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1.
Andrology ; 2024 Jul 10.
Artigo em Inglês | MEDLINE | ID: mdl-38988181

RESUMO

BACKGROUND: The epididymis is important for sperm maturation and without its proper development, male infertility will result. Biomechanical properties of tissues/organs play key roles during their morphogenesis, including the Wolffian duct. It is hypothesized that structural/bulk stiffness of the capsule and mesenchyme/extracellular matrix that surround the duct is a major biomechanical property that regulates Wolffian duct morphogenesis. These data will provide key information as to the mechanisms that regulate the development of this important organ. OBJECTIVES: To measure the structural/bulk stiffness in Pascals (force/area) of the capsule and the capsule and mesenchyme together that surrounds the Wolffian duct during the development. To examine the relative membrane tension of mesenchymal cells during the Wolffian duct development. Since Ptk7 was previously shown to regulate ECM integrity and Wolffian duct elongation and coiling, the hypothesis that Ptk7 regulates structural/bulk stiffness and mesenchymal cell membrane tension was tested. MATERIALS AND METHODS: Atomic force microscopy and a microsquisher compression apparatus were used to measure the structural stiffness. Biomechanical properties within the membranes of cells within the capsule and mesenchyme were examined using a membrane-tension fluorescent probe. RESULTS AND DISCUSSION: The structural stiffness (Pascals) of the capsule and underlying mesenchyme was relatively constant during development, with a significant increase in the capsule at the later stages. However, this increase may reflect the ECM and associated mesenchyme being close to the capsule because the coiling of the duct pushed or compressed them into that space. Keeping the capsule and mesenchyme/ECM at constant stiffness would ensure that the duct will continue to coil under similar biomechanical forces throughout the development. Cells within the capsule and mesenchyme at different Wolffian duct regions during the development had varying degrees of membrane lipid tension. It is hypothesized that the dynamic changes ensure the duct is kept at a constant stiffness regardless of any external forces. Loss of Ptk7 resulted in an increase in stiffness at E18.5, which was presumable due to the loss of integrity of the ECM within the mesenchyme. CONCLUSION: Biomechanical properties of the capsule and the mesenchyme/extracellular matrix that surround the Wolffian duct play an important role toward Wolffian duct morphogenesis, thereby allowing for the proper development of the epididymis and subsequent male fertility.

2.
Child Abuse Negl ; 111: 104771, 2021 01.
Artigo em Inglês | MEDLINE | ID: mdl-33160649

RESUMO

BACKGROUND: Adverse childhood experiences have been linked to poor health and adverse health behavior in adulthood. OBJECTIVE: This study aimed to estimate the prevalence of adverse childhood experiences among young Australian women (aged 20-25) and examine associations between adverse childhood experiences and adult health behaviors and physical and mental health. PARTICIPANTS AND SETTINGS: Data were from the 1989-95 cohort of the Australian Longitudinal Study on Women's Health, who completed the Adverse Childhood Experiences Scale at Survey 3 in 2015 (N = 8609). METHODS: Outcomes included: self-rated health, sexual health, psychological distress, depression, anxiety, suicide ideation, self-harm, substance abuse (drinking, smoking, illicit drugs), severe obesity, and exercise. Prevalence of childhood adversities were presented, with the association between childhood adversity and outcomes evaluated using log-binomial multivariable regressions (99% CI). RESULTS: While 59% of women reported experiencing at least one childhood adversity, 10% of participants reported adverse childhood experiences across four or more categories, indicating a significant burden of risk for young Australian women. Women reporting four or more categories had higher rates of poor physical health (adjPR = 1.79, 99% CI = 1.51-2.12), sexually transmitted infections (adjPR = 1.36, 99% CI = 1.11-1.67), and poor mental health (adjPR = 2.78, 99% CI = 2.34-3.32), and increased rates of severe obesity (adjPR = 2.14, 99% CI = 1.61-2.86) and smoking (adjPR = 2.23, 99% CI = 1.89-2.64). CONCLUSION: Using nationally representative data, this study shows adverse childhood experiences directly impact physical and mental health, and health behaviors in adulthood among young Australian women. The management of health and wellbeing in adulthood should look beyond the contemporaneous factors, incorporating a focus on how childhood adversity may negatively influence health behavior, health and wellbeing in later life.


Assuntos
Experiências Adversas da Infância , Comportamentos Relacionados com a Saúde , Adulto , Experiências Adversas da Infância/psicologia , Experiências Adversas da Infância/estatística & dados numéricos , Ansiedade/epidemiologia , Ansiedade/etiologia , Austrália/epidemiologia , Criança , Maus-Tratos Infantis/psicologia , Maus-Tratos Infantis/estatística & dados numéricos , Feminino , Humanos , Estudos Longitudinais , Masculino , Saúde Mental , Prevalência , Infecções Sexualmente Transmissíveis/epidemiologia , Infecções Sexualmente Transmissíveis/psicologia , Ideação Suicida , Inquéritos e Questionários , Saúde da Mulher/estatística & dados numéricos , Adulto Jovem
3.
Reprod Health ; 17(1): 155, 2020 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-33059695

RESUMO

BACKGROUND: The Australian population has an unmet need for contraception. However, evidence suggests contraceptive patterns of Aboriginal and Torres Strait Islander populations are unique. To tailor contraceptive services and meet the contraceptive needs of Aboriginal and Torres Strait Islander people, it is important to understand the contributing factors to contraceptive use and non-use. METHODS: This study aimed to systematically review and narratively synthesise the evidence exploring the factors influencing contraceptive use among Aboriginal and Torres Strait Islander people. A systematic literature search was initially run in September 2016 and was updated again in April and August of 2018. A qualitative narrative synthesis was conducted from 2018 to 2019. Factors influencing contraceptive use or non-use were explored using a Social Ecological Model. RESULTS: The review identified 17 studies meeting the inclusion criteria published between 1972 and 2018. Most of the included studies were qualitative (n = 11), with the remaining studies being mixed methods (n = 3) or quantitative (n = 3). The majority focused on either a localised geographic area or specific Aboriginal or Torres Strait Islander community (n = 11). One study specifically focused on factors influencing contraceptive use, albeit among postpartum women. The remaining studies discussed factors influencing contraceptive use within the context of risky behaviour, sexual transmitted infections, or contraceptive practices more generally. Factors unique to individual communities included community attitudes (e.g. importance of not being too young to have a baby), specific cultural norms (e.g. subincising the penis as part of transition to manhood), and access to culturally appropriate health services. Other factors, including contraceptive characteristics (e.g. discomfort of condoms) and reproductive coercion (e.g. partner wants a baby), were similar to those found in the broader population of Australia and internationally. Most studies were lacking in quality, warranting more methodologically sound studies in the future to further assess the factors contributing to contraceptive use or non-use among Aboriginal and Torres Strait Islander people. CONCLUSIONS: Identifying community specific facilitators, as well as understanding the more broadly applicable factors contributing to contraceptive use or non-use, is essential if wanting to offer appropriate contraceptive services within an Aboriginal or Torres Strait Islander community.


Assuntos
Comportamento Contraceptivo/etnologia , Anticoncepcionais/uso terapêutico , Serviços de Planejamento Familiar , Serviços de Saúde do Indígena , Havaiano Nativo ou Outro Ilhéu do Pacífico , Austrália/epidemiologia , Comportamento Contraceptivo/estatística & dados numéricos , Feminino , Humanos , Masculino
4.
BMC Med Res Methodol ; 19(1): 201, 2019 10 29.
Artigo em Inglês | MEDLINE | ID: mdl-31664906

RESUMO

BACKGROUND: Longitudinal research has demonstrated that experiences of abuse and adversity are not consistently reported over time; however, there is a paucity of available evidence regarding the consistency of reporting experiences of intimate partner violence (IPV) over time. This study aimed to investigate the consistency of self-reported IPV involving a partner or spouse. Differences in the health status of women according to consistency of IPV reporting was also investigated. METHODS: Survey data collected from the 1946-51 cohort of the Australian Longitudinal Study on Women's Health (ALSWH) between 1996 and 2016 were used (n = 13,715). Consistency of self-reported IPV was evaluated by responses to the question "Have you ever been in a violent relationship with a partner/spouse?" Demographic and health characteristics of consistent and inconsistent reporters of IPV were compared. Multinomial logistic regression was used to determine the strength of the association between demographic and health characteristics of the women and their consistency of longitudinal reporting of IPV. RESULTS: There were 10,966 women who answered IPV questions over six surveys, with 9610 women (87.6%) providing consistent responses. Inconsistent responses were provided by 1356 women (12.4%), of whom 258 (2.4%) reported IPV at all but one survey (Mainly IPV), 587 (5.3%) reported no IPV at all but one survey (Mainly no IPV), and 511 (4.7%) reported Mixed IPV responses over time. Women in the Mainly IPV group, and those in the Mixed IPV group were similar to those in the Consistent IPV group in demographic and health characteristics, whereas women in the Mainly no IPV group were similar to those in the Consistent never IPV group. CONCLUSIONS: IPV data collected at one time point may involve around 12% false negative or false positive responses. To increase reliability, IPV should be measured on more than one occasion, using different techniques and methods that account for intentional and unintentional over- and under-reporting.


Assuntos
Violência por Parceiro Íntimo/estatística & dados numéricos , Autorrelato/estatística & dados numéricos , Parceiros Sexuais , Maus-Tratos Conjugais/estatística & dados numéricos , Inquéritos e Questionários/estatística & dados numéricos , Adulto , Austrália , Estudos Transversais , Feminino , Humanos , Modelos Logísticos , Reprodutibilidade dos Testes , Fatores de Risco , Adulto Jovem
5.
J Med Internet Res ; 21(3): e11286, 2019 03 25.
Artigo em Inglês | MEDLINE | ID: mdl-30907739

RESUMO

BACKGROUND: With health research practices shifting toward rapid recruitment of samples through the use of online approaches, little is known about the impact of these recruitment methods on continued participation in cohort studies. OBJECTIVE: This study aimed to report on the retention of a cohort of young women who were recruited using an open recruitment strategy. METHODS: Women from the 1989-95 cohort of the Australian Longitudinal Study on Women's Health, recruited in 2012 and 2013 were followed up annually via Web-based surveys in 2014, 2015, and 2016. Prevalence ratios for survey response were calculated using log-binomial models with generalized estimating equations including demographic, health-related, and recruitment method characteristics examined as explanatory factors. RESULTS: Of the 17,012 women who completed the baseline survey (Survey 1) in 2012 to 2013, approximately two-thirds completed Survey 2 (2014), and just over half completed Surveys 3 (2015) and 4 (2016). Women demonstrated transient patterns of responding with 38.21% (6501/17,012) of women completing all 4 surveys. Although retention of young women was associated with older age, higher education, higher self-rated health status, and low engagement with adverse health behaviors, the method of recruitment was a key determinant of study participation in the multivariate model. Although women were more likely to be recruited into the cohort via social media (eg, Facebook), retention over time was higher for women recruited through traditional media and referral approaches. CONCLUSIONS: A balance must be obtained between achieving representativeness, achieving rapid cohort recruitment, and mitigating the pitfalls of attrition based on recruitment method in the new era of cohort studies, where traditional recruitment methods are no longer exclusively viable options.


Assuntos
Saúde da Mulher/tendências , Adolescente , Adulto , Estudos de Coortes , Feminino , História do Século XX , Humanos , Estudos Longitudinais , Mídias Sociais , Inquéritos e Questionários , Adulto Jovem
6.
J Child Sex Abus ; 28(5): 511-525, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-30285583

RESUMO

The current study aims to present the prevalence of adverse childhood experiences and examine the healthcare costs associated with primary, allied, and specialist healthcare services. The Australian Longitudinal Study on Women's Health is a general health survey of four nationally representative age cohorts. The current study uses 20 years of survey and administrative data (1996-2015) from the cohort born 1973-1978. Overall, 41% of women indicated at least one category of childhood adversity. The most commonly reported type of childhood adversity was having a household member with a mental illness (16%), with the most commonly reported ACES category being psychological abuse (17%). Women who had experienced adversity in childhood had higher healthcare costs than women who had not experienced adversity. The healthcare costs associated with experiences of adversity in childhood fully justify a comprehensive policy and practice review.


Assuntos
Experiências Adversas da Infância/estatística & dados numéricos , Maus-Tratos Infantis/estatística & dados numéricos , Família , Custos de Cuidados de Saúde/estatística & dados numéricos , Nível de Saúde , Violência por Parceiro Íntimo/estatística & dados numéricos , Aceitação pelo Paciente de Cuidados de Saúde/estatística & dados numéricos , Adolescente , Adulto , Austrália , Feminino , Humanos , Estudos Longitudinais , Adulto Jovem
7.
Aust N Z J Public Health ; 41(4): 394-398, 2017 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-28616882

RESUMO

OBJECTIVE: To identify the prevalence of bullying among women aged 18-23 in 2013, and to describe the demographic characteristics, health and risk factors of those who experienced bullying. METHODS: Cross-sectional analysis using data from the 1989-95 cohort of the Australian Longitudinal Study on Women's Health, a nationally representative cohort (n=16,801). RESULTS: More than one-quarter of women (28.4%) indicated they had never been bullied, 53.4% reported experiencing bullying in the past and 18.2% indicated that they were recently bullied. Women who had experienced bullying were more likely to have lower levels of education, less likely to be studying or employed, and had more difficulty managing on their income. Women who experienced bullying were more likely to use tobacco or illicit drugs, be overweight or obese and to be sedentary. Even after adjusting for these factors, women who had experienced bullying were at risk of poor physical health, psychological distress, suicidal thoughts and self-harm. CONCLUSIONS: This is the first nationally representative study to demonstrate the strong association between being a victim of bullying and health outcomes in a post-school-age population. Implications for public health: The findings highlight the need for interventions for women who have already experienced bullying and are past school age.


Assuntos
Bullying , Adolescente , Austrália , Bullying/estatística & dados numéricos , Estudos Transversais , Ajustamento Emocional , Feminino , Comportamentos Relacionados com a Saúde , Humanos , Prevalência , Adulto Jovem
8.
PLoS One ; 12(6): e0178138, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28582406

RESUMO

OBJECTIVES: To determine the impact of intimate partner violence on women's mental and physical health over a 16 year period and across three generations. PARTICIPANTS: Participants were from the Australian Longitudinal study on Women's Health, a broadly representative national sample of women comprised of three birth cohorts 1973-78, 1946-51 and 1921-26 who were randomly selected from the Australian Medicare (i.e. national health insurer) database in 1996 to participate in the longitudinal health and wellbeing survey. Since baseline, six waves of survey data have been collected. Women from each cohort who had returned all six surveys and had a baseline measure (Survey 1) for intimate partner violence were eligible for the current study. MAIN OUTCOME MEASURES: The main outcome of interest was women's physical and mental health, measured using the Medical Outcome Study Short-Form (SF-36). The experience of intimate partner violence was measured using the survey item 'Have you ever been in a violent relationship with a partner/spouse?' Sociodemographic information was also collected. RESULTS: For all cohorts, women who had lived with intimate partner violence were more likely to report poorer mental health, physical function and general health, and higher levels of bodily pain. Some generational differences existed. Younger women showed a reduction in health associated with the onset of intimate partner violence, which was not apparent for women in the older two groups. In addition, the physical health differences between women born 1921-26 who had and had not experienced intimate partner violence tapered off overtime, whereas these differences remained constant for women born 1973-78 and 1946-51. CONCLUSIONS: Despite generational differences, intimate partner violence adversely impacted on mental and physical health over the 16 year study period and across generations.


Assuntos
Violência por Parceiro Íntimo/psicologia , Saúde Mental/estatística & dados numéricos , Qualidade de Vida/psicologia , Parceiros Sexuais/psicologia , Saúde da Mulher/estatística & dados numéricos , Adulto , Idoso , Austrália , Feminino , Humanos , Estudos Longitudinais , Pessoa de Meia-Idade , Inquéritos e Questionários
9.
BMJ Open ; 6(5): e010630, 2016 05 17.
Artigo em Inglês | MEDLINE | ID: mdl-27188808

RESUMO

OBJECTIVE: Coping with arthritis-related stress has been extensively studied. However, limited evidence exists regarding coping with stress extraneous to the disease (life stress). This study explored life stress and coping in a subset of older women with osteoarthritis from a larger longitudinal study. SETTING: An Australian regional university. DESIGN: This qualitative study involved semistructured telephone interviews. Potential participants were mailed a letter of invitation/participant information statement by the Australian Longitudinal Study on Women's Health (ALSWH). Invitations were sent out in small batches (primarily 10). Interviews were conducted until data saturation was achieved using a systematic process (n=19). Digitally recorded interviews were transcribed verbatim and deidentified. Data were thematically analysed. PARTICIPANTS: Women who indicated being diagnosed or treated for arthritis in the previous 3 years in the fifth survey of the ALSWH (conducted in 2007) provided the sampling frame. Potential participants were randomly sampled by a blinded data manager using a random number generator. RESULTS: Coping with life stress involved both attitudinal coping processes developed early in life (ie, stoicism) and transient cognitive and support-based responses. Women also described a dualistic process involving a reduction in the ability to cope with ongoing stress over time, coupled with personal growth. CONCLUSIONS: This is the first study to examine how individuals cope with non-arthritis-related stress. The findings add to the current understanding of stress and coping, and have implications regarding the prevention of arthritis in women. Importantly, this study highlighted the potential detrimental impact of persistent coping patterns developed early in life. Public health campaigns aimed at stress mitigation and facilitation of adaptive coping mechanisms in childhood and adolescence may assist with arthritis prevention.


Assuntos
Osteoartrite/psicologia , Estresse Psicológico/psicologia , Saúde da Mulher , Adaptação Psicológica , Idoso , Austrália/epidemiologia , Feminino , Humanos , Estudos Longitudinais , Pessoa de Meia-Idade , Osteoartrite/epidemiologia , Filosofia , Pesquisa Qualitativa , Religião , Apoio Social , Estresse Psicológico/epidemiologia
10.
J Med Internet Res ; 17(5): e109, 2015 May 04.
Artigo em Inglês | MEDLINE | ID: mdl-25940876

RESUMO

BACKGROUND: In 2012, we set out to recruit a cohort of at least 10,000 women aged 18-23 from across Australia. With recent research demonstrating the inadequacy of traditional approaches to recruiting women in this age group, we elected to conduct open recruiting. OBJECTIVE: Our aim was to report on the overall success of open recruiting and to evaluate the relative success of a variety of recruitment methods in terms of numbers and demographics. METHODS: We used referrals, Facebook, formal advertising, and incentives in order to recruit the cohort. RESULTS: In all, 17,069 women were recruited for the longitudinal online survey, from 54,685 initiated surveys. Of these women, most (69.94%, n=11,799) who joined the longitudinal cohort were recruited via Facebook, 12.72% (n=2145) via the fashion promotion, 7.02% (n=1184) by referral, 4.9% (n=831) via other Web activities, and 5.4% (n=910) via traditional media. CONCLUSIONS: Facebook was by far the most successful strategy, enrolling a cohort of women with a similar profile to the population of Australian women in terms of age, area of residence, and relationship status. Women recruited via fashion promotion were the least representative. All strategies underrepresented less educated women-a finding that is consistent with more traditional means of recruiting. In conclusion, flexibility in recruitment design, embracing new and traditional media, adopting a dynamic responsive approach, and monitoring the results of recruiting in terms of sample composition and number recruited led to the successful establishment of a new cohort.


Assuntos
Inquéritos Epidemiológicos , Internet , Seleção de Pacientes , Saúde da Mulher , Adolescente , Austrália , Estudos de Coortes , Feminino , Humanos , Estudos Longitudinais , Encaminhamento e Consulta , Mídias Sociais , Inquéritos e Questionários , Adulto Jovem
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