RESUMO
3 patients with secondary acute non-lymphoblastic leucosis have been observed. The cytogenetic analysis revealed pathologic karyotypes: 46, XY,+8, t(8;21), inv 16. Two patients have been found with typical markers of damaged chromosome of radiation origion. Insensibility of blastic cells to cytostatic therapy was typical for the patients.
Assuntos
Cromossomos Humanos Par 8/genética , Leucemia Mieloide Aguda/genética , Segunda Neoplasia Primária/genética , Trissomia , Adulto , Cromossomos Humanos Par 8/efeitos da radiação , Feminino , Humanos , Cariotipagem , Masculino , PrognósticoRESUMO
The article presents findings of the analysis on P-glycoprotein expression of leukemic cells in 52 acute myeloid leukemia (AML) patients. Of these, there were 20 persons exposed to ionizing radiation due to the Chernobyl accident and 32 patients with spontaneous disease. Leukemic cells in patients with radiation-associated AML compared to spontaneous cases more often were P-glycoprotein positive (12/20 vs 9/32, P<0,05). P-glycoprotein overexpression significantly correlated with resistant disease in patients with radiation-associated AML, but was not a prognostic variable for treatment outcome in terms of overall survival.
Assuntos
Membro 1 da Subfamília B de Cassetes de Ligação de ATP/biossíntese , Acidente Nuclear de Chernobyl , Leucemia Mieloide/metabolismo , Leucemia Induzida por Radiação/metabolismo , Doença Aguda , Adulto , Idoso , Idoso de 80 Anos ou mais , Células da Medula Óssea/metabolismo , Feminino , Citometria de Fluxo , Técnica Indireta de Fluorescência para Anticorpo , Humanos , Leucemia Mieloide/sangue , Leucemia Mieloide/mortalidade , Leucemia Induzida por Radiação/sangue , Leucemia Induzida por Radiação/mortalidade , Leucócitos/metabolismo , Masculino , Pessoa de Meia-Idade , Análise de Sobrevida , UcrâniaRESUMO
Patients with chronic myeloid leukemia (CML) have been shown to present with apparent metabolic abnormalities, such as enhanced endogenous intoxication against the background of deterioration of the functional condition of the liver and decline in immune reactivity of the organism; the erythrocytic membrane permeability changes considerably. The data secured are discussed from the standpoint of using them as prognostic criteria of the course of CML.
Assuntos
Leucemia Mielogênica Crônica BCR-ABL Positiva , Adulto , Doadores de Sangue , Permeabilidade da Membrana Celular/fisiologia , Estudos de Coortes , Membrana Eritrocítica/fisiologia , Feminino , Humanos , Leucemia Mielogênica Crônica BCR-ABL Positiva/sangue , Leucemia Mielogênica Crônica BCR-ABL Positiva/imunologia , Leucemia Mielogênica Crônica BCR-ABL Positiva/fisiopatologia , Fígado/imunologia , Fígado/fisiopatologia , Testes de Função Hepática , MasculinoRESUMO
A study was made into the effect of laferon on effectiveness of treatment of patients with chronic myeloid leukemia (CML). The authors have reached the conclusion that drug tolerance in the patients is fairly good. The number of negative reactions within a few days of the start of laferon therapy did not exceed the level reported from other countries. Small series and short-term follow-up does not allow judgement about effects of the drug on survival but one can say with certainty that the employment of laferon in the treatment programme for CML in different categories of risk permits achieving clinical and hematological compensation on more frequent occasions. The quality of the patients' life gets improved. Chemotherapy was found to lessen the risk for infectious and inflammatory complications.
Assuntos
Antineoplásicos/uso terapêutico , Interferon Tipo I/uso terapêutico , Leucemia Mielogênica Crônica BCR-ABL Positiva/tratamento farmacológico , Adolescente , Adulto , Antineoplásicos/efeitos adversos , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Feminino , Humanos , Interferon Tipo I/efeitos adversos , Leucemia Mielogênica Crônica BCR-ABL Positiva/sangue , Leucemia Mielogênica Crônica BCR-ABL Positiva/diagnóstico , Masculino , Pessoa de Meia-Idade , Proteínas Recombinantes , Indução de Remissão , Fatores de Risco , Fatores de TempoRESUMO
Molecular-biological approaches was applied for detection of Philadelphia chromosome in patients with chronic myeloid and acute lymphoblastic leukemias. It includes bcr-genomic probes and polymerase chain reaction with specific bcr/abl primers. The latter is more preferable for clinic use. Different diagnostic methods are compared and leukemias etiology problems are discussed.