RESUMO
Cervical preparations from 89 women were studied for antigen associated with squamous-cell cervical cancer (SCCC) by the indirect immunofluorescence method. The antigen was revealed specifically in 77.8% of samples of SCCC (stages Ib, II and III) in 64.3% of samples of cancer (in situ and stage Ia) in 55.5% of samples of displasia (stages II and III) and in 17.2% of samples from tumours of other organs. In samples of 9 healthy women the antigen was not revealed. Thus, the detection of antigen associated with SCCC may be useful in elaboration of adjuvant diagnostic and prognostic tests.
Assuntos
Antígenos de Neoplasias/análise , Carcinoma de Células Escamosas/diagnóstico , Neoplasias do Colo do Útero/diagnóstico , Carcinoma de Células Escamosas/imunologia , Diagnóstico Diferencial , Feminino , Imunofluorescência , Humanos , Displasia do Colo do Útero/diagnóstico , Neoplasias do Colo do Útero/imunologiaRESUMO
An analysis of a more than 40-year experience of management of stage Ib, T1bN0M0 cervical cancer (611 cases) followed the development of combined treatment of the disease: Until 1970-ies, irradiation plus surgery was preferred. During the seventies no correlation between effectiveness and sequence of these component procedures was established. According to data on 33 surgical cases, extended extirpation of the uterus may be recommended in patients with stage Ib cervical cancer less than 5 mm deep and free from such adverse prognostic factors as concomitant pregnancy, poor cell differentiation and blood and lymph vascular microembolism by tumor.
Assuntos
Neoplasias do Colo do Útero/terapia , Colo do Útero/patologia , Terapia Combinada , Feminino , Humanos , Histerectomia , Gravidez , Complicações Neoplásicas na Gravidez/patologia , Complicações Neoplásicas na Gravidez/cirurgia , Complicações Neoplásicas na Gravidez/terapia , Prognóstico , Neoplasias do Colo do Útero/patologia , Neoplasias do Colo do Útero/cirurgiaAssuntos
Carcinoma de Células Escamosas/etiologia , Infecções Tumorais por Vírus/complicações , Neoplasias do Colo do Útero/etiologia , Carcinoma de Células Escamosas/patologia , DNA de Neoplasias/genética , DNA Viral/genética , Feminino , Humanos , Hibridização de Ácido Nucleico , Papillomaviridae/genética , Papillomaviridae/patogenicidade , Papillomaviridae/ultraestrutura , Fatores de Risco , Infecções Tumorais por Vírus/patologia , Neoplasias do Colo do Útero/patologiaRESUMO
The tumour-associated antigen was identified with the aid of antisera obtained from rabbits immunized with 3 M KCl extract of pool human cervical carcinoma cells. The antigen was found in 92.5% specimens of human cervical squamous cell carcinoma, in 4.7% specimens of other localization of the tumours. The antigen was absent from sets of normal human tissues. The tumour-associated antigen was not identical with CEA, alpha-fetoprotein, SP1, EPA and lactoferrin and it was localized in cytoplasm of cervical carcinoma cells.
Assuntos
Antígenos de Neoplasias/análise , Carcinoma de Células Escamosas/diagnóstico , Neoplasias do Colo do Útero/diagnóstico , Animais , Anticorpos Antineoplásicos/análise , Antígenos de Neoplasias/imunologia , Antígenos de Neoplasias/isolamento & purificação , Colo do Útero/imunologia , Feminino , Imunofluorescência , Humanos , Soros Imunes/isolamento & purificação , Imunização , Imunodifusão , Especificidade de Órgãos , CoelhosRESUMO
Organ-saving surgery was used in 134 patients with early cervical cancer (high amputation with a lancet-98 and cryotherapy-36 cases). The efficiency of the procedure was verified by morphological examination of samples obtained from the operation site at certain periods after primary treatment. The results of surgical treatment and hormonotherapy of early endometrial cancer (66 and 17 cases, respectively) are presented. Sparing methods may be used for treatment of early cancer of the uterus. Due to their application, menstrual, sexual and reproductive functions are preserved.
