1.
Org Biomol Chem
; 6(3): 447-50, 2008 Feb 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18219411
RESUMO
A novel class of (5-(pent-1-enyl)thiophen-2-yl)pyrazole antagonists was discovered, many of which exhibited potent CB1 activity and good CB1/2 selectivity, suggesting that along with a 1,3-transposition of the carbonyl of the pyrazole 3-carboxamide, bioisosteric replacement of the conventional pyrazole 5-aryl group with a thienyl ring substituted with an appropriate alkenyl moiety is viable.