1.
J Org Chem
; 74(2): 910-3, 2009 Jan 16.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19072579
RESUMO
Described is a flexible synthesis of the C3-C14 domain of 7-deoxyokadaic acid that is amenable to facile structural diversification. Treatment of ynone 10 under acidic conditions led to net bis-conjugate addition of the latent diol to give the thermodynamically favored spiroketal 27, a versatile intermediate, en route to 7-deoxyokadaic acid and analogs.
