiber with subangstrom precision, can be potentially used as miniature classical and quantum signal processors, frequency comb generators, and ultraprecise microfluidic and environmental optical sensors. Many of these applications require the introduction of nanoscale ERV with a large contrast α, which is defined as the maximum shift of the fiber cutoff wavelength introduced per unit length of the fiber axis. The previously developed fabrication methods of SNAP structures, which used focused CO2 and femtosecond laser beams, achieved α∼0.02 nm/µm. Here we develop a new, to the best of our knowledge, fabrication method of SNAP microresonators with a femtosecond laser, which allows us to demonstrate a 50-fold improvement of previous results and achieve α∼1 nm/µm. Furthermore, our fabrication method enables the introduction of ERV that is several times larger than the maximum ERV demonstrated previously. As an example, we fabricate a rectangular SNAP resonator and investigate its group delay characteristics. Our experimental results are in good agreement with theoretical simulations. Overall, the developed approach allows us to reduce the axial scale of SNAP structures by an order of magnitude.

SNAP microresonators introduced by strong bending of optical fibers.

We introduce a new method of the fabrication of surface nanoscale axial photonic (SNAP) microresonators through strong bending of an optical fiber. We experimentally demonstrate that geometric deformation and refractive index variation induced by bending is sufficient for the formation of a SNAP bottle resonator with nanoscale effective radius variation (ERV) along the fiber axis. In our experiment, we bend the optical fiber into a loop and investigate the properties of the fabricated tunable bottle resonator as a function of the loop dimensions. We find that the introduced ERV is approximately proportional to the local curvature of the loop, while the ERV maximum is proportional to the maximum of the loop curvature squared. The advantages of the demonstrated method are its simplicity, robustness, and ability to mechanically tune introduced resonant structures. This is of crucial importance for the creation of robust and tunable SNAP devices for applications in optical classical and quantum signal processing and ultraprecise sensing.

Boosting Terahertz Photoconductive Antenna Performance with Optimised Plasmonic Nanostructures.

Advanced nanophotonics penetrates into other areas of science and technology, ranging from applied physics to biology, which results in many fascinating cross-disciplinary applications. It has been recently demonstrated that suitably engineered light-matter interactions at the nanoscale can overcome the limitations of today's terahertz (THz) photoconductive antennas, making them one step closer to many practical implications. Here, we push forward this concept by comprehensive numerical optimization and experimental investigation of a log-periodic THz photoconductive antenna coupled to a silver nanoantenna array. We shed light on the operation principles of the resulting hybrid THz antenna, providing an approach to boost its performance. By tailoring the size of silver nanoantennas and their arrangement, we obtain an enhancement of optical-to-THz conversion efficiency 2-fold larger compared with previously reported results for similar structures, and the strongest enhancement is around 1 THz, a frequency range barely achievable by other compact THz sources. We also propose a cost-effective fabrication procedure to realize such hybrid THz antennas with optimized plasmonic nanostructures via thermal dewetting process, which does not require any post processing and makes the proposed solution very attractive for applications.

Enhancement of Raman scattering of a gaseous medium near the surface of a silver holographic grating.

The Letter demonstrates a possibility to enhance the Raman scattering of a gaseous medium due to an enhanced electromagnetic field caused by the excitation of propagating surface plasmon polaritons (PSPPs) on a silver holographic grating. Efficiency of collinear and noncollinear schemes of PSPP excitation on a metal-gaseous medium interface was studied. When using a collinear scheme, we registered an eightfold enhancement of the Raman scattering of atmospheric nitrogen and oxygen, where the average gain near the PSPP-active surface was ∼4×103.