RESUMO
OBJECTIVES: Our aim was to investigate the impact of subthalamic nucleus deep brain stimulation (STN-DBS) on the cardiovagal control of patients with advanced Parkinson's disease. MATERIALS AND METHODS: Twenty-four patients (mean age: 62.1 ± 9.4 years) were examined 3 days before and 6 months after DBS by a questionnaire, blood pressure monitoring and a battery of neurophysiological tests: time domain analysis of RR interval variation during normal and deep breathing (DB), Valsalva manoeuvre, and tilt test. By off-line, performed frequency domain analysis of heart rate variation, total power (TP), low frequency band (LF) band, high-frequency (HF) band, and their normalized units were estimated. The neurophysiological measurements were compared to those of 24 healthy controls. RESULTS: The values of time domain variables were pre- and postoperatively lower in patients than in controls. A significant reduction was found in LF band after the implantation. Orthostatic hypotension was present in 45.8% of the patients preoperatively and 12.5% postoperatively. There was no correlation between DBS-related changes of motor function and corresponding neurophysiological measurements, but patients with more than 60% motor improvement had higher time domain parameters' values than the others. CONCLUSIONS: STN-DBS offered no considerable impact on autonomic cardiovascular control.
