Tableting technology from the individual and new galenic alkaloid consisting preparations of the Phellodendron lavallei bark.

The aim of the research was to work out the technology and tablet composition from new galenic preparations consisting of alkaloids of the bark of Phellodendron lavallei and hydrochloride of berberin on the base of complex research. The bark of the Phellodendron lavallei introduced in Georgia contains alkaloids, from which 2% is berberine used for curing chronicle hepatitis, hepatic cholecystitis and bilestone disease. The structural-mechanical and technological character of tablets and their masses were defined by the known methodic. Friability was studied by defining the fluctuation and bending corner. Volume density was established by using vibration cylinder. Volume density of powders was studied by pyknometers. Porosity was calculated by the bearing of volume density of the masses. The size of pressing was established by defining the firmness of tablets. The granule composition was defined by analysis. On the basis of studying technological and physical-chemical character features of the substances of new galenic preparations and individual substances consisting of alkaloids got from the bark of Phellodendron lavallei, it is scientifically proved and practically offered optimal technological parameters of tablets forming process and recipes.

[Study of the process of diffusion of gentin tablets through the artificial lipid barrier].

Currently during medical treatment of the patients suffering with gastrointestinal system diseases, particular attention is being devoted to the medical remedies of plant origin, which allow its protracted use during these diseases without expressed negative influence on important functions and structures of organism. Study of the dependence of the diffusion rate of active substances presented here as a multi-component plant origin dosage form, from the dissolution profile of solid dosage form in gastrointestinal tract, is an actual biopharmaceutical problem, which gives an information about the completeness of release of the active substances from the dosage form and its bioavailability. Gentin tablets developed at the department of pharmaceutical technology of Tbilisi State Medical University, presents the phytopreparation recommended for the prevention and treatment of the diseases of gastro-intestinal system. In-vitro study of the diffusion kinetics of active compounds from gentin tablets were performed using membrane model "SARTORIUS" Sm 16750 (FRG), which allows study of the diffusion rate of medical substances in the conditions closely imitating gastro-intestinal tract. Obtained experimental data showed that gamma-pyronic compounds are better absorbed in intestines than in stomach, as the value of diffusion rate constant k(d) in intestinal juice (pH=6,8) is 9, 17 x 10(-3) cm/min, while k(d) in gastric juice (pH=1,2) is 1, 63 x 10(-3) cm/min, thus the diffusion process is much more intensive in intestinal media with pH=6,8.

[Technology of vitamins containing double layer suppositories].

At present ascorbic acid and cyanocobalamin are widely used in medical practice. Often they are administered simultaneously; chemically they are incompatible, as ascorbic acid (redox compound) inactivates cyanocobalamin. The combination of ascorbic acid and cyanocobalamin is the problem of pharmacy. To solve the problem double-layer suppositories containing two incompatible vitamins: ascorbic acid and cyanocobalamin were developed. Pharmaceutical bioavailability of ascorbic acid and cyanocobalamin has been studied using in-vitro methods to develop optimal base for suppositories. As a result of investigations optimal composition and technology of the double-layer suppositories containing ascorbic acid and cyanocobalamin which met requirements has been developed. Sequential release of active compounds and as a result - sequential pharmacologic action is achieved.

[Optimisation of the conditions of particle sizing of gentamicin sulfate].

One of the problems for the development of dry powder inhalation preparations is evaluation of particle size distribution of obtained micronized powders for the determination of theoretical aerodynamic diameter of the particles. The final aim of our study is the development of inhalation dry powder formulation of gentamicin sulfate, therefore it is necessary to determine theoretical aerodynamic diameter of micronized gentamicin sulfate particles. Micronized gentamicin sulfate powders are very cohesive and do not have satisfactory flow properties, the shape of the particles is close to spherical. The most suitable technique for this kind of powders is laser diffraction. On the basis of realized experiments the optimal conditions for the determination of particle size distribution of gentamicin powders were found. Results are in accordance with the data obtained by method-reference (Electron Microscopy).

[Dissolution study of the gentin tablets].

To establish individual dissolution test for the tablets gentin, which have a marked influence on the secretory function of the stomach (increase the free acidity of the gastric juice and stimulate enzymoproduction function of the stomach), and gastroprotective functioning, the conditions for the test realization were studied and specified, using apparatus "Rotating Basket" (Dissolution test, apparatus 1, p.1791, USP XXIII, 1995). For the quantification of the active ingredients in buffer solutions chromatospectrophotometric method was used. The same conditions were used for the accomplishment of the dissolution test using apparatus "Rotating Paddle" (Dissolution test, apparatus 2, p.1791, USP XXIII, 1995). Metrologic characteristics were compared for the evaluation of the reproducibility of the results. Obtained data showed better reproducibility of the results for the apparatus "Rotating Paddle" compare to the apparatus "Rotating Basket". Estimated conditions are useful for the routine control of the tablets "Gentin" in the case of manufacturing.