RESUMO
Chronic gastric ulcer is a rare disease in childhood. The article presents data on the epidemiology and etiology of the disease in children, describes the case of a chronic gastric ulcer complicated by penetration into the liver, perforation, development of abdominal sepsis, with a fatal outcome in a 7-year-old girl.
Assuntos
Úlcera Gástrica , Feminino , Humanos , Criança , Úlcera Gástrica/diagnóstico , Úlcera Gástrica/complicações , FígadoRESUMO
A description of two cases of cardiovascular syphilis is presented. The introduction discusses the relevance of visceral syphilis. The literary review is constructed in a chronological format and reflects the stages of studying the problem of cardiovascular syphilis. It emphasizes that cardiovascular syphilis is currently a rare pathology and internists are more likely to encounter it. Verification of the pathology of the cardiovascular system, including aortic aneurysm, during the early stages of syphilis (early latent) does not exclude the option of combined pathology. Early forms of syphilis in patients with diseases of the cardiovascular system should be considered a factor that complicates diagnosis. Such patients should be carefully examined to determine the cause of the disease. Rationale for the diagnosis of cardiovascular syphilis requires a comprehensive assessment of the results of clinical, laboratory and instrumental examination of the patient. A preliminary diagnosis of the specific etiology of an aortic aneurysm should be based on the following criteria: 1) relatively young age of patients with socially inappropriate sexual behavior; 2) sudden onset and rapid progression of the main signs of the disease. All patients with newly diagnosed aortic aneurysm at the outpatient stage should perform a serological examination. The diagnosis of cardiovascular syphilis, namely a syphilitic mesaortitis, can be established or confirmed by an autopsy.
Assuntos
Aneurisma Aórtico , Sistema Cardiovascular , Sífilis Cardiovascular , Sífilis , Autopsia , HumanosRESUMO
Liver diseases associated (acute fatty liver of pregnancy) and unassociated (liver hemangioma) with pregnancy and complications due to liver failure are serious conditions and can lead to maternal death. The paper describes two maternal deaths related to liver pathology.
Assuntos
Fígado Gorduroso , Hepatopatias , Complicações na Gravidez , Feminino , Humanos , Hepatopatias/complicações , Mortalidade Materna , GravidezRESUMO
This article reports the case of death of a puerperal woman resulting from amniotic fluid embolism. The diagnosis was established based on the results of the pathohistological study that revealed the presence of mucoproteides and epithelial scales in pulmonary blood vessels and capillaries.
Assuntos
Embolia Amniótica , Adulto , Embolia Amniótica/diagnóstico , Embolia Amniótica/etiologia , Embolia Amniótica/fisiopatologia , Embolia Amniótica/terapia , Feminino , Patologia Legal/métodos , Humanos , Morte Materna , Gravidez , Ressuscitação/métodosRESUMO
OBJECTIVE: To examine the specific features of cell differentiation and migration of neuroepithelial cells of the paraventricular region (PVR) in human fetuses with in utero encephalitis. MATERIALS AND METHODS: A morphometric technique was used to investigate the expression of vascular endothelial growth factor, tumor necrosis factor-alpha, and transforming growth factor-beta in the structures of the PVR of the thalamus in 47 fetuses with signs of in utero encephalitis and in 10 healthy fetuses at 26-27 weeks' gestation. RESULTS: In utero encephalitis was characterized by productive and productive-and-necrotic inflammation and in most cases it was a manifestation of generalized in utero infection. In in utero encephalitis, diminished PVR cellularity, a larger number of neurons and glial cells in the thalamic region, and that of glial fibrillary acidic protein-expressing cells, and enhanced cellular proliferative activity in the PVR implied the accelerated maturation of its cells. The decrease in the number of vessels in the PVR was caused by the lower cellular expression of vascular endothelial growth factor and transforming growth factor. CONCLUSION: In in utero encephalitis, there are significant changes in the processes of cell differentiation and migration in the fetal PVR, which was associated with a number of cytokines regulating an intercellular interaction.
Assuntos
Encéfalo/patologia , Diferenciação Celular , Encefalite/patologia , Complicações Infecciosas na Gravidez/patologia , Encéfalo/metabolismo , Encefalite/metabolismo , Feminino , Feto/metabolismo , Feto/patologia , Proteína Glial Fibrilar Ácida/metabolismo , Humanos , Neuroglia/metabolismo , Neurônios/metabolismo , Gravidez , Complicações Infecciosas na Gravidez/metabolismo , Fator de Necrose Tumoral alfa/metabolismo , Fator A de Crescimento do Endotélio Vascular/metabolismoRESUMO
The paper describes a clinical case of congenital Coxsackie B virus infection in a girl aged 1 month and 15 days of life who has undergone a detailed postmortem examination.
Assuntos
Infecções por Coxsackievirus/patologia , Enterovirus Humano B/patogenicidade , Infecções por Coxsackievirus/mortalidade , Infecções por Coxsackievirus/virologia , Feminino , Humanos , Recém-NascidoRESUMO
The paper describes a rare case of hereditary thesaurismosis, galactosemia, in a full-term neonate girl aged 12 days with morphologically verified fetal giant-cell cholestatic hepatitis with the development of ascitis and jaundice.
Assuntos
Colestase/patologia , Galactosemias/patologia , Hepatite/patologia , Doenças do Recém-Nascido/patologia , Icterícia Obstrutiva/patologia , Cirrose Hepática/patologia , Colestase/metabolismo , Colestase/terapia , Evolução Fatal , Feminino , Galactosemias/metabolismo , Galactosemias/terapia , Hepatite/metabolismo , Hepatite/terapia , Humanos , Recém-Nascido , Doenças do Recém-Nascido/metabolismo , Doenças do Recém-Nascido/terapia , Icterícia Obstrutiva/metabolismo , Icterícia Obstrutiva/terapia , Cirrose Hepática/metabolismo , Cirrose Hepática/terapiaRESUMO
The authors describe a case of the malignant retroperitoneal germ-cell tumor in a 20-year-old male, which appears as several types of tissues that are derivatives of three germinal layers with the presence in its composition of choriocarcinoma, metastases of which to the vital organs were a cause of death.
Assuntos
Coriocarcinoma/secundário , Neoplasias Retroperitoneais/patologia , Teratoma/secundário , Evolução Fatal , Humanos , Neoplasias Hepáticas/secundário , Neoplasias Pulmonares/secundário , Metástase Linfática , Masculino , Adulto JovemRESUMO
In CBA mice infected with C. albicans, phasic pattern of granulomatosis development was observed. In all groups, the number of granulomas in the liver was minimum on day 56 after infection. Treatment with free amphotericin B and its composition with dialdehyde dextran (CA) reduced the number of infiltrations and granulomas in the liver, the changes were more pronounced in animals receiving CA. A different pattern of cyclic fluctuations of cortisol content in the blood and adrenal glands and progesterone content in the adrenal gland was observed. By the end of observation (day 84), cortisol content in the blood and adrenals of mice treated with CA was considerably lower than in untreated mice and animals receiving amphotericin B.
Assuntos
Corticosteroides/sangue , Glândulas Suprarrenais/metabolismo , Anfotericina B/uso terapêutico , Anticoagulantes/uso terapêutico , Antifúngicos/uso terapêutico , Candidíase/tratamento farmacológico , Dextranos/uso terapêutico , Fígado/patologia , Corticosteroides/metabolismo , Glândulas Suprarrenais/efeitos dos fármacos , Anfotericina B/farmacologia , Animais , Anticoagulantes/farmacologia , Antifúngicos/farmacologia , Candidíase/sangue , Candidíase/metabolismo , Dextranos/farmacologia , Quimioterapia Combinada , Granuloma/patologia , Hidrocortisona/sangue , Fígado/efeitos dos fármacos , Fígado/metabolismo , Masculino , Camundongos , Camundongos Endogâmicos CBA , Progesterona/metabolismoRESUMO
The therapeutic efficacy of a composition of amphotericin B and dialdehyde dextran was much higher than that of amphotericin B in the therapy for systemic candidiasis. This conclusion was derived from the earlier and progressive decrease in the number and size of candidal granulomas in the kidneys. The composition of amphotericin B and dialdehyde dextran was more potent than amphotericin B in decreasing the nephrotoxic effect of C. albicans. The opposite strains of CBA and C57Bl/6 mice differed in morphological signs of granulomatosis in the kidneys, but not in the nephrotoxic effect of C. albicans metabolites.
Assuntos
Anfotericina B , Anticoagulantes , Antifúngicos , Candidíase/tratamento farmacológico , Dextranos , Nefropatias/tratamento farmacológico , Rim/efeitos dos fármacos , Anfotericina B/farmacologia , Anfotericina B/uso terapêutico , Animais , Anticoagulantes/farmacologia , Anticoagulantes/uso terapêutico , Antifúngicos/farmacologia , Antifúngicos/uso terapêutico , Dextranos/farmacologia , Dextranos/uso terapêutico , Nefropatias/microbiologia , Nefropatias/patologia , Masculino , Camundongos , Camundongos Endogâmicos C57BL , Camundongos Endogâmicos CBARESUMO
Lysosomotropic composition of dialdehyde dextran and amphotericin B had a greater therapeutic effect in mice with systemic candidiasis compared to free amphotericin B. This composition normalized glucocorticoid function of the adrenal glands and decreased the severity of liver destruction at late terms of granulomatous inflammation.
Assuntos
Anfotericina B/uso terapêutico , Candida albicans/efeitos dos fármacos , Candidíase/tratamento farmacológico , Anfotericina B/administração & dosagem , Anfotericina B/química , Animais , Antifúngicos/administração & dosagem , Antifúngicos/química , Antifúngicos/uso terapêutico , Candidíase/complicações , Candidíase/microbiologia , Dextranos/administração & dosagem , Dextranos/química , Dextranos/uso terapêutico , Modelos Animais de Doenças , Quimioterapia Combinada , Granuloma/etiologia , Granuloma/prevenção & controle , Hepatopatias/etiologia , Hepatopatias/prevenção & controle , Masculino , Camundongos , Camundongos Endogâmicos C57BLRESUMO
Intrauterine Candida albicans infection in mouse fetuses affected the type of granulomatous inflammation induced by BCG vaccine during the postnatal period. It manifested in increased formation of granulomas and variations in their cellular composition.
Assuntos
Candida albicans , Candidíase/imunologia , Granuloma/imunologia , Hepatopatias/imunologia , Fagócitos/imunologia , Tuberculose/imunologia , Animais , Vacina BCG/toxicidade , Candidíase/complicações , Modelos Animais de Doenças , Feminino , Granuloma/microbiologia , Hepatopatias/microbiologia , Camundongos , Monócitos/imunologia , Gravidez , Lesões Pré-Natais/imunologia , Lesões Pré-Natais/microbiologia , Tuberculose/complicações , Útero/microbiologiaRESUMO
In an experiment conducted using male CBA mice, cellular events during granulomatous Candida-induced inflammation were studied both in untreated animals and in animals treated with a new lysosomotropic composition, consisting of amphotericin B in intracellularly prolonged dextran immunomodulating matrix. To induce systemic Candida granulomatous inflammation, mice were given a single 0.2 ml intraperitoneal injection of Candida albicans culture (2.5 x 10(9) microbial bodies) dissolved in 0.9% isotonic saline. The findings obtained indicate greater therapeutic effect of amphotericin B and dextran dialdehyde composition as compared with a free (unconjugated) form of amphotericin B, that was manifested by the disappearance of granulomas and the capacity to prevent the development of spontaneous destructive processes in granulomas. Independent antimycotic effect of dextran dialdehyde was also demonstrated.