Distribution and factors associated with salivary secretory leukocyte protease inhibitor concentrations.

OBJECTIVES: This cross-sectional study examined the distribution and correlates of salivary secretory leukocyte protease inhibitor (SLPI) concentrations within a multinational cohort of men. METHODS: Extracellular SLPI was measured in oral gargle cell supernatants of 378 men from three countries using an ELISA-based assay. Risk factor data were collected by a questionnaire. Factors associated with SLPI were assessed using linear and logistic regression for continuous and categorical SLPI, respectively. RESULTS: Among men aged 18-73 years, the median SLPI concentration was 492.0 ng ml-1 (range: 2.3-1919.9). In multivariable modeling, men in Brazil and younger men (18-30 years) were more likely to have higher levels of SLPI [adjusted odds ratio (aOR) 3.84; 95% confidence interval (CI): 1.94-7.59, and aOR 3.84; 95% CI: 1.98-7.43, respectively]. Men with a self-reported sexually transmitted diseases diagnosis in the past 6 months were more likely to have higher SLPI levels (aOR 2.98; 95% CI: 1.1-7.83) and men reporting bleeding/swollen gums were less likely to have higher SLPI (aOR 0.34; 95% CI: 0.15-0.79). Similar results were observed for linear regression models. CONCLUSIONS: Secretory leukocyte protease inhibitor concentrations varied significantly by country and decreased with increasing age. The interaction between SLPI, modifiable factors, and oral infections that influence cancer risk warrants further investigation.

Vectorial importance of triatominae bugs (Hemiptera: Reduviidae) in Guaymas, Mexico.

The study was conducted in Guaymas city, Sonora, in Northwestern Mexico. Triatomines were collected manually during daytime, within and around houses selected randomly, with one person searching for bugs during one hour per house. Collected bugs were identified and analyzed for Trypanosoma cruzi infection. From a total of 279 collected specimens there were 123 females, 65 males and 91 nymphs (entomological indexes: 63% infestation, 68.4% colonization, 8.5% density and 13.5% stacking). There were 251 (90%) triatominae bugs infected with T. cruzi, one of the highest natural infestation levels recorded in Mexico. The insects collected were identified as Triatoma rubida (91%) and T. recurva (9%). Previous reports for the same locality (1959) indicated the presence of T. rubida in the wild, we found T. rubida within houses, and T. recurva as a peridomestic bug. Unplanned housing developments in originally wild areas may have favored T. cruzi transmitters to migrate from the wild and into human dwellings.