Association Between the Size and 3D CT-Based Radiomic Features of Breast Cancer Hepatic Metastasis.

PURPOSE: To evaluate the effect of the anatomic size on 3D radiomic imaging features of the breast cancer hepatic metastases. MATERIALS AND METHODS: CT scans of 81 liver metastases from 54 patients with breast cancer were evaluated. Ten most common 3D radiomic features from the histogram and gray level co-occurrence matrix (GLCM) categories were calculated for the hepatic metastases (HM) and compared to normal liver (NL). The effect of size was evaluated by using linear mixed-effects regression models. The effect of size on different radiomic features was analyzed for both liver lesions and background liver. RESULTS: Three-dimensional radiomic features from GLCM demonstrate an important size dependence. The texture-feature size dependence was found to be different among feature categories and between the HM and NL, thus demonstrating a discriminatory power for the tissue type. Significant difference in the slope was found for GLCM homogeneity (NL slope = 0.004, slope difference 95% confidence interval [CI] 0.06-0.1, p <0.001), contrast (NL slope = 45, slope difference 95% CI 205-305, p <0.001), correlation (NL slope = 0.04, slope difference 95% CI 0.11-0.21, p <0.001), and dissimilarity (NL slope = 0.7, slope difference 95% CI 3.6-5.4, p <0.001). The GLCM energy (NL slope = 0.002, slope difference 95% CI -0.0005 to -0.0003, p <0.007), and entropy (NL slope = 1.49, slope difference 95% CI 0.07-0.52, p <0.009) exhibited size-dependence for both NL and HM, although demonstrating a difference in the slope between themselves. CONCLUSION: Radiomic features of breast cancer hepatic metastasis exhibited significant correlation with tumor size. This finding demonstrates the complex behavior of imaging features and the need to include feature-specific properties into radiomic models.

Dual-energy CT evaluation of gastrointestinal bleeding.

Gastrointestinal bleeding is a common cause for hospital admissions and is an important cause of morbidity and mortality. Although endoscopy is accepted as the standard initial diagnostic modality for the evaluation of gastrointestinal bleeding, multiphasic computed tomography (CT) imaging has become an alternative diagnostic tool. Dual-energy CT with post-processing techniques may have additional advantages over single-energy computed tomography in evaluation of gastrointestinal bleeding. In this article, we discuss the role of dual-energy CT in the evaluation of gastrointestinal bleeding with potential advantages over conventional CT and limitations.

Application of Iterative Metal Artifact Reduction Algorithm to CT Urography for Patients With Hip Prostheses.

OBJECTIVE. The purpose of this study is to retrospectively assess the impact of iterative metal artifact reduction (IMAR) with iterative reconstruction (IR) on the image quality and diagnostic performance of CT urography in the evaluation of patients with hip prostheses, compared with IR alone. MATERIALS AND METHODS. CT urography examinations that were reconstructed using IR with and without IMAR were analyzed for 57 patients (29 women and 28 men; mean age, 74 years [range, 22-94 years]) with hip prostheses (40 unilateral and 17 bilateral). For quantitative analysis, image noise within the bladder was measured. Two radiologists (radiologist 1 [RAD1] and radiologist 2 [RAD2]) qualitatively evaluated the images using both a 5-point scale to assess the degree of visualization of artifacts and a 6-point scale to determine diagnostic confidence in visualization of the bladder, ureters, prostate or uterus, pelvic calcifications, and genitourinary abnormalities involving the bladder, distal ureters, prostate, uterus, and ovaries. RESULTS. The combination of IMAR and an IR technique provided improvement in quantitative and qualitative measurements (p < 0.05). Forty-three genitourinary abnormalities were detected in 29 patients. Quantitative and qualitative comparisons of scans obtained with and without the use of IMAR, respectively, revealed image noise of 99.6 versus 173.3 HU and the following radiologist scores: for improvement of artifacts, 3.2 versus 1.6 (for RAD1) and 3.1 versus 1.6 (for RAD2); for visualization of the bladder, 3.6 versus 1.5 (RAD1) and 3.8 versus 1.6 (RAD2); visualization of the ureters, 3.8 versus 1.6 (RAD1) and 3.9 versus 1.7 (RAD2); visualization of the uterus, 4.3 versus 2.8 (RAD1) and 4.3 versus 2.6 (RAD2); visualization of the prostate, 4.5 versus 2.3 (RAD1) and 4.5 versus 2.2 (RAD2); diagnostic confidence for calcifications, 4.7 versus 3.5 (RAD1) and 4.7 versus 3.3 (RAD2); and diagnostic confidence for genitourinary abnormalities, 5.0 versus 3.2 (RAD1) and 4.8 versus 2.9 (RAD2), respectively. CONCLUSION. The addition of IMAR to IR led to statistically significant improvement in the retrospective diagnostic performance and image quality of CT urography for patients with hip prostheses, compared with IR alone.

Integration of fully automated computer-aided pulmonary nodule detection into CT pulmonary angiography studies in the emergency department: effect on workflow and diagnostic accuracy.

PURPOSE: To assess the feasibility of implementing fully automated computer-aided diagnosis (CAD) for detection of pulmonary nodules on CT pulmonary angiography (CTPA) studies in emergency setting. MATERIALS AND METHODS: CTPA of 48 emergency patients was retrospectively reviewed. Fully automated CAD nodule detection was performed at the scanner and results were automatically submitted to PACS. A third-year radiology resident (RAD1) and a cardiothoracic radiologist with 6 years' experience (RAD2) reviewed the scans independently to detect pulmonary nodules in two different sessions 8 weeks apart: session 1, CAD was reviewed first and then all images were reviewed; session 2, CAD was reviewed last after all images were reviewed. Time spent by RAD to evaluate image sets was measured for each case. Fisher's exact test and t test were used. RESULTS: There were 17 male and 31 female patients with mean ± SD age of 48.7 ± 16.4 years. Using CAD at the beginning was associated with lower average reading time for both readers. However, difference in reading time did not reach statistical significance for RAD1 (RAD1 94.6 s vs. 102.7 s, P > 0.05; RAD2 61.1 s vs. 76.5 s, P < 0.05). Using CAD at the end significantly increased rate of RAD1 and RAD2 nodule detection by 34% (2.52 vs. 2.12 nodule/scan, P < 0.05) and 27% (2.23 vs. 1.81 nodule/scan, P < 0.05), respectively. CONCLUSION: Routine utilization of CAD in emergency setting is feasible and can improve detection rate of pulmonary nodules significantly. Different methods of incorporating CAD in detecting pulmonary nodules can improve both the rate of detection and interpretation speed.

Comparison of Tin Filter-Based Spectral Shaping CT and Low-Dose Protocol for Detection of Urinary Calculi.

OBJECTIVE: The purpose of this study was to assess the performance of tin filter-based spectral shaping CT compared with routine low-dose CT for detection of urolithiasis. MATERIALS AND METHODS: Unenhanced third-generation dual-source CT scans of 129 consecutively registered patients were retrospectively reviewed: 43 patients underwent CT for detection of renal stones with tin filtration (Sn150 kV); 43 patients underwent a routine low-dose CT protocol at 100 kV; and 43 patients underwent a routine CT protocol with automated tube potential selection (110-120 kV). Image quality was evaluated subjectively and objectively. Volume CT dose index (CTDIvol) and size-specific dose estimate (SSDE) were recorded. To prospectively compare the performances of the spectral shaping protocol (Sn150 kV) with the standard (120 kV) and routine low-dose (100 kV) protocols, a phantom (sheep kidneys) containing stones were also scanned with each protocol and evaluated by two radiologists. RESULTS: CT with tin filtration resulted in 28% and 66% reduction in CTDIvol compared with CT performed with routine low-dose and standard-dose protocols (p < 0.05). Accordingly, it also led to 24% and 55% reduction in SSDE compared with the low-dose and standard protocols (p < 0.05). Subjective image quality and signal-to-noise ratio were similar between the tin filtration and the routine low-dose groups (p > 0.05). The objective image noise was similar in the three groups (p > 0.05). The phantom study showed no difference in detection of renal stones between the three tube potential settings. CONCLUSION: Using spectral shaping with tin filtration can substantially reduce radiation dose compared with routine standard- and low-dose abdominal CT for urinary stone disease.