Assuntos
Altitude , Helioterapia , Dermatopatias/terapia , Clima , Contraindicações , Dermatologia/métodos , Complicações do Diabetes , Feminino , Humanos , Doenças do Sistema Nervoso/complicações , Gravidez , Estações do Ano , Dermatopatias/complicações , Dermatopatias/diagnóstico , Resultado do TratamentoRESUMO
Lichenoid eruptions appearing in two women receiving chrysotherapy (Solganal B oleosum R) a described. The morphological diagnosis, distribution of skin eruptions, histological and immunological features and monoclonal antibodies (Leu 4, Leu 2A and Leu 3A) against several cell surface markers were studied. Individual lesions were not distinguishable from idiopathic lichen planus, with some features typical for gold lichenoid eruptions: hyperpigmentation, psoriasiform eruptions, and hair loss. Histopathological and immunological examination of biopsy specimens with monoclonal antibodies generally confirms clinical impressions. The authors suggest similar pathogenetic mechanisms in the development of idiopathic lichen planus and of lichenoid eruptions after gold therapy.
Assuntos
Artrite Reumatoide/tratamento farmacológico , Aurotioglucose/efeitos adversos , Toxidermias/patologia , Líquen Plano/induzido quimicamente , Adulto , Idoso , Atrofia , Aurotioglucose/administração & dosagem , Feminino , Imunofluorescência , Humanos , Líquen Plano/patologia , Pele/patologiaRESUMO
A 58-year-old woman with progressive systemic sclerosis developed a butterfly erythematous eruption, hemorrhagic maculae, crusting, and erosions on the face 15 days following administration of D-penicillamine. This appeared to be a lupus erythematosus-like eruption due to an adverse drug reaction to D-penicillamine because of the rapid recovery from the general symptoms, the total involution of skin lesions with topical treatment only, the transient demonstration of autoantibodies and their fast negativation, negative ANA, and the histologic features of lupus erythematosus combined with marked exudative changes.
