Integración sensorial: beneficios y efectividad del abordaje terapéutico en los trastornos del procesamiento sensorial / Sensory integration: benefits and effectiveness of therapeutic management in sensory processing disorders

En la actualidad, el hecho de que existen dificultades de integración sensorial de base neurológica y que éstas condicionan gravemente el desarrollo de las personas que las sufren, está aceptado y reconocido como evidente por la gran mayoría de profesionales del campo sociosanitario. No obstante, en cuanto a tratamientos efectivos para abordarlas, hay más controversia y desconocimiento, ya que existe la crítica generalizada de que las intervenciones alternativas a la farmacológica no constan con la suficiente evidencia científica que demuestre de forma cuantitativa y empírica los resultados obtenidos a través de ella. Consecuentemente, cuando los síntomas y repercusión en la calidad de vida derivados de una integración sensorial distorsionada son realmente limitantes para la persona, se acaba recurriendo al tratamiento farmacológico como único abordaje posible, con los efectos secundarios que ello conlleva, debido al desconocimiento de enfoques terapéuticos efectivos, como la terapia ocupacional basada en el enfoque de la integración sensorial (AU)

Today, the fact that sensory integration difficulties with a neurological basis exist and that they seriously condition the development of those individuals who suffer from them is widely accepted and acknowledged as being obvious by the vast majority of professionals working in the field of community healthcare. However, less is known and there is more controversy about effective treatments that can be applied to them. This is because many professionals criticise the fact that there is not enough scientific evidence to prove, both quantitatively and empirically, the outcomes of the interventions implemented as alternatives to pharmacological therapy. Consequently, when the symptoms and repercussions on the quality of life deriving from a distorted sensory integration are really disabling for the person, pharmacological treatment is used as the only possible approach, with the side effects that this entails. The reason for this is largely the fact that little is known about other effective therapeutic approaches, such as occupational therapy based on sensory integration (AU)

A process analytical technology approach based on near infrared spectroscopy: tablet hardness, content uniformity, and dissolution test measurements of intact tablets.

Near infrared spectroscopy (NIRS) is a nondestructive analytical technique that enables simultaneous measurements of chemical composition (viz. the content in active pharmaceutical ingredient, API) and various physical properties (viz. tablet hardness and dissolution profile) in pharmaceutical tablets. In this work, partial least squares (PLS) calibration models and discriminant partial least squares (DPLS) classification models were constructed by using calibration sets consisting of laboratory samples alone. The laboratory samples were mixtures of the API and excipients that were pressed into tablets. API content, tablet hardness, and dissolution measurements of intact tablets were made by using three different calibration models that are fast--results can be obtained within a few seconds--, simple and robust--they involve minimal analyst intervention--, and clean--they use no toxic reagent and produce no toxic waste. Based on the results, the proposed NIR method is an effective alternative to current reference methods for the intended purpose. The advantages provided by NIR spectroscopy in this context confirm its potential for inclusion in process analytical technologies in the pharmaceutical industry.

Enantiomeric purity determination of ketoprofen by capillary electrophoresis: development and validation of the method.

A simple, fast capillary electrophoresis method for determining the total ketoprofen content in an oral pharmaceutical formulation is proposed. The addition of 75 mM of heptakis(tri- O-methyl)-beta-cyclodextrin to the background electrolyte allows the quantitation of the enantiomeric impurity of ( R)-(-)-ketoprofen contained in the formulation. A relative limit of detection is proposed as a measure of the lowest detectable enantiomeric impurity and the results show that the method can detect the minor enantiomer at levels as low as 0.04% in ( S)-(+)-ketoprofen. The chiral method was validated following ICH recommendations and the quality parameters obtained show the suitability of the proposed method. The analysis of samples examined during the course of a stability study under chiral and achiral conditions revealed that the total ketoprofen content did not change significantly with time and the enantiomeric impurity range was 0.1-0.4%.