RESUMO
BACKGROUND: The rarity of juvenile psammomatoid ossifying fibroma (JPOF) and lack of cytogenetic studies prompted us to report a novel SETD2 gene mutation in a benign odontogenic tumour. CASE PRESENTATION: A 21-year-old man presented with a hard, expanded mandibular cortex. Computed tomography revealed multilocular radiopacity in the mandible; this was reconstructed via segmental mandibulectomy using a vascularised iliac crest flap. Based on the clinical and histological findings, we diagnosed JPOF associated with an aneurysmal bone cyst. Microscopically, the solid area was characterised by many rounded or angular ossicles in a cellular fibrous stroma. The stromal cells were spindle-like or stellate. Next-generation sequencing detected a frame shift mutation of the SETD2 gene, while the copy number was normal. CONCLUSIONS: Our findings suggest further genetic studies should be performed to assess whether this mutation is related to tumour genesis. .
Assuntos
Biomarcadores Tumorais/genética , Cistos Ósseos Aneurismáticos/genética , Fibroma Ossificante/genética , Mutação da Fase de Leitura , Histona-Lisina N-Metiltransferase/genética , Neoplasias Mandibulares/genética , Tumores Odontogênicos/genética , Cistos Ósseos Aneurismáticos/diagnóstico por imagem , Cistos Ósseos Aneurismáticos/patologia , Cistos Ósseos Aneurismáticos/cirurgia , Análise Mutacional de DNA , Fibroma Ossificante/diagnóstico por imagem , Fibroma Ossificante/patologia , Fibroma Ossificante/cirurgia , Sequenciamento de Nucleotídeos em Larga Escala , Humanos , Masculino , Neoplasias Mandibulares/diagnóstico por imagem , Neoplasias Mandibulares/patologia , Neoplasias Mandibulares/cirurgia , Tumores Odontogênicos/diagnóstico por imagem , Tumores Odontogênicos/patologia , Tumores Odontogênicos/cirurgia , Adulto JovemRESUMO
Teeth exceeding the normal dental complement that have erupted into the nasal cavity are a rare pathological entity. This case report describes a female patient with recurrent complaints and fetid discharge from the left nasal cavity. The suspected clinical diagnosis of a supernumerary nasal tooth was confirmed by computed tomography. After endoscopic removal, the tooth was examined using X-ray microtomography and thin-section preparations; these findings are presented for the first time. A literature search identified 25 supernumerary nasal teeth in 23 patients.