[Assessment of the relationship of properties of chemical compounds and their toxicity to a unified hygienic standardization for chemicals].

The connection of thermodynamic properties and parameters of toxicity of chemical substances was determined. Obtained data are used for the evaluation of toxicity and hygienic rate setting of chemical compounds. The relationship between enthalpy and toxicity of chemical compounds has been established. Orthogonal planning of the experiment was carried out in the course of the investigations. Equation of unified hygienic rate setting in combined, complex, conjunct influence on the organism is presented. Prospects of determination of toxicity and methodology of unified hygienic rate setting in combined, complex, conjunct influence on the organism are presented

Enthalpy of chemical substances as a criterion of their hygienic standardization.

The data on toxicity estimation and hygienic regulation for chemical substances are presented. Toxicological studies were performed under conditions of acute experiment. We established the relationship between enthalpy and toxicity of chemical substances. A correlation between thermodynamic properties and toxicity parameters of chemical substances was found. The obtained data were used for evaluation of toxicity and hygienic standardization of chemical substances.