Assuntos
Carcinoma de Células Escamosas/diagnóstico por imagem , Neoplasias Esofágicas/diagnóstico por imagem , Neoplasias Meníngeas/secundário , Carcinoma de Células Escamosas/secundário , Humanos , Masculino , Neoplasias Meníngeas/diagnóstico por imagem , Pessoa de Meia-Idade , Tomografia Computadorizada por Raios XAssuntos
Protocolos de Quimioterapia Combinada Antineoplásica/administração & dosagem , Carcinoma Hepatocelular/terapia , Neoplasias Hepáticas/terapia , Adulto , Terapia Combinada , Doxorrubicina/administração & dosagem , Humanos , Infusões Intra-Arteriais , Óleo Iodado/administração & dosagem , Masculino , Mitomicina , Mitomicinas/administração & dosagem , Dosagem Radioterapêutica , alfa-Fetoproteínas/análiseRESUMO
Cytotoxicity of peripheral blood lymphocytes against allogeneic target cells of bronchogenic carcinoma was examined by a microcytotoxicity test before, during, and after radiotherapy in primary lung cancer patients. Before the treatment, cytotoxicity was depressed only slightly in patients in stage III and strikingly in those in stage IV, as compared to the values in patients at earlier stages of lung cancer such as stages I AND II. Local irradiation scarcely affected cytotoxicity at stages II and III, but augmented remarkably at stage IV. The number of peripheral blood lymphocytes decreased profoundly during and after radiotherapy in all cases of stages II, III, and IV. Although radiotherapy exhibited various effects on the cytotoxic activity of lymphocytes and the number of peripheral blood lymphocytes, only the cytotoxic activity at the end of radiotherapy correlated well with the reduction in tumor size.
Assuntos
Carcinoma Broncogênico/imunologia , Citotoxicidade Imunológica/efeitos da radiação , Neoplasias Pulmonares/imunologia , Animais , Carcinoma Broncogênico/radioterapia , Linhagem Celular , Humanos , Neoplasias Pulmonares/radioterapia , Linfócitos/imunologia , Camundongos , Transplante de Neoplasias , Transplante HomólogoRESUMO
Cytotoxicity of lymphocytes against allogeneic target cells of a bronchogenic squamous cell carcinoma was examined by a microcytotoxicity test in lung cancer patients after the various kinds of anticancer treatment. Cytotoxicity in untreated cases at stages I, II, and III was higher than the range of controls, but cytotoxicity in those at stage IV decreased to the range of controls. Tumor resection augmented cytotoxicity in patients at stages II and III, when the assays were carried out 3 weeks after the operation. Local irradiation of tumors augmented cytotoxicity in patients at stages II, III, and IV, when the assays were carried out 1 week after the last irradiation. Immunotherapy with BCG cell-wall skeleton augmented cytotoxicity to a marked degree in patients at stages I, II, III, and IV, when the assays were carried out after 4 months of a continuous treatment. The microcytotoxicity test may be useful for estimating the reactivity of lymphocytes in lung cancer patients in various situations.
