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1.
Biomolecules ; 11(12)2021 11 29.
Artigo em Inglês | MEDLINE | ID: mdl-34944430

RESUMO

The prediction of microsatellite instability (MSI) using deep learning (DL) techniques could have significant benefits, including reducing cost and increasing MSI testing of colorectal cancer (CRC) patients. Nonetheless, batch effects or systematic biases are not well characterized in digital histology models and lead to overoptimistic estimates of model performance. Methods to not only palliate but to directly abrogate biases are needed. We present a multiple bias rejecting DL system based on adversarial networks for the prediction of MSI in CRC from tissue microarrays (TMAs), trained and validated in 1788 patients from EPICOLON and HGUA. The system consists of an end-to-end image preprocessing module that tile samples at multiple magnifications and a tissue classification module linked to the bias-rejecting MSI predictor. We detected three biases associated with the learned representations of a baseline model: the project of origin of samples, the patient's spot and the TMA glass where each spot was placed. The system was trained to directly avoid learning the batch effects of those variables. The learned features from the bias-ablated model achieved maximum discriminative power with respect to the task and minimal statistical mean dependence with the biases. The impact of different magnifications, types of tissues and the model performance at tile vs patient level is analyzed. The AUC at tile level, and including all three selected tissues (tumor epithelium, mucin and lymphocytic regions) and 4 magnifications, was 0.87 ± 0.03 and increased to 0.9 ± 0.03 at patient level. To the best of our knowledge, this is the first work that incorporates a multiple bias ablation technique at the DL architecture in digital pathology, and the first using TMAs for the MSI prediction task.


Assuntos
Neoplasias Colorretais/genética , Biologia Computacional/métodos , Instabilidade de Microssatélites , Adulto , Idoso , Idoso de 80 Anos ou mais , Algoritmos , Viés , Biomarcadores Tumorais/genética , Aprendizado Profundo , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Análise Serial de Tecidos
2.
PLoS One ; 16(7): e0253612, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34283864

RESUMO

The rise of machine learning (ML) has created an explosion in the potential strategies for using data to make scientific predictions. For physical scientists wishing to apply ML strategies to a particular domain, it can be difficult to assess in advance what strategy to adopt within a vast space of possibilities. Here we outline the results of an online community-powered effort to swarm search the space of ML strategies and develop algorithms for predicting atomic-pairwise nuclear magnetic resonance (NMR) properties in molecules. Using an open-source dataset, we worked with Kaggle to design and host a 3-month competition which received 47,800 ML model predictions from 2,700 teams in 84 countries. Within 3 weeks, the Kaggle community produced models with comparable accuracy to our best previously published 'in-house' efforts. A meta-ensemble model constructed as a linear combination of the top predictions has a prediction accuracy which exceeds that of any individual model, 7-19x better than our previous state-of-the-art. The results highlight the potential of transformer architectures for predicting quantum mechanical (QM) molecular properties.


Assuntos
Ciência do Cidadão/métodos , Ciência do Cidadão/tendências , Previsões/métodos , Algoritmos , Participação da Comunidade , Humanos , Aprendizado de Máquina/tendências , Imageamento por Ressonância Magnética/métodos , Espectroscopia de Ressonância Magnética/métodos , Modelos Estatísticos
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