[The analysis of data of large study of cholesterol level in population: on the issue of reference values of cholesterol].

The article deals with analysis of the results of large study of cholesterol level at the sampling of 52 075 patients. The median of values of common cholesterol exceeds 5.0 mmol/l in all groups of males older than 30-35 years and females older than 35-40 years. The percentage of patients with level of common cholesterol > or = 6.2 mmol/l consisted 40.15 in the age group of 40-69 years. The issue of presentation of the results of laboratory analysis of common cholesterol (reference values as compared with recommended values) is discussed.

[Action of a chalone-containing esophageal preparation on its epithelial cell proliferation]. / Izuchenie deistviia keilonsoderzhashchego preparata iz pishchevoda na proliferatsiiu kletok ego épiteliia.

The effect of esophageal chalone on epithelial cell reproduction in the esophagus was studied. Lyophilized aqueous extract from the esophagus was used. The following properties of the esophageal preparation have been revealed: it is water-soluble; it is present in the same tissue where it acts; it has tissue-specific effect (the preparation does not act on the mitotic and radioactive index in the epithelial crypts of the small intestine); its action is short-term and reversible; its effect on DNA division and synthesis in the esophageal epithelial cells is dose-dependent. Therefore, it is suggested that the esophageal preparation contains a chalone.

[Analysis of changes in mitotic activity and epidermal G2 chalone content in esophageal and tongue epithelia during the course of the day]. / Analiz izmenenii mitoticheskoi aktivnosti i soderzhaniia épidermal'nogo G2-keilona v épitelii pishchevoda i iazyka v techenie sutok.

The epidermal G2-chalone level and mitotic activity variations in the epithelium of the rabbit esophagus and tongue and correlation of these indices were studied during the day. Mitotic activity was determined by the mitotic index calculation. The epidermal G2-chalone localization was determined by the Coons indirect method with monospecific immune serum. Circadian rhythms of the mitotic activity with maximal level at morning hours and circadian rhythms of chalone synthesis were discovered in the epithelium of both the organs. The decrease of G2-chalone concentration was followed by maximal mitosis in the epithelium under consideration. Obviously, the increase of the mitotic activity was caused by the decrease of G2-chalone concentration. An assumption about circadian rhythms of mitosis formation by means of G2-chalones has been confirmed by the data obtained.