RESUMO
Propranolol and Dyazide (25 mg hydrochlorothiazide and 50 mg triamterene) were used singly to reduce the elevated blood pressure (systolic ranging from 170 to 271 mmHg and diastolic ranging from 100 to 141 mmHg) of 38 elderly hypertensive patients whose ages ranged from 69 to 91 years. Each compound was administered for a period of four weeks with a wash-out period of four weeks in between. The following parameters were assessed before and after each treatment period: cerebral blood flow (CBF), mental functions, cardiac output (CO), electrocardiogram, glomerular filtration rate (GFR) and serum biochemistry. Both systolic and diastolic blood pressure were significantly reduced following the administration of either compound. No significant change in CBF and CO could be observed after reducing the blood pressure whether Propranolol or Dyazide was used. The GFR was, however, significantly reduced and the plasma creatinine significantly increased following Dyazide but not Propranolol administration. As expected the administration of the latter compound was associated with a significant bradycardia. No significant change could be observed in the other parameters studied.
Assuntos
Anti-Hipertensivos/uso terapêutico , Pressão Sanguínea/efeitos dos fármacos , Hidroclorotiazida/uso terapêutico , Hipertensão/tratamento farmacológico , Propranolol/uso terapêutico , Triantereno/uso terapêutico , Idoso , Débito Cardíaco/efeitos dos fármacos , Circulação Cerebrovascular/efeitos dos fármacos , Cognição/efeitos dos fármacos , Combinação de Medicamentos/uso terapêutico , Eletrocardiografia , Feminino , Taxa de Filtração Glomerular/efeitos dos fármacos , Humanos , MasculinoRESUMO
A healthy young man developed unilateral claudication due to an isolated lesion of his external iliac artery, At operation, this was found to be obliterated by atherosclerotic change of long standing. No evidence of systemic disease was noted. A vascular reconstruction has allowed the patient to return to an active life style.
