RESUMO
A further case of chronic neutrophilic leukemia (CNL) is reported. On karyotype analysis of the bone marrow aspirate, all of the examined cells showed trisomy of chromosome 9 and partial deletion of the long arms of chromosome 20. This anomaly has never before been reported in CNL, and it could be directly associated to the disease.
Assuntos
Aberrações Cromossômicas , Leucemia Mieloide/genética , Idoso , Medula Óssea/ultraestrutura , Deleção Cromossômica , Cromossomos Humanos 19-20 , Cromossomos Humanos 6-12 e X , Humanos , Cariotipagem , Leucemia Mieloide/patologia , Masculino , Neutrófilos , TrissomiaRESUMO
279 male patients consecutively admitted to a medical ward were interviewed about their drinking habits using a CAGE-like questionnaire and were subdivided into teetotallers, normal-, borderline-, heavy-drinkers. The mean values of the following laboratory tests resulted significantly different in heavy drinkers compared with the others: mean cell volume, gamma-glutamyl-transpeptidase, serum urea (BUN), SGOT, SGPT, total bilirubin. No significant difference was found for triglycerides, uric acid, albumin and gamma-globulins. Sensitivity, specificity, predictive values of positive test and negative test, "goodness" were calculated for each of the 6 above-mentioned tests. Each of them had a linear correlation (inverse for BUN, direct for the others) between amount of alcohol intake and level of the test.
Assuntos
Alcoolismo/metabolismo , Alanina Transaminase/metabolismo , Aspartato Aminotransferases/metabolismo , Bilirrubina/sangue , Nitrogênio da Ureia Sanguínea , Índices de Eritrócitos , Feminino , Hospitalização , Humanos , Masculino , Estatística como Assunto , gama-Glutamiltransferase/metabolismoAssuntos
Cardiopatias/etiologia , Hipolipoproteinemias/complicações , Doença de Tangier/complicações , Arteriosclerose/etiologia , Fibrilação Atrial/etiologia , Cardiomegalia/etiologia , Insuficiência Cardíaca/etiologia , Sopros Cardíacos , Humanos , Masculino , Pessoa de Meia-Idade , Doença de Tangier/diagnósticoRESUMO
A 62-year-old man with clinical and biochemical findings consistent with homozygous Tangier disease is presented. Widespread atherosclerosis was present. Bile lipid analysis showed a low molar percentage of cholesterol with a low saturation index. The data suggest that high density lipoprotein cholesterol may act as a preferential precursor of biliary cholesterol. Coagulation and platelet studies indicated that the patient's platelets were hyper-responsive to aggregating agents and produced an increased amount of thromboxane B2. A platelet storage pool deficiency was also found.
