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2.
Neuroimage ; 17(1): 385-92, 2002 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-12482091

RESUMO

The purpose of our study is to clarify, using functional MRI, brain regions activated during the fist-edge-palm task (FEP) compared to relatively simple hand motor tasks using either the right or the left hand in right-handed normal volunteers. The FEP was introduced to detect a disorder of voluntary movement, and it is believed to be closely related to contralateral frontal lobe damage. However, this assumption still remains controversial. Ten subjects participated in this study. Hand motor tasks were as follows: (1) the FEP, in which the subjects were requested to place their hand in three different positions sequentially: a fist resting horizontally, a palm resting vertically, and a palm resting horizontally; (2) a fist-palm task (FP), in which the subjects were asked to clench and unclench their fist alternately; and (3) a control task requiring the subjects to knock lightly with their clenched fist. The contralateral sensomotor and premotor areas were activated in the FP with the right hand and the contralateral sensorimotor, premotor, and supplementary motor areas (SMA) were activated in the FP with the left hand. In the FEP with either hand, bilateral premotor and left parietal areas and ipsilateral cerebellum were also activated as well as contralateral sensorimotor area and SMA. Our results suggest that successful performance of the FEP requires the participation of more brain areas than FP, which may explain why some patients without frontal lobe damage failed to perform the FEP.


Assuntos
Encéfalo/fisiologia , Mãos/fisiologia , Imageamento por Ressonância Magnética/métodos , Transtornos dos Movimentos/diagnóstico , Desempenho Psicomotor/fisiologia , Adulto , Mapeamento Encefálico , Lateralidade Funcional/fisiologia , Humanos , Interpretação de Imagem Assistida por Computador , Masculino
3.
Neuroimage ; 14(5): 1168-74, 2001 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-11697948

RESUMO

Sensorimotor association is an essential aspect of behavior. The dorsal part of the premotor cortex (PMd) is known to have an important role in sensorimotor association. Although it is suggested that the partially segregated groups of neurons are involved in sensorimotor association in different sensory modalities, it is not yet clear whether these groups occupy the PMd to the same or different extent. Therefore, we performed a functional magnetic resonance imaging study to compare activated regions in the PMd during simple reaction-time tasks with visual and auditory cues. Eight normal volunteers performed two simple reaction time tasks with a conventional on-off design; one is with a visual cue and the other is with an auditory cue. In both tasks, two regions in the left primary motor area (M1) (4a and 4p) and the bilateral PMd were activated. The two activated regions in the left M1 occupied the same areas in both the visual and the auditory tasks. However, in the PMd, the activated regions were situate medially during the visual task and laterally during the auditory task, along the precentral sulci. There was no overlap of significantly activated regions between two tasks, and areas specifically activated during the visual task were observed in the middle of the precentral sulci, bilaterally. The results suggest that the distribution of PMd subregions involved in sensorimotor association differ when the sensory cues are in different modalities.


Assuntos
Nível de Alerta/fisiologia , Percepção Auditiva/fisiologia , Imageamento por Ressonância Magnética , Córtex Motor/fisiologia , Tempo de Reação/fisiologia , Córtex Somatossensorial/fisiologia , Percepção Visual/fisiologia , Adulto , Atenção/fisiologia , Mapeamento Encefálico , Dominância Cerebral/fisiologia , Feminino , Humanos , Masculino
4.
Tohoku J Exp Med ; 193(1): 57-65, 2001 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-11321051

RESUMO

Two cases of isolated retrograde amnesia were reported. Both showed the same clinical pattern in development and resolution of amnesia despite of different etiologies. Sudden insult to the brain (trauma in Case 1 and viral encephalitis in Case 2) caused concurrent antero- and retrograde amnesia. Fortunately both recovered from the anterograde amnesia completely. However, both were left with a period of postictal amnesia of a few months and retrograde amnesia of up to 14 months' duration. The analysis of their pattern of temporal evolution and dissolution of amnesia support the hypothesis that recently acquired episodic information requires a certain amount of constant activation for a certain period of time in order to be organized into a durable memory. The nature of this activation as well as its origin remains to be solved.


Assuntos
Amnésia Retrógrada/psicologia , Acidentes de Trânsito , Adulto , Amnésia Retrógrada/etiologia , Amnésia Retrógrada/patologia , Confusão/psicologia , Eletroencefalografia , Feminino , Humanos , Imageamento por Ressonância Magnética , Testes Neuropsicológicos , Tomografia Computadorizada de Emissão de Fóton Único , Aprendizagem Verbal
5.
Brain Res Cogn Brain Res ; 11(1): 13-21, 2001 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-11240107

RESUMO

We used functional magnetic resonance imaging (fMRI) to investigate neural correlates of processes concerning store and manipulation in verbal working memory. We prepared a revised lag 1 digit span, digit span and a simple number detection task. Specific activities in association with manipulating process were identified in the right middle (BA 9/46) and left precentral gyrus (BA 6). Activated areas specific to maintaining process were detected in the right middle (right BA 11/10) and medial (BA 6) frontal gyri, the right inferior parietal lobule (BA 40), and the left middle (BA 9) and inferior frontal gyri (BA 44). The process-nonspecific activated areas common to two processes were identified in the right inferior frontal gyrus (BA 47) and the left superior parietal lobule (BA 7). Using the signal percent change of each subject, we calculated the correlation coefficients among each activated area. The results of this analysis showed that two processes of verbal working memory were clearly discriminated. The two essential processes of manipulation and maintenance in working memory seem to activate process-specific and overlapping (process-nonspecific) areas, but the patterns of combination were definitely different.


Assuntos
Encéfalo/fisiologia , Imageamento por Ressonância Magnética , Memória de Curto Prazo/fisiologia , Comportamento Verbal/fisiologia , Adulto , Comportamento/fisiologia , Encéfalo/anatomia & histologia , Mapeamento Encefálico , Feminino , Lobo Frontal/anatomia & histologia , Lobo Frontal/fisiologia , Humanos , Masculino , Pessoa de Meia-Idade , Lobo Parietal/anatomia & histologia , Lobo Parietal/fisiologia , Estimulação Luminosa/métodos
6.
J Clin Exp Neuropsychol ; 22(3): 391-8, 2000 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-10855046

RESUMO

We examined the effect of age on working memory with a reading span task (RST) together with other verbal span tasks. Sixty-two participants were divided into three subgroups (young, middle-aged, and elderly). The RST performances were significantly different among all the subgroups. To elucidate which component of the working memory system is affected by age, we performed an analysis of covariance with the scores of simple and complex verbal span tasks as covariates. From the results, we conclude that the difference of the RST performance between the middle-aged and elderly groups reflects a decline in the capacity of the phonological loop, and the difference between the young and middle-aged groups reflects malfunctioning of the central executive system.


Assuntos
Envelhecimento/psicologia , Cognição/fisiologia , Memória/fisiologia , Leitura , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Modelos Psicológicos , Testes Neuropsicológicos , Valores de Referência
7.
Neuroreport ; 11(2): 323-8, 2000 Feb 07.
Artigo em Inglês | MEDLINE | ID: mdl-10674479

RESUMO

We used PET to identify brain regions associated with retention of verbal materials in long-term memory. During a PET scan, subjects repeated many sets of words one after another. In a retention condition, they were simultaneously required to retain 10 key words that were irrelevant to the repetition task. Significant increases in regional cerebral blood flow during the retention condition were found in bilateral parahippocampal regions, the left prefrontal and parietal association cortices, the supplementary motor area, the neostriatum and the cerebellum. We clearly demonstrated that retention of verbal materials was accompanied by neural activities in the medial temporal lobes. We also showed that, in the early phase, retention of words in long-term memory recruited left cortical areas surrounding those relevant to verbal short-term memory.


Assuntos
Mapeamento Encefálico , Encéfalo/diagnóstico por imagem , Encéfalo/fisiologia , Retenção Psicológica/fisiologia , Estimulação Acústica , Adulto , Encéfalo/metabolismo , Cerebelo/irrigação sanguínea , Córtex Cerebral/irrigação sanguínea , Circulação Cerebrovascular/fisiologia , Hipocampo/irrigação sanguínea , Humanos , Masculino , Reforço Verbal , Análise e Desempenho de Tarefas , Tomografia Computadorizada de Emissão
8.
J Neurophysiol ; 83(2): 1079-87, 2000 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-10669519

RESUMO

The purpose of this study was to determine, by using functional magnetic resonance imaging, the areas of the brain activated during a memory-timed finger movement task and compare these with those activated during a visually cued movement task. Because it is likely that subjects engage in subvocalization associated with chronometric counting to achieve accurate timing during memory-timed movements, the authors sought to determine the areas of the brain activated during a silent articulation task in which the subjects were instructed to reproduce the same timing as for the memory-timed movement task without any lip movements or vocalization. The memory-timed finger movement task induced activation of the anterior lobe of the cerebellum (lobules IV and V) bilaterally, the contralateral primary motor area, the supplementary motor area (SMA), the premotor area (PMA), the prefrontal cortex, and the posterior parietal cortex bilaterally, compared with the resting condition. The same areas in the SMA and left prefrontal cortex were activated during the silent articulation task compared with the resting condition. The anterior lobe of the cerebellum on both sides was also activated during the silent articulation task compared with the resting condition, but these activations did not reach statistical significance (P < 0.05 corrected). In addition, the anterior cerebellum on both sides showed significant activation during the memory-timed movement task when compared with the visually cued finger movement task. The visually cued finger movement task specifically activated the ipsilateral PMA and the intraparietal cortex bilaterally. The results indicate that the anterior lobe of the cerebellum of both sides, the SMA, and the left prefrontal cortex were probably involved in the generation of accurate timing, functioning as a clock within the CNS, and that the dorsal visual pathway may be involved in the generation of visually cued movements.


Assuntos
Cerebelo/fisiologia , Dedos/fisiologia , Imageamento por Ressonância Magnética , Memória/fisiologia , Movimento/fisiologia , Adulto , Humanos , Masculino , Córtex Pré-Frontal/fisiologia , Desempenho Psicomotor/fisiologia , Percepção do Tempo/fisiologia
9.
No To Shinkei ; 51(11): 985-90, 1999 Nov.
Artigo em Japonês | MEDLINE | ID: mdl-10586417

RESUMO

In an early-life, a memory disturbance affects the learning and school record directly. Furthermore, it may cause the problem of maltreatment or adaptation difficulty for school life. We report a child amnesia caused by a traumatic brain injury when she was 9 years old. We examined her episodic and semantic memory. We developed 3-steps tasks of recognition and recall for the post-accident episodic memory. First, the examiner presented the patient with four words orally including a label of her episode, and asked her to choose one that she felt familiar with (the recognition of the episodic label). Second, if the word she selected was correct, she was required to recall the episode related to the word (the recall of the episode). Third, if she could not recall the episode herself correctly, she was required to choose a correct sentence about the episode (the recognition of the episode). She could not recall episodes correctly, but produced confabulation instead. She showed, however, good recognition of each episode. Furthermore, we performed recognition tests of time, person, and place about the same post-accident episodes, which were poor especially for time. In semantic memory tasks, we examined about kanji characters (ideogram) learned from the first grade to the sixth grade and mathematical knowledge learned from the second grade to the sixth grade at elementary school ("What centimeters is equal to one meter?" or "Tell me the formula of the size of a circle." etc). We found that she showed a retrograde impairment for about one year. For both episodic and semantic memory, she showed an anterograde impairment. Because of the anterograde amnesia she could not acquire new facts, and also showed para-amnesia or confabulation. In a child with brain damage, neuropsychological assessment is important in predicting effect of rehabilitation and recovery of school performance.


Assuntos
Lesões Encefálicas/psicologia , Memória , Adolescente , Lesões Encefálicas/complicações , Feminino , Humanos , Imageamento por Ressonância Magnética , Transtornos da Memória/etiologia , Semântica
10.
Percept Mot Skills ; 88(2): 457-65, 1999 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-10483639

RESUMO

The present study examined the relationship between unilateral brain damage and the effect of nonverbal perceptual priming using a picture-fragment completion task. Subjects consisted of 11 left brain-damaged patients, 8 right brain-damaged patients, and 10 healthy normal controls. The mean score of normal controls was significantly higher than those of left and right brain-damaged patients. Although there were significant effects of priming in all the groups, a significant difference in amplitude of priming effects was found only between right brain-damaged patients and normal controls. The correlation between amount of fragmentation at which there was identification and priming effect was not significant. We conclude that the right hemisphere is more involved in perceptual priming of form than is the left hemisphere, and form-dependent processing in the perceptual priming task has an asymmetrical distribution in the right and left hemispheres.


Assuntos
Encefalopatias/diagnóstico , Percepção de Forma , Lateralidade Funcional/fisiologia , Memória , Fechamento Perceptivo , Adulto , Idoso , Encefalopatias/psicologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade
11.
No To Shinkei ; 51(2): 137-42, 1999 Feb.
Artigo em Japonês | MEDLINE | ID: mdl-10198902

RESUMO

In clinical practice, we often use the Luria's fist edge-palm test (FEP) to detect frontal lobe dysfunction. However, we have sometimes encountered patients with failure in this test following posterior lesions. The aim of our study is to evaluate the sensitivity of this test to frontal lobe damage and to clarify the relationship between the FEP performance and other neuropsychological findings. Forty brain-damaged patients (mean age: 61.7 years) were studied. Thirty-four patients were right-handed and 6 non right-handed. Their lesions were confirmed by CT or MRI scan. Following six tests were performed; 1) imitation of single hand posture, 2) imitation of a sequence of two hand postures (fist-edge), 3) imitation of a sequence of three and postures (FEP), 4) copying a cube, 5) serial drawing, and 6) verbal and non-verbal short-term memory span. Imitation of hand postures were performed with non-paralytic hand. Twenty-four patients, i.e., 60% of the patients tested, failed to perform the FEP sequence. The failure was significantly correlated with the presence of constructional disability, perseveration and short-term memory impairment. There was significant relationship between the failure the FEP and frontal lobe damage. However, we found five patients without frontal lesion who failed in performing the FEP. We conclude that we should be careful in associating the failure in the FEP with frontal lobe damage, although this test is sensitive to brain dysfunction.


Assuntos
Transtornos Cerebrovasculares/diagnóstico , Bateria Neuropsicológica de Luria-Nebraska , Adulto , Idoso , Infarto Cerebral/diagnóstico , Transtornos Cerebrovasculares/patologia , Feminino , Lobo Frontal/irrigação sanguínea , Humanos , Masculino , Memória , Pessoa de Meia-Idade , Movimento
12.
Neurology ; 52(5): 1096-9, 1999 Mar 23.
Artigo em Inglês | MEDLINE | ID: mdl-10102442

RESUMO

A patient with a selective deficit in retrieving proper names after left temporal lobectomy is reported. He showed proper name anomia in conversation, in response to photographs, and in verbal descriptions, despite being able to provide semantic information about the people he was unable to name. This report provides evidence that the rostral part of the left temporal lobe plays a crucial role in processing proper names without involvement of other verbal functions.


Assuntos
Anomia/psicologia , Lobo Temporal/cirurgia , Anomia/patologia , Epilepsia Parcial Complexa/cirurgia , Humanos , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Testes Neuropsicológicos , Lobo Temporal/patologia
13.
Neurosci Lett ; 253(2): 127-30, 1998 Sep 04.
Artigo em Inglês | MEDLINE | ID: mdl-9774166

RESUMO

Prospective memory is a memory feature in humans which involves activities for remembering to do something in the future. The present study provides functional neuroanatomy of prospective memory for the first time. We used positron emission tomography (PET) and found several localized brain activations in relation to a prospective memory task required to retain and remember a planned action while performing an ongoing routine activity. Activations were identified in the right dorsolateral and ventrolateral prefrontal cortices, the left frontal pole and anterior cingulate gyrus, the left parahippocampal gyrus, and midline medial frontal lobe. We attributed these activations to several cognitive processes involved in prospective memory, such as holding an intention toward future behavior, checking target items within presented stimuli, and dividing attention between the planned action and the routine activity.


Assuntos
Memória/fisiologia , Córtex Pré-Frontal/fisiologia , Tomografia Computadorizada de Emissão , Adulto , Atenção/fisiologia , Mapeamento Encefálico , Lobo Frontal/anatomia & histologia , Lobo Frontal/fisiologia , Giro do Cíngulo/anatomia & histologia , Giro do Cíngulo/fisiologia , Humanos , Masculino , Atividade Motora/fisiologia , Córtex Pré-Frontal/anatomia & histologia , Análise e Desempenho de Tarefas
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