1.
Chem Commun (Camb)
; 52(98): 14141-14144, 2016 Dec 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27869276
RESUMO
Molecular tweezers for lysine and arginine select a few residues on a protein surface and by their unique complexation mode disrupt a critical protein-protein interaction. Detailed structural information was gained by NMR experiments, strongly supported by QM/MM calculations and further substantiated by ITC, fluorescence anisotropy, ELISA and bio-layer-interference studies.