The role of neural tuning in quantity perception.

Perception of quantities, such as numerosity, timing, and size, is essential for behavior and cognition. Accumulating evidence demonstrates neurons processing quantities are tuned, that is, have a preferred quantity amount, not only for numerosity, but also other quantity dimensions and sensory modalities. We argue that quantity-tuned neurons are fundamental to understanding quantity perception. We illustrate how the properties of quantity-tuned neurons can underlie a range of perceptual phenomena. Furthermore, quantity-tuned neurons are organized in distinct but overlapping topographic maps. We suggest that this overlap in tuning provides the neural basis for perceptual interactions between different quantities, without the need for a common neural representational code.

Adaptation to visual numerosity changes neural numerosity selectivity.

Perceiving numerosity, i.e. the set size of a group of items, is an evolutionarily preserved ability found in humans and animals. A useful method to infer the neural underpinnings of a given perceptual property is sensory adaptation. Like other primary perceptual attributes, numerosity is susceptible to adaptation. Recently, we have shown numerosity-selective neural populations with a topographic organization in the human brain. Here, we investigated whether numerosity adaptation can affect the numerosity selectivity of these populations using ultra-high field (7 Tesla) functional magnetic resonance imaging (fMRI). Participants viewed stimuli of changing numerosity (1 to 7 dots), which allowed the mapping of numerosity selectivity. We interleaved a low or high numerosity adapter stimulus with these mapping stimuli, repeatedly presenting 1 or 20 dots respectively to adapt the numerosity-selective neural populations. We analyzed the responses using custom-build population receptive field neural models of numerosity encoding and compared estimated numerosity preferences between adaptation conditions. We replicated our previous studies where we found several topographic maps of numerosity-selective responses. We found that overall, numerosity adaptation altered the preferred numerosities within the numerosity maps, resulting in predominantly attractive biases towards the numerosity of the adapter. The differential biases could be explained by the difference between the unadapted preferred numerosity and the numerosity of the adapter, with attractive biases being observed with higher difference. The results could link perceptual numerosity adaptation effects to changes in neural numerosity selectivity.

Distinct temporal mechanisms modulate numerosity perception.

Our ability to process numerical and temporal information is an evolutionary skill thought to originate from a common magnitude system. In line with a common magnitude system, we have previously shown that adaptation to duration alters numerosity perception. Here, we investigate two hypotheses on how duration influences numerosity perception. A channel-based hypothesis predicts that numerosity perception is influenced by adaptation of onset/offset duration channels which also encode numerosity or wire together with numerosity channels (duration/numerosity channels). Hence, the onset/offset duration of the adapter is driving the effect regardless of the total duration of adaptation. A strength-of-adaptation hypothesis predicts that the effect of duration on numerosity perception is driven by the adaptation of numerosity channels only, with the total duration of adaptation driving the effect regardless of the onset/offset duration of the adapter. We performed two experiments where we manipulated the onset/offset duration of the adapter, the adapter's total presentation time, and the total duration of the adaptation trial. The first experiment tested the effect of adaptation to duration on numerosity discrimination, whereas the second experiment tested the effect of adaptation to numerosity and duration on numerosity discrimination. We found that the effect of adaptation to duration on numerosity perception is primarily driven by adapting duration/numerosity channels, supporting the channel-based hypothesis. In contrast, the effect of adaptation to numerosity on numerosity perception appears to be driven by the total duration of the adaptation trial, supporting the strength-of-adaptation hypothesis. Thus, we show that adaptation of at least two temporal mechanisms influences numerosity perception.

Running in the Family? Structural Brain Abnormalities and IQ in Offspring, Siblings, Parents, and Co-twins of Patients with Schizophrenia.

Structural brain abnormalities and cognitive deficits have been reported in patients with schizophrenia and to a lesser extent in their first-degree relatives (FDRs). Here we investigated whether brain abnormalities in nonpsychotic relatives differ per type of FDR and how these abnormalities are related to intelligent quotient (IQ). Nine hundred eighty individuals from 5 schizophrenia family cohorts (330 FDRs, 432 controls, 218 patients) were included. Effect sizes were calculated to compare brain measures of FDRs and patients with controls, and between each type of FDR. Analyses were repeated with a correction for IQ, having a nonpsychotic diagnosis, and intracranial volume (ICV). FDRs had significantly smaller ICV, surface area, total brain, cortical gray matter, cerebral white matter, cerebellar gray and white matter, thalamus, putamen, amygdala, and accumbens volumes as compared with controls (ds < -0.19, q < 0.05 corrected). Offspring showed the largest effect sizes relative to the other FDRs; however, none of the effects in the different relative types survived correction for multiple comparisons. After IQ correction, all effects disappeared in the FDRs after correction for multiple comparisons. The findings in FDRs were not explained by having a nonpsychotic disorder and were only partly explained by ICV. FDRs show brain abnormalities that are strongly covarying with IQ. On the basis of consistent evidence of genetic overlap between schizophrenia, IQ, and brain measures, we suggest that the brain abnormalities in FDRs are at least partly explained by genes predisposing to both schizophrenia risk and IQ.

Adaptation reveals unbalanced interaction between numerosity and time.

Processing quantities such as the number of objects in a set, size, spatial arrangement and time is an essential means of structuring the external world and preparing for action. The theory of magnitude suggests that number and time, among other continuous magnitudes, are linked by a common cortical metric, and their specialization develops from a single magnitude system. In order to investigate potentially shared neural mechanisms underlying numerosity and time processing, we used visual adaptation, a method which can reveal the existence of a dedicated processing system. We reasoned that cross-adaptation between numerosity and duration would concur with the existence of a common processing mechanism, whereas the absence of cross-adaptation would provide evidence against it. We conducted four experiments using a rapid adaptation protocol where participants adapted to either visual numerosity or visual duration and subsequently performed a numerosity or duration discrimination task. We found that adapting to a low numerosity altered the estimation of the reference numerosity by an average of 5 dots, compared to adapting to a high numerosity. Similarly, adapting to a short duration altered the estimation of the reference duration by an average of 43 msec, compared to adapting to a long duration. In the cross-dimensional adaptation conditions, duration adaptation altered numerosity estimation by an average of 1 dot, whereas there was not sufficient evidence to either support or reject the effect of numerosity adaptation on duration judgments. These results highlight that there are partially overlapping neural mechanisms which are dedicated for processing both numerosity and time.

Transient Prepubertal Mifepristone Treatment Normalizes Deficits in Contextual Memory and Neuronal Activity of Adult Male Rats Exposed to Maternal Deprivation.

Early life adversity is a well-known risk factor for behavioral dysfunction later in life, including the formation of contextual memory; it is also (transiently) accompanied by hyperactivity of the stress system. We tested whether mifepristone (MIF) treatment, which among other things blocks glucocorticoid receptors (GRs), during the prepubertal period [postnatal days (PND)26-PND28] normalizes memory deficits in adult male rats exposed to 24-h maternal deprivation (MD) at PND3. MD reduced body weight gain and increased basal corticosterone (CORT) levels during the PND26, but not in adulthood. In adulthood, contextual memory formation of MD compared to noMD (i.e., control) male rats was significantly impaired. This impairment was fully prevented by MIF treatment at PND26-PND28, whereas MIF by itself did not affect behavior. A second behavioral test, a rodent version of the Iowa Gambling Task (rIGT), revealed that flexible spatial learning rather than reward-based aspects of performance was impaired by MD; the deficit was prevented by MIF. Neuronal activity as tested by c-Fos staining in the latter task revealed changes in the right hippocampal-dorsomedial striatal pathway, but not in prefrontal areas involved in reward learning. Follow-up electrophysiological recordings measuring spontaneous glutamate transmission showed reduced frequency of miniature postsynaptic excitatory currents in adult CA1 dorsal hippocampal and enhanced frequency in dorsomedial striatal neurons from MD versus noMD rats, which was not seen in MIF-treated rats. We conclude that transient prepubertal MIF treatment normalizes hippocampus-striatal-dependent contextual memory/spatial learning deficits in male rats exposed to early life adversity, possibly by normalizing glutamatergic transmission.