[Short-term prognosis of schizophrenia in developed and developing countries. WHO international study program]. / Kratkosrochnyi prognoz shizofrenii v razvitykh i razvivaiushchikh- sia stranakh. Mezhnarodnoie issledovanie po programme VOZ.

Two years of the catamnestic study of primary schizophrenia in a number of developed and underdeveloped countries using a common technique yielded a conclusion of likehood in short-term prognosis of the disease manifested in common types of its course. Nevertheless, a range of parameters reflecting clinical and social characteristics taken into account, the prognosis proved more benign in the developing countries. In discussion the possible explanation implying an increased rate of acute manifestations of schizophrenia in developing countries is rejected, for the benign prognosis of the disease takes shape in any type of the debute, regardless of its acuteness. The role of socio-cultural factors is assumed to be most pronounced in the above prognostic divergences.

[International study of schizophrenia based on a WHO program. Purposes and methods of the study]. / Mezhdunarodnoe issledovanie shizofrenii po programme VOZ. Zadachi i metody issledovaniia.

The authors report on a new transcultural investigation of schizophrenia in the framework of the WHO programme which involved 13 research centres from 10 countries and was aimed at identifying the prevalence, clinical manifestations and regularities of the course of schizophrenia in different countries. The authors discuss methodological requirements to the conduction of large-scale clinical and epidemiological cross-cultural studies and analyze the methodological experience of the current WHO programme.

[International study of schizophrenia based on a WHO program. Comparative characteristics of the data]. / Mezhdunarodnoe issledovanie shizofrenii po programme VOZ. Sravnitel'naia kharakteristika materiala.

The author compared cases of primary schizophrenia in ten countries. In analyzing the data the author used criteria of the ICD-9 and computerized diagnosis of the CATEGO. The differences revealed between the developed and developing countries concerned acute or chronic manifestations of schizophrenia, its clinical form and frequency of individual symptoms. The computer-aided diagnosis of cases failed to identify any discrete subgroup of schizophrenia, which seems to refute the theory of heterogeneity of this disease.

[International study of schizophrenia based on a WHO program. Incidence of schizophrenia]. / Mezhdunarodnoe issledovanie shizofrenii po programme VOZ. Zabolevaemost' shizofreniei.

The article presents data on the incidence of schizophrenia in one of the Moscow districts, which are compared with the findings obtained in 7 centres in different countries which used the same procedure of the investigation. Differences in the rate of morbidity between different countries were detected only when a broad diagnostic approach was employed, there being no such difference when narrow diagnostic criteria of schizophrenia were used, which indicates poor correlation between cultural factors and the development of schizophrenia with first-rank symptoms. The use of traditional clinical symptomatology has made it possible to reveal that the rate of different syndromes of manifest schizophrenia depends on sex and age.

[Electroencephalographic profile and dynamics of individual changes in the EEG of paranoid schizophrenics during treatment with aminazine (clinico-electroencephalographic correlation)]. / Elektroéntsefalograficheski i profil' i dinamika individual'nykh izmeneniia EEG u bol'nykh paranoidnoi schizofreniei pri lechenii aminazinom (kliniko-élektroéntsefalograficheskoe sopostavlenie).

The authors analyze the changes of the frequency and amplitude characteristics of EEGs in schizophrenic patients treated with aminazin. Under study there were changes characterizing the so-called EEG profile of aminazin, as well as changes reflecting individual reconstitution of the EEG in each patient. The changes related to the aminazin EEG profile, as well as the individual changes of the EEGs were found to be associated with the treatment efficacy ad the form of the schizophrenia course. The character of this association suggests that the EEG profile reflects the reactivity of the brain to the aminazin application, whereas the individual EEG changes are associated with the time course of the psychopathological manifestations in the patients treated.

[Effect of medical treatment on the antithymic activity of schizophrenic patients' serum]. / Vliianie lekarstvennoi terapii na antitimicheskuiu aktivnost' syvorotki krovi bol'nykh shizofreniei.

In 16 schizophrenic patients treated with aminazin changes of the serum antithymic activity (ATA) were studied in relation to the drug pharmacokinetics and peculiarities of the patients' psychic status. It was found that in a part of the patients the serum ATA level sharply fell immediately after the treatment onset; the psychopathological disturbances in these patients were reduced, and the patients developed remissions of a good quality. In another part of the patients the high serum ATA remained unchanged throughout the whole observation period. These patients were resistant to the drug therapy and had pronounced schizophrenic defects in their status.

[Clinical features of the Kandinsky-Clerambault syndrome in schizophrenic patients and prognosis]. / Klinicheskie osobennosti sindroma Kandinskogo-Klerambo u bol'nykh shizofreniei i voprosy prognoza.

The paper deals with the typology of conditions with a delusional variant of the Kandinsky-Clerambault syndrome in schizophrenia. At the basis of the differentiation there lie different types of delusional disturbances in the structure of which the syndrome is formed. Accordingly, 4 types of conditions have been distinguished: 1. developing in combination with interpretative systematized delusions; 2. interpretative non-systematized delusions; 3. acute fantastic paraphrenic delusions; 4. acute sensual delusions. Certain correlations were demonstrated between these types of delusional disturbances and the indices of the gravity of the schizophrenic process (the form of disease development, quality of negative disturbances, the depths of process intensification, following each of the types of conditions, index of working capacity, duration of attacks). The typology presented is discussed in the light of prognosis of the severity of the development of schizophrenias and its treatment.

[Place of clinical and pharmacokinetic parameters in prognosing the effectiveness of schizophrenic therapy]. / Mesto klinicheskikh i farmakokineticheskikh parametrov v prognoze éffektivnosti terapii shizofrenii.

A possibility has been studied of using certain clinical and pharmacokinetical parameters for the individual prediction of chlorpromazine efficacy in 25 schizophrenic patients with different degrees of progression. It was established that the most informative clinical parameter of a successful treatment prognosis is the disease course, polymorphic character of the structure in the prevalent syndrome with a generalization of disorders and an absence of delusional systematizations, a relatively low level of negative personality changes, alternating character of affective disorders in the initial stage of the disease and a certain development of the mental state after a single administration of a control dose of chlorpromazine. Assessment of the pharmacokinetic parameters was provided by the use of a mathematical modelling of pharmacokinetic processes. The most informative pharmacokinetic parameter was the period of half-life of the drug and the constant of the penetration rate from the intestine into blood.