PdSi focal-plane array detectors for short-wave infrared Raman spectroscopy of biological tissue: a feasibility study.

We have used a PdSi focal-plane array detector to measure short-wave infrared Raman spectra of pure compounds and human tissue. Raman bands of the pure compounds are clearly visible in the spectra, and a calcification feature at 960 cm(-1) is readily identifiable in the spectra of diseased human aorta. The performance characteristics of our detection device were good; dark noise contributed approximately 60 (electrons/s)/pixel, and the read noise was ~50 rms electrons/pixel. The primary noise in the spectra was due to fixed-pattern noise, which is the variation in measured signal across a detector when it is uniformly illuminated.