Assuntos
Traumatismos do Tornozelo/etiologia , Neoplasias Ósseas/complicações , Osteoma Osteoide/complicações , Entorses e Distensões/etiologia , Luta Romana/lesões , Adolescente , Traumatismos do Tornozelo/diagnóstico , Neoplasias Ósseas/diagnóstico , Neoplasias Ósseas/patologia , Humanos , Masculino , Osteoma Osteoide/diagnóstico , Osteoma Osteoide/patologia , Cintilografia , Ossos do Tarso/diagnóstico por imagem , Tecnécio , Tomografia Computadorizada por Raios XRESUMO
A consecutive series of 47 patients with cervical radiculopathy secondary to spondylosis were treated with complete discectomy, root decompression accomplished by microscopic foraminotomy on the affected side(s), and iliac graft fusion at the involved interspace(s). Forty of the 47 patients were contacted with an average follow-up of 15 months. Eighty-three percent of the patients were judged as having good results. Fusion of the involved interspace(s) occurred in 87% of cases, although this did not appear to correlate with the clinical results.
Assuntos
Vértebras Cervicais , Disco Intervertebral/cirurgia , Síndromes de Compressão Nervosa/etiologia , Raízes Nervosas Espinhais , Osteofitose Vertebral/complicações , Adulto , Feminino , Seguimentos , Humanos , Masculino , Cuidados Paliativos , Complicações Pós-Operatórias , Estudos Retrospectivos , Fusão Vertebral , Infecção da Ferida Cirúrgica/terapiaRESUMO
Quantitative structure-pharmacokinetic relationships have been derived for a series of substituted 2-sulfapyridines. Pharmacokinetic parameters, such as elimination rate constant (ke), clearance (Cl), and protein-binding constant (Kassoc), have been determined in rats. The observed variation is statistically significant, explained by changes in the lipophilic (deltaRm), electronic (pKa), and steric effects (I, ES) of the substituents. The obtained correlations are discussed with respect to the previously derived correlations for the antibacterial activity of these compounds. A scale up of the results opens up the possibility of a rational synthesis of highly active sulfonamides with special pharmacokinetic properties because lipophilicity influences strongly the pharmacokinetic properties, whereas no influence on the degree of antibacterial effect is observed. Steric substituent influence is opposite on specific binding to bacterial enzymes and unspecific binding to serum proteins.
