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J Subst Abuse Treat ; 26(4): 285-94, 2004 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-15182893

RESUMO

Naltrexone may be more effective for treating opioid (heroin) dependence in Russia than in the U.S. because patients are mostly young and living with their parents, who can control medication compliance. In this pilot study we randomized 52 consenting patients who completed detoxification in St. Petersburg to a double blind, 6-month course of biweekly drug counseling and naltrexone, or counseling and placebo naltrexone. Significant differences in retention and relapse favoring naltrexone were seen beginning at 1 month and continuing throughout the study. At the end of 6 months, 12 of the 27 naltrexone patients (44.4%) remained in treatment and had not relapsed as compared to 4 of 25 placebo patients (16%; p<0.05). Since heroin dependence is the main way HIV is being spread in Russia, naltrexone is likely to improve treatment outcome and help reduce the spread of HIV if it can be made more widely available.


Assuntos
Dependência de Heroína/reabilitação , Naltrexona/uso terapêutico , Antagonistas de Entorpecentes/uso terapêutico , Adulto , Análise de Variância , Terapia Combinada , Método Duplo-Cego , Feminino , Humanos , Masculino , Projetos Piloto , Psicoterapia , Federação Russa
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