RESUMO
A double-blind, randomized 4-week mianserin vs maprotiline trial was conducted in 48 depressed geriatric medical inpatients. The drug dosages were up to 90 mg of mianserin and up to 150 mg of maprotiline per day. Efficacy was measured by the Geriatric Depression Scale, the Hopkins Symptom Check List depression subscale and the Clinical Global Impression Scale. The overall dropout figure was 27% of the sample. Side effects were relatively similar in the two treatment groups and suggested a safety profile somewhat better than that of the first-generation antidepressants. Mianserin showed some advantages in efficacy over maprotiline, particularly by the 4th week of the trial, but the overall figures of treatment responders were rather small (Geriatric Depression Scale: mianserin 48%, maprotiline 30%). Clinical trials vs placebo are needed to clarify the role of antidepressant pharmacotherapy in depressed geriatric medical inpatients.
Assuntos
Antracenos/uso terapêutico , Transtorno Depressivo/tratamento farmacológico , Maprotilina/uso terapêutico , Mianserina/uso terapêutico , Transtornos Psicofisiológicos/tratamento farmacológico , Papel do Doente , Idoso , Idoso de 80 Anos ou mais , Transtorno Depressivo/psicologia , Método Duplo-Cego , Esquema de Medicação , Feminino , Humanos , Masculino , Maprotilina/efeitos adversos , Mianserina/efeitos adversos , Escalas de Graduação Psiquiátrica , Transtornos Psicofisiológicos/psicologia , Ensaios Clínicos Controlados Aleatórios como AssuntoRESUMO
The personality profiles, as evaluated with Cattell's 16 personality factors test (16 PF), were compared in 25 subjects with gastric ulcer, 25 with duodenal ulcer and 25 healthy controls. Subjects were matched for sex, age, education, geographical area of living and duration of illness (only for patients). The profiles of the gastric and duodenal ulcer patients were substantially similar and characterized by greater anxiety, dependence, introversion, low ego strength and greater adaptability as compared to the controls. Patients with gastric ulcer, however, seemed to be slightly more disturbed than those with duodenal ulcer.
Assuntos
Úlcera Duodenal/psicologia , Personalidade , Transtornos Psicofisiológicos/etiologia , Úlcera Gástrica/psicologia , Adulto , Idoso , Análise de Variância , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Testes de PersonalidadeRESUMO
Personality factors are thought to play a role in peptic ulcer disease. In this study the psychological profiles of chronic gastric ulcer (GU) patients (n = 28) were compared to matched controls (n = 28) using the Cattell Sixteen Personality Factor Questionnaire Form C. GU patients were characterized by traits of anxiety, dependence, introspection, trustfulness and adaptability. These findings are discussed in the light of the literature on personality and peptic ulcer disease.
