Infarto agudo de miocardio asociado al consumo de sildenafil. Aportación de caso y revisión de la literatura / Acute myocardial infarction associated to the sildenafil consumption. A case report and review of the literature

La disfunción eréctil afecta aproximadamente a 30 millones de personas en los Estados Unidos. El Sildenafil fue el primer inhibidor de la 5-Fosfodiesterasa (5-PDE) aprobado por la FDA para la disfunción eréctil. Desde entonces su uso se ha incrementado notablemente. Este medicamento tiene varios efectos adversos generales como cefalea, enrojecimiento facial, congestión nasal, alteraciones visuales, dispepsia, diarrea, vértigo y rash; fenómenos cardiovasculares incluyen infarto de miocardio, taquicardia ventricular, angina y muerte. Las guías de manejo con respecto al uso del Sildenafil en pacientes con enfermedad coronaria, advierten sobre los riesgos cardiovasculares de la medicación. Se han reportado hasta el momento una cifra incierta de infartos de miocardio en pacientes tomando la medicación, hecho que ha obligado al productor a introducir una advertencia en la etiqueta. Nosotros reportamos un caso de IAM luego de la ingesta de 100 mg de sildenafil, sin relación sexual posterior y sin consumo de nitratos, pero con enfermedad arterioesclerótica difusa documentada por coronariografía

Erectile dysfunction affects more than 30 million men in The United States. Since the FDA approved the use of Sildenafil, prescription of this medication has been raising. Adverse events of Sildenafil includes: fatigue, dyspnea, and hypotension. Reported adverse cardiac events associated with the medication use include myocardial infarction, ventricular tachycardia, angina and death, raising concerns about the safety of this agent in patients with coronary artery disease. Published guidelines regarding the management of cardiac patients with erectile dysfunction suggest that Sildenafil may be hazardous in patients with ischemic heart disease. In patients using Sildenafil, myocardial infarctions have been reported to the Food and Drug Administration. Now, we report a patient with myocardial infarction after taking 100 mg of Sildenafil without sexual activity

Population of the Scattered Kuiper Belt.

We present the discovery of three new scattered Kuiper Belt objects (SKBOs) from a wide-field survey of the ecliptic. This continuing survey has to date covered 20.2 deg2 to a limiting red magnitude of 23.6. We combine the data from this new survey with an existing survey conducted at the University of Hawaii 2.2 m telescope to constrain the number and mass of the SKBOs. The SKBOs are characterized by large eccentricities, perihelia near 35 AU, and semimajor axes greater than 50 AU. Using a maximum likelihood model, we estimate the total number of SKBOs larger than 100 km in diameter to be N=&parl0;3.1+1.9-1.3&parr0;x104 (1 sigma errors) and the total mass of SKBOs to be M approximately 0.05 M plus sign in circle, demonstrating that the SKBOs are similar in number and mass to the Kuiper Belt inside 50 AU.