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1.
Rev Soc Bras Med Trop ; 52: e20180236, 2019 01 17.
Artigo em Inglês | MEDLINE | ID: mdl-30652793

RESUMO

In Brazil, meglumine antimoniate is the first drug of choice for mucosal leishmaniasis treatment followed by amphotericin B and pentamidine isethionate. We report the case of a patient with severe mucosal lesions caused by Leishmania (Viannia) braziliensis that were difficult to treat. Over a 14-year period, the patient showed low adherence and three treatment attempts with meglumine antimoniate failed. Additionally, there was an unsatisfactory response to liposomal amphotericin B and nephrotoxicity when using amphotericin B deoxycholate that persisted after new treatment attempt with liposomal amphotericin B. Finally, healing was achieved with pentamidine isethionate and maintained during nine months of monitoring.


Assuntos
Antiprotozoários/uso terapêutico , Leishmania braziliensis/efeitos dos fármacos , Leishmaniose Mucocutânea/tratamento farmacológico , Pentamidina/uso terapêutico , Humanos , Masculino , Pessoa de Meia-Idade , Resultado do Tratamento
2.
Rev. Soc. Bras. Med. Trop ; 52: e20180236, 2019. graf
Artigo em Inglês | LILACS | ID: biblio-977116

RESUMO

Abstract In Brazil, meglumine antimoniate is the first drug of choice for mucosal leishmaniasis treatment followed by amphotericin B and pentamidine isethionate. We report the case of a patient with severe mucosal lesions caused by Leishmania (Viannia) braziliensis that were difficult to treat. Over a 14-year period, the patient showed low adherence and three treatment attempts with meglumine antimoniate failed. Additionally, there was an unsatisfactory response to liposomal amphotericin B and nephrotoxicity when using amphotericin B deoxycholate that persisted after new treatment attempt with liposomal amphotericin B. Finally, healing was achieved with pentamidine isethionate and maintained during nine months of monitoring.


Assuntos
Humanos , Masculino , Pentamidina/uso terapêutico , Leishmania braziliensis/efeitos dos fármacos , Leishmaniose Mucocutânea/tratamento farmacológico , Antiprotozoários/uso terapêutico , Resultado do Tratamento , Pessoa de Meia-Idade
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