RESUMO
SETTING: Heredity factors influence susceptibility to tuberculosis and other lung diseases. Recent immunogenetic studies have confirmed the genetic predisposition to lung diseases in different populations. Precise knowledge of genetic aspects of disease susceptibility is important for improvement of public health. OBJECTIVE: The aim of our research was to study the distribution of certain genetic markers in Tuvinian children suffering from tuberculosis and other lung diseases and to compare it with that in ethnically- and age-matched healthy donors. HLA-A, -B, -C and -DR antigens have been defined serologically by lymphocytotoxic assay, and variants of polymorphic protein loci Hp, Tf, Gc, ESD, ACP, PGM1, ADA, PGD have been defined by electrophoresis. RESULTS: It was demonstrated that in Tuvinian children with tuberculosis the frequencies of HLA-DR2 and HLA-DRw53 antigens are increased in comparison with healthy donors. In children with non-tuberculous chronic lung diseases with allergic components the frequency of HLA-A1, -B5 and -B8 antigens and of genetic variants Hp2-2 and ESD1-1 was elevated. CONCLUSION: HLA complex genetic factors influence susceptibility to tuberculosis and other lung diseases in Tuvinian children.
Assuntos
Marcadores Genéticos , Antígenos HLA/sangue , Tuberculose Pulmonar/genética , Adolescente , Estudos de Casos e Controles , Criança , Pré-Escolar , Doença Crônica , Suscetibilidade a Doenças , Antígenos HLA-DR/sangue , Antígeno HLA-DR2/sangue , Cadeias HLA-DRB4 , Antígenos de Histocompatibilidade Classe I/sangue , Humanos , Pneumopatias/genética , Federação Russa , Tuberculose Pulmonar/imunologiaRESUMO
Eighty three Tyvin patients with local pulmonary tuberculosis and 295 healthy donors of the same nationality were examined. They are resided in the central area of Tyva (in Kyzyl and its vicinities). In addition, 132 healthy Tyvin-Todjins were examined. Tuberculosis mortality was found to be associated with the antigen HLA-B15 in the Tyvins living in the central area of the Republic of Tyva (Kyzyl). The incidence of HLA antigens and polymorphic protein locus genotypes varies in different areas of the Republic of Tyva.
Assuntos
Proteínas Sanguíneas/genética , Pool Gênico , Antígenos HLA/genética , Tuberculose Pulmonar/genética , Doadores de Sangue , Distribuição de Qui-Quadrado , Eletroforese em Gel de Poliacrilamida/estatística & dados numéricos , Marcadores Genéticos , Genótipo , Humanos , Valores de Referência , Fatores de Risco , SibériaRESUMO
The genotype was studied according to the 8 polymorphic genetic systems (Gm, Hp, Tf, Gc, ESD, PGM, ACP and ADA) in 73 children suffering from tuberculosis and 251 healthy children of the Tuvinian nationality. Analysis of the data obtained showed that a positive association was found in the allotype G1m (2), phenotype G1m (+1, +2, +4) and the genetic variant ESD 2-2 with tuberculosis in subjects of the Tuvinian nationality, and a negative association with the genotype ESD 1-1. It has been suggested that these genetic markers play a definite role in susceptibility to tuberculosis.
