RESUMO
On rare occasions, skin lesions are the first local of metastatic manifestation of internal malignancies. In case of no previous diagnosis of these tumors, the approach of suspicious skin lesions becomes a challenge, especially in differentiating cutaneous metastases and adnexal primary neoplasms. Currently, besides epidemiologic, dermoscopic and histopathologic aspects, the evaluation also integrates immunohistochemical exams and cell markers such as p40 and p63, highly specific for skin metastases. This article describes the case of cutaneous metastases as the sole obvious sign of breast cancer in a previously asymptomatic woman. The diagnosis was made by the finding of neoplastic cells in the dermis and immunohistochemistry compatible with ductal carcinoma.
Assuntos
Neoplasias da Mama/patologia , Carcinoma Ductal de Mama/secundário , Neoplasias Cutâneas/secundário , Idoso de 80 Anos ou mais , Diagnóstico Diferencial , Feminino , Humanos , Imuno-Histoquímica , Neoplasias de Anexos e de Apêndices Cutâneos/patologia , Pele/patologiaRESUMO
Pigmented purpuric dermatoses are chronic vascular inflammatory conditions characterized by the presence of pigmented macules. Among its different presentations, lichen aureus is distinguished by the lichenoid conformation of its plaques and the predilection for lower limb involvement. Its segmented form is rare and difficult to control, especially in cases of symptomatic lesions. We report a rare case of segmental lichen aureus with six years of evolution associated with light itching. We also discuss the main therapeutic approaches to control the disease.
Assuntos
Erupções Liquenoides/patologia , Betametasona/uso terapêutico , Feminino , Glucocorticoides/uso terapêutico , Humanos , Erupções Liquenoides/terapia , Metoxaleno/uso terapêutico , Pessoa de Meia-Idade , Fármacos Fotossensibilizantes/uso terapêutico , Luz SolarRESUMO
Abstract: Pigmented purpuric dermatoses are chronic vascular inflammatory conditions characterized by the presence of pigmented macules. Among its different presentations, lichen aureus is distinguished by the lichenoid conformation of its plaques and the predilection for lower limb involvement. Its segmented form is rare and difficult to control, especially in cases of symptomatic lesions. We report a rare case of segmental lichen aureus with six years of evolution associated with light itching. We also discuss the main therapeutic approaches to control the disease.
Assuntos
Humanos , Feminino , Pessoa de Meia-Idade , Erupções Liquenoides/patologia , Luz Solar , Betametasona/uso terapêutico , Fármacos Fotossensibilizantes/uso terapêutico , Erupções Liquenoides/terapia , Glucocorticoides/uso terapêutico , Metoxaleno/uso terapêuticoRESUMO
Abstract: On rare occasions, skin lesions are the first local of metastatic manifestation of internal malignancies. In case of no previous diagnosis of these tumors, the approach of suspicious skin lesions becomes a challenge, especially in differentiating cutaneous metastases and adnexal primary neoplasms. Currently, besides epidemiologic, dermoscopic and histopathologic aspects, the evaluation also integrates immunohistochemical exams and cell markers such as p40 and p63, highly specific for skin metastases. This article describes the case of cutaneous metastases as the sole obvious sign of breast cancer in a previously asymptomatic woman. The diagnosis was made by the finding of neoplastic cells in the dermis and immunohistochemistry compatible with ductal carcinoma.
Assuntos
Humanos , Feminino , Idoso de 80 Anos ou mais , Neoplasias Cutâneas/secundário , Neoplasias da Mama/patologia , Carcinoma Ductal de Mama/secundário , Pele/patologia , Imuno-Histoquímica , Neoplasias de Anexos e de Apêndices Cutâneos/patologia , Diagnóstico DiferencialRESUMO
Chromoblastomycosis is a chronic fungal infection of the epidermis, dermis and subcutaneous tissue, in which the most common etiologic agent in Brazil is Fonsecaea pedrosoi. In more advanced cases we found many difficulties in their treatment, and therefore, we report a case of extensive and severe chromoblastomycosis, with therapeutical failure of first choice treatments, but good response to voriconazole.
Assuntos
Antifúngicos/uso terapêutico , Cromoblastomicose/tratamento farmacológico , Voriconazol/uso terapêutico , Humanos , Masculino , Pessoa de Meia-Idade , Resultado do TratamentoRESUMO
The Henoch-Schönlein purpura is the vasculitis associated with deposits of immunoglobulin A in small vessels. Its association with cytoplasmic antineutrophil cytoplasmic antibodies is possible, but rare. This vasculitis is uncommon in adults and the main clinic manifestations are purpuric lesions in lower limbs with gastrointestinal symptoms and renal involvement. The present work describes a rare case of Henoch-Schönlein purpura in an adult with cytoplasmic antineutrophil cytoplasmic antibodies.
Assuntos
Anticorpos Anticitoplasma de Neutrófilos/análise , Vasculite por IgA/diagnóstico , Técnica Direta de Fluorescência para Anticorpo , Humanos , Masculino , Adulto JovemRESUMO
Abstract: The Henoch-Schönlein purpura is the vasculitis associated with deposits of immunoglobulin A in small vessels. Its association with cytoplasmic antineutrophil cytoplasmic antibodies is possible, but rare. This vasculitis is uncommon in adults and the main clinic manifestations are purpuric lesions in lower limbs with gastrointestinal symptoms and renal involvement. The present work describes a rare case of Henoch-Schönlein purpura in an adult with cytoplasmic antineutrophil cytoplasmic antibodies.
Assuntos
Humanos , Masculino , Adulto Jovem , Vasculite por IgA/diagnóstico , Anticorpos Anticitoplasma de Neutrófilos/análise , Técnica Direta de Fluorescência para AnticorpoRESUMO
Abstract: Chromoblastomycosis is a chronic fungal infection of the epidermis, dermis and subcutaneous tissue, in which the most common etiologic agent in Brazil is Fonsecaea pedrosoi. In more advanced cases we found many difficulties in their treatment, and therefore, we report a case of extensive and severe chromoblastomycosis, with therapeutical failure of first choice treatments, but good response to voriconazole.
Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , Cromoblastomicose/tratamento farmacológico , Voriconazol/uso terapêutico , Antifúngicos/uso terapêutico , Resultado do TratamentoRESUMO
The granulomatosis with polyangiitis, initially known as Wegener's granulomatosis, is a small and medium vessels vasculitis. It's classic form presents a triad: necrotizing granuloma of respiratory tract, necrotizing cutaneous vasculitis and glomerulonephritis. This vasculitis has cytoplasmic antineutrophil antibodies as signal. This work illustrates a case, of multisystemic rare disease, in which the segment and treatment were considered satisfactory for symptoms remission.
Assuntos
Granulomatose com Poliangiite/patologia , Úlcera Cutânea/patologia , Adolescente , Corticosteroides/administração & dosagem , Dermatoses Faciais/tratamento farmacológico , Dermatoses Faciais/patologia , Feminino , Granulomatose com Poliangiite/tratamento farmacológico , Humanos , Dermatoses da Perna/tratamento farmacológico , Dermatoses da Perna/patologia , Necrose/patologia , Úlcera Cutânea/tratamento farmacológico , Terminologia como AssuntoRESUMO
The granulomatosis with polyangiitis, initially known as Wegener's granulomatosis, is a small and medium vessels vasculitis. It's classic form presents a triad: necrotizing granuloma of respiratory tract, necrotizing cutaneous vasculitis and glomerulonephritis. This vasculitis has cytoplasmic antineutrophil antibodies as signal. This work illustrates a case, of multisystemic rare disease, in which the segment and treatment were considered satisfactory for symptoms remission.
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