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1.
Am J Orthop (Belle Mead NJ) ; 40(3): 142-7, 2011 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-21720603

RESUMO

We propose comparing angiogenic effects of butyric acid (BA)-impregnated suture vs control suture on an aged tendon model. Twenty-four 3-year-old rabbits underwent bilateral Achilles tendon exposure. BA-impregnated orthopedic suture was sutured into one side, and a control orthopedic suture into the contralateral side similarly. The rabbits were sacrificed at 7, 30, and 45 days and the tendons harvested for gross, histologic, and biochemical study. Histologically, there was increased vascularity/cell migration at all time points in the BA-treated tendons; proteoglycan expression (ie, safranin O staining) increased at 30 and 45 days. DNA concentration was significantly (P = .05) higher in the BA-treated tendon group relative to the control group at 7 days but was unchanged at 30 and 45 days. Similarly, messenger RNA (mRNA) expression of vascular endothelial growth factor (VEGF) was significantly (P = .05) higher in the BA-treated tendon at 7 days. A trend (P = .12) for higher expression in the BA group also was found at 30 days.


Assuntos
Tendão do Calcâneo/efeitos dos fármacos , Ácido Butírico/farmacologia , Matriz Extracelular/efeitos dos fármacos , Antagonistas dos Receptores Histamínicos/farmacologia , Tendão do Calcâneo/irrigação sanguínea , Tendão do Calcâneo/metabolismo , Tendão do Calcâneo/patologia , Animais , Movimento Celular/efeitos dos fármacos , DNA/biossíntese , Matriz Extracelular/metabolismo , Matriz Extracelular/patologia , Expressão Gênica/efeitos dos fármacos , Neovascularização Fisiológica/efeitos dos fármacos , RNA Mensageiro/metabolismo , Coelhos , Fator A de Crescimento do Endotélio Vascular/genética , Fator A de Crescimento do Endotélio Vascular/metabolismo
2.
Orthopedics ; 32(5): 367, 2009 May.
Artigo em Inglês | MEDLINE | ID: mdl-19472949

RESUMO

Luxatio erecta, inferior dislocation of the glenohumeral joint, is a relatively rare type of glenohumeral dislocation, accounting for <0.5% of all shoulder dislocations. It has been well described in terms of presentation and conservative management. Arthroscopic findings after the more commonly found anteroinferior glenohumeral dislocation have also been described. However, we know of only 1 case report that details the arthroscopic findings and open surgical management in a patient who sustained a single episode of luxatio erecta. Additionally, we were unable to find any reports in the literature of the arthroscopic management of this type of dislocation. We present the arthroscopic findings and arthroscopic management of an 18-year-old male college football player who reported 7 episodes of left shoulder luxatio erecta. Arthroscopic evaluation revealed an extensive anterior capsulolabral injury as well as a superior labrum anteroposterior (SLAP) tear. Additionally, there were extensive articular cartilage changes of the anterosuperior glenoid, a posterior Hill-Sachs lesion, and an anterosuperior humeral head cartilage indentation. The anterior capsulolabral injury and the SLAP lesion were fixed arthroscopically with suture anchors. The remainder of the lesions were debrided. The patient was able to return to college-level football and reported no further episodes of instability, pain, or stiffness at 3-year follow-up.


Assuntos
Artroscopia/métodos , Futebol Americano/lesões , Luxação do Ombro/patologia , Luxação do Ombro/cirurgia , Lesões do Ombro , Articulação do Ombro/cirurgia , Adolescente , Humanos , Masculino , Recidiva , Articulação do Ombro/patologia , Resultado do Tratamento
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