1.
Curr Drug Targets
; 10(8): 707-15, 2009 Aug.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19702519
RESUMO
Ketamine acts mainly as a N-methyl-D-aspartate receptor (NMDAr) antagonist. Originally developed as a general anesthetic, it is now seldom employed as such in richer countries due to the relatively high risk of psychotomimetic adverse effects. Recently, low-dose regimens in the range of 0.25-0.5 mg/kg as an initial bolus followed by 50-500 kappag/kg/h have been proposed as an adjuvant for postoperative analgesia and for the reduction of exogenous opioid-induced hyperalgesia. In this review, we examine the evidence for clinical usefulness of perioperative ketamine infusion and its role in the context of general and/or regional anesthesia.
Assuntos
Anestésicos Dissociativos/uso terapêutico , Antagonistas de Aminoácidos Excitatórios/uso terapêutico , Ketamina/uso terapêutico , Anestesia Geral , Anestesia Local , Anestésicos Dissociativos/administração & dosagem , Relação Dose-Resposta a Droga , Antagonistas de Aminoácidos Excitatórios/administração & dosagem , Humanos , Ketamina/administração & dosagem , Dor Pós-Operatória/fisiopatologia , Dor Pós-Operatória/prevenção & controle
2.
Minerva Anestesiol
; 58(10): 1127-8, 1992 Oct.
Artigo
em Italiano
| MEDLINE
| ID: mdl-1461416