[The effect of quinidine monotherapy and combined therapy with digoxin on the central hemodynamics in patients with heart rhythm disorders]. / Vliianie monoterapii khinidinom i sochetannoi terapii s digoksinom na tsentral'nuiu gemodinamiku u bol'nykh s narusheniiami ritma serdtsa.

The study was undertaken to examine 84 patients mainly with coronary heart disease and various cardiac arrhythmias. Quinidine monotherapy was found to normalize heart rate depending on its baseline values: it reduced heart rate in tachycardias and increased it in bradycardia. In patients with severe myocardial damage, especially in hypertension, quinidine decreased cardiac index, whereas total peripheral resistance increased. With quinidine, systolic pressure, stroke and cardiac indices showed a more decrease, whereas diastolic pressure and total peripheral resistance displayed a more increase in the standing position. Supplement of digoxin corrected negative quinidine-induced hemodynamic changes and orthostatic failures.

[Dynamics of blood viscosity indices in patients with alcoholic myocardiodystrophy]. / Dinamika pokazatelei viazkosti krovi u bol'nykh alkogol'noi miokardiodistrofiei.

According to I. V. Strel'chuk's classification, 120 patients with alcoholic myocardiodystrophy induced by stage I-III chronic alcoholism were examined. The control group included 25 normal men. The rheological blood parameters (fluidity limit, apparent viscosity, red blood cell aggregation ratio, and hematocrit) were examined over time: before treatment, after its discontinuance, and one month after discharge from hospital. It was shown that blood viscosity increased with the disease gravity, whereas the results of the treatment correlated well with the initial patient's status. In stages I and II chronic alcoholism, the study parameters could return to normal, while in stage III, blood viscosity remained significantly higher than normal both towards the end of the treatment at hospital and on control examination one month after discharge. The control over blood rheology performed over time may be recommended as an additional method for assessing the disease gravity and efficacy of the treatment of alcohol-induced abnormalities.

[Pathogenesis of diabetic lesions of the myocardium]. / O patogeneze diabeticheskogo porazheniia miokarda.

On the basis of both literature data and their own observations, the authors suggest the identification of various forms of diabetic cardiopathy in relation to the pathogenetic mechanisms of the development of this complication. The microangiopathic form of diabetic cardiopathy develops as a result of cardiac diabetic microangiopathy. Vegetoneuropathic cardiopathy arises secondary to the impairment of the cardiac performance neural regulation associated with damage to the parasympathetic and/or sympathetic innervation of the heart secondary to diabetic vegetoneuropathy. Diabetic metabolic cardiopathy is induced by diabetic disorders in myocardial metabolism. A combined form of diabetic cardiopathy results from the combined lesion of the heart under the impact of the above specific mechanisms.