Percolation as a single test to assess pollution potential of a waste.

A new test of percolation under pressure is proposed to estimate the pollution potential of wastes in various scenarios. Depending on the use foreseen for the material, samples can be analysed in a granular or monolithic state. The proposed trial keeps the physical structure of the samples and accelerates the phenomena by applying a pressure variation in order to obtain many important data, such as permeability and the environmental release of species. In this paper, some results of this percolation test are presented for hydraulic-binder-treated gravels and sands that include polluted treated sediments. The results are repeatable and a steady flow is reached for each kind of sample. Incorporation of the waste leads to a drop in the permeability of road materials even though their characterization shows that they are more porous. The capacity to resist aggressive ion penetration can then be estimated. The release kinetics of heavy metals are studied and the environmental release results are compared with data from a regulatory leaching test. Differences can be observed and the percolation test seems to be more sensitive for most of the heavy metals measured.

Cutaneous sarcoidosis occurring during anti-TNF-alpha treatment: report of two cases.

We report two cases of cutaneous granuloma induced by anti-TNF-alpha therapy: a 47-year-old man suffering from psoriatic arthritis treated with infliximab and a 56-year-old woman treated with adalimumab for polyarticular juvenile rheumatoid arthritis. The biospies confirmed the diagnosis of a 'sarcoidosis-like' reaction. No systemic involvement was observed. Such cases of noninfectious granulomatous diseases occurring during anti-TNF-alpha therapy are becoming increasingly frequent.

[Cutaneous T-cell lymphoma following renal transplantation]. / Lymphome T cutané après transplantation rénale.

INTRODUCTION: Post-transplant cutaneous lymphomas are the second skin cancer after cutaneous carcinoma and are usually of the B-cell type. Post-transplant cutaneous T-cell lymphomas are extremely rare. We described a case of a cutaneous T-cell lymphoma in a renal transplant recipient. CASE REPORT: A 52-year-old woman was hospitalized for an erythematous infiltrated eruption. Seven years earlier, she had undergone kidney transplantation. No palpable lymphadenopathy or hepatosplenomegaly was present. The patient's skin biopsy specimen was histologically suggestive of CD30- fungoid mycosis. The same clonal TCR-rearrangement was identified in the blood and in the skin. No EBV was detected within the cutaneous lesion on immunohistochemical analysis or by PCR in the blood. Chlorambucil (Chloraminophène) was associated with a topical treatment with chlormethine (Caryolysine) and corticosteroids while tacrolimus (Prograf) was reduced and stopped. There was no evidence of recurrence of the lymphoma after 12 months of follow-up. DISCUSSION: The particularity of our observation is the apparition, 7 years after transplantation, of a CD30-, EBV-fungoid mycosis with a blood and cutaneous clonal TCR-rearrangement. Despite this poor prognosis factor, the cutaneous lymphoma regressed after reduction of the immunosuppressive treatment reduction and institution of topical corticosteroids, chlormethine and chlorambucil.